RESUMO
Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating nanocarriers. This paper reviews the various conventionally used and current used carriage system to deliver drugs. Due to numerous drawbacks of conventional DDSs, nanocarriers have gained immense interest. Nanocarriers like polymeric nanoparticles, mesoporous nanoparticles, nanomaterials, carbon nanotubes, dendrimers, liposomes, metallic nanoparticles, nanomedicine, and engineered nanomaterials are used as carriage systems for targeted delivery at specific sites of affected areas in the body. Nanomedicine has rapidly grown to treat certain diseases like brain cancer, lung cancer, breast cancer, cardiovascular diseases, and many others. These nanomedicines can improve drug bioavailability and drug absorption time, reduce release time, eliminate drug aggregation, and enhance drug solubility in the blood. Nanomedicine has introduced a new era for drug carriage by refining the therapeutic directories of the energetic pharmaceutical elements engineered within nanoparticles. In this context, the vital information on engineered nanoparticles was reviewed and conferred towards the role in drug carriage systems to treat many ailments. All these nanocarriers were tested in vitro and in vivo. In the coming years, nanomedicines can improve human health more effectively by adding more advanced techniques into the drug delivery system.
RESUMO
OBJECTIVE: To determine the management of professionalism issues by foreign returned doctors who are practicing clinicians after returning from abroad. METHODS: The qualitative study was conducted in tertiary care hospitals of Khyber Pakhtunkhwa province from January to August 2016. Purposive sampling technique was used to include foreign returned doctors who shared how they managed professionalism matters in context of contrasting cultures at home and abroad. The participants were interviewed in-depth and the audio records were transcribed verbatim. The data analysis generated codes that were consolidated under categories and then themes. RESULTS: Interviews with ten foreign returned doctors led to 20 codes that resulted in eight categories out of which four main themes were developed namely; Foreign Cultural influence that observed how their stay abroad have influenced their practice methods. Experience, showed how personal experiences of the interviewees helped forge their practice rules in Pakistan. Social Contract theme included the ways in which foreign returned doctors understood and accepted the concept of social contract in Pakistan as compared to west and how they adapted accordingly. Wise Man Approach included the help sought and received by foreign returned doctors from their senior colleagues in managing and adjusting to societal norms regarding professional behaviours in Pakistan. CONCLUSION: There are multiple dissimilarities between the socio cultural aspects, practices and knowledge of foreign returned and local medical practitioners. There exists a gap in knowledge with regards to their clinical practice between foreign returned and local doctors. To authors knowledge foreign returned doctors face substantial challenges with adjustment in Pakistan.
