RESUMO
This study has demonstrated that the treatment of patients with grade II-III arterial hypertension using fixed combinations of corinetec and gyzaar supplemented by acupuncture reflexotherapy resulted in a significantly more pronounced decrease of daily monitored arterial pressure than in patients who received the drug therapy without acupuncture.
Assuntos
Terapia por Acupuntura/métodos , Anti-Hipertensivos/uso terapêutico , Enalapril/uso terapêutico , Hipertensão/terapia , Losartan/uso terapêutico , Reflexoterapia/métodos , Anti-Hipertensivos/administração & dosagem , Pressão Sanguínea/efeitos dos fármacos , Monitorização Ambulatorial da Pressão Arterial , Terapia Combinada , Interpretação Estatística de Dados , Combinação de Medicamentos , Enalapril/administração & dosagem , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/tratamento farmacológico , Losartan/administração & dosagem , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoAssuntos
Hipertensão/fisiopatologia , Hipertrofia Ventricular Esquerda/tratamento farmacológico , Hipertrofia Ventricular Esquerda/fisiopatologia , Quimioterapia Combinada , Hemodinâmica , Humanos , Hipertensão/complicações , Hipertrofia Ventricular Esquerda/diagnóstico , Hipertrofia Ventricular Esquerda/etiologia , Sistema Nervoso Simpático/fisiopatologiaRESUMO
AIM: To examine correlation between platelet aggregation and the degree of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HC). MATERIAL AND METHODS: Routine clinical examination, ECG, echo-CG, measurement of platelet aggregation, routine biochemical blood tests were made in 45 HC males and 15 healthy controls. RESULTS: HC patients were characterized with high induced and spontaneous platelet aggregation which increased with left ventricular myocardial mass. In LVH, platelets were especially sensitive to the aggregation inductor U-46619, thromboxane A2 analogue. CONCLUSION: It is demonstrated that there is a positive correlation between platelet aggregation and the degree of LVH in HC patients.
Assuntos
Cardiomiopatia Hipertrófica/sangue , Agregação Plaquetária/fisiologia , Cardiomiopatia Hipertrófica/complicações , Cardiomiopatia Hipertrófica/diagnóstico , Ecocardiografia , Eletrocardiografia , Humanos , Hipertrofia Ventricular Esquerda/sangue , Hipertrofia Ventricular Esquerda/diagnóstico , Hipertrofia Ventricular Esquerda/etiologia , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de DoençaAssuntos
Hipertrofia Ventricular Esquerda/etiologia , Animais , Catecolaminas/metabolismo , Ventrículos do Coração/metabolismo , Ventrículos do Coração/patologia , Humanos , Hipertensão/complicações , Hipertensão/metabolismo , Hipertrofia Ventricular Esquerda/metabolismo , Hipertrofia Ventricular Esquerda/patologia , Miocárdio/metabolismo , Miocárdio/patologia , Sistema Renina-Angiotensina/fisiologiaRESUMO
AIM: To study platelet aggregation (PA) in patients with left ventricular hypertrophy (LVH) in essential hypertension (EH) and hypertrophic cardiomyopathy (HTCM), and to assess aspirin treatment effects. MATERIAL AND METHODS: A general clinical examination, echocardiography, 24-h monitoring of ECG and arterial pressure, bicycle exercise, test for platelet aggregation, routine blood biochemical tests were performed in 30 males with EH and LVH, 30 males with HTCM and 10 healthy controls. RESULTS: It was found that the patients had high platelet sensitivity to aggregation inductors as well as high spontaneous aggregation. LVH severity correlated positively with activation of spontaneous and induced platelet aggregation. This dependence is unrelated to arterial pressure or the disease duration. Patients with episodes of silent myocardial ischemia had a more pronounced rise in spontaneous and induced platelet aggregation than those without silent ischemia. A long-term administration of aspirin significantly lowered spontaneous and induced platelet aggregation, depression of ST segment. The above changes occurred both in HTCM and in hypertensive patients with LVH. CONCLUSION: Platelet aggregation correlates with severity of LVH and episodes of silent myocardial ischemia both in patients with hypertension, LVH and HTCM.
