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1.
Rev. cir. traumatol. buco-maxilo-fac ; 21(2): 39-42, abr.-jun. 2021. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1390997

RESUMO

Introdução: O seio maxilar é um dos seios paranasais, constituído por cavidade óssea preenchida de ar, localizado bilateralmente na maxila, próximo a região dos dentes posteriores. Dada sua localização, morfologia e fisiologia, o assoalho desse seio possui íntima relação com as raízes dos dentes posteriores. Essa estrutura possui uma membrana de revestimento e que pode ser acometida em processos de exodontia de dentes posteriores no qual existe uma relação de proximidade muito evidenciada. O alvéolo pode tornar-se uma via de comunicação entre cavidade oral e seio maxilar. Relato de Caso: O objetivo desse trabalho é descrever o relato de caso de um paciente que foi encaminhado à clínica de cirurgia Bucomaxilofacial para remoção de um fresa alojada no interior do seio maxilar direito que se deslocou durante ato de odontossecção do dente 26. A remoção do fragmento foi realizada pelo alvéolo onde, inicialmente, foi realizada a cirurgia de exodontia. O paciente em questão apresentou evolução satisfatória com ausências de sinais e sintomas de complicações relacionadas ao corpo estranho. Considerações Finais: conhecer a história é fundamental na conduta de tais casos, assim como investigar as possíveis queixas relacionadas ao quadro, por exemplo, os sinais e sintomas de uma sinusite maxilar... (AU)


Introduction: The maxillary sinus is one of the paranasal sinuses, constituted by a bone cavity filled with air, located bilaterally in the maxilla, close to the region of the posterior teeth. Given its location, morphology and physiology, the floor of this sinus is closely related to the roots of the posterior teeth. This structure has a lining membrane and can be affected in processes of extraction of posterior teeth in which there is a very evident relationship of proximity. The alveolus can become a communication route between the oral cavity and the maxillary sinus. Case Report: The purpose of this paper is to describe the case report of a patient who was referred to oral and maxillofacial surgery clinic for removal of a dental burr located inside the right maxillary sinus that was displaced during the tooth 26 extraction. Removal of the fragment was performed through the socket where, initially, extraction surgery was performed. The patient in question presented a satisfactory evolution with no signs and symptoms of complications related. Final considerations: knowing the history is important in management of these cases, as well as investigating possible complaints related to the condition, for example the signs and symptoms of a maxillary sinusitis... (AU)


Assuntos
Humanos , Masculino , Adulto , Cirurgia Bucal , Osso e Ossos , Seio Maxilar/cirurgia , Boca , Maxila , Seio Maxilar/patologia
2.
Med. oral patol. oral cir. bucal (Internet) ; 25(4): e468-e473, jul. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-196498

RESUMO

BACKGROUND: This study compared three different concentrations of EO (1.25%, 2.5% and 5%) for the treatment of oral vascular anomalies (OVAs). MATERIAL AND METHODS: This was a retrospective comparative analysis of patients with OVAs treated with EO. Anomalies smaller than 20 mm were included. The patients were treated with 1.25% (G1), 2.5% (G2), and 5% (G3) and clinical data were obtained. The number of sessions, the final volume and dose of EO were statistically analyzed to verify effectiveness and safety of the treatment. The different concentrations of EO were compared considering the number of sessions, the final volume and total dose of EO. Analysis of covariance (ANCOVA) was used to evaluate the influence of covariates on the outcomes. A p-value < 0.05 was considered significant. RESULTS: Nineteen women and 11 men with a median age of 54 years were included. The OVAs were most frequent in the lip (n = 14) and cheek (n = 9). All lesions exhibited complete clinical healing within 28 days. Patients of G3 required fewer sessions than those of G2 (p = 0.017), a lower final volume compared to the other groups (p < 0.001), and a lower total dose than G1 (p < 0.001). Patients of G1 used a lower total dose than G2 (p = 0.003). CONCLUSIONS: The concentration of 5% EO performed better than 1.25% and 2.5% for sclerotherapy of OVAs measuring up to 20 mm. This preliminary result should be the preferred concentration of EO to provide an effective and safe treatment of OVAs


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Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Ácidos Oleicos/administração & dosagem , Soluções Esclerosantes/administração & dosagem , Escleroterapia/métodos , Malformações Vasculares/terapia , Boca/irrigação sanguínea , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento , Reprodutibilidade dos Testes , Estudos Retrospectivos
3.
J Craniomaxillofac Surg ; 47(1): 106-111, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30527382

RESUMO

PURPOSE: To describe the effectiveness and safety of a sclerotherapy protocol with 5% ethanolamine oleate (EO) at 0.1 mL/3 mm for oral vascular anomalies (OVAs). Our hypothesis is that EO applied at a concentration of 5% may decrease the number of sessions necessary for clinical healing. MATERIALS AND METHODS: We describe a cohort of 15 consecutive patients. OVAs <20 mm were included. Clinical data of the OVAs were collected. Descriptive and bivariate statistical analyses were performed. RESULTS: Fifteen of the 19 OVAs were varicosities and the lower lip was the most affected site (n = 7). The median size was 6 mm, and one session was required in 89.5% of cases for clinical healing within 28 days. The pain/burning score was low (<2) for most lesions (63.1%) and the degree of satisfaction was high (>8) for all OVAs. The number of applications, final volume of drug and time to resolution differed significantly according to the size of the anomaly. CONCLUSION: The protocol with 5% EO was shown to be effective and safe to treat OVAs <20 mm, and with a decrease in the number of sessions, volume and time to resolution, without complications and with high patient satisfaction.


Assuntos
Malformações Arteriovenosas/terapia , Ácidos Oleicos/administração & dosagem , Ácidos Oleicos/uso terapêutico , Escleroterapia/métodos , Varizes/terapia , Doenças Vasculares/terapia , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Humanos , Lábio , Masculino , Pessoa de Meia-Idade , Soluções Esclerosantes/uso terapêutico , Resultado do Tratamento
4.
Belo Horizonte; s.n; 2015. 90 p. ilus, tab.
Tese em Inglês, Português | LILACS | ID: lil-790289

RESUMO

O objetivo deste trabalho foi avaliar a eficácia e segurança do agente esclerosante oleato de monoetanolamina (OM) em concentrações de 1,25%, 2,5%, 5% e na forma de espuma em estudo clínico prospectivo descritivo, no tratamento de malformações vasculares benignas (MVBs), na região de cabeça e pescoço. Na primeira fase, tratou-se 34 pacientes portadores de 36 MVBs menores que 20mm que procuram o serviço de Patologia da Faculdade de Odontologia da UFMG. Estes pacientes receberam protocolo de tratamento com aplicação de OM nas concentrações de 1,25% (n=10), 2,5% (n=9) descritos por Johann et al(2005) e 5% (n=19) nas doses 1ml/cm, 1ml/cm e 0,1ml/3mm respectivamente...


Assuntos
Humanos , Masculino , Feminino , Ácido Oleico/uso terapêutico , Escleroterapia , Malformações Vasculares , Lesões do Sistema Vascular , Protocolos Clínicos , Interpretação Estatística de Dados
5.
J Craniofac Surg ; 25(4): e324-6, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24978688

RESUMO

An unusual presentation of a focal osteoporotic bone marrow defect (FOBMD) of the mandible mimicking a cystic lesion is documented. A definitive diagnosis could be established only on the basis of the histopathologic evaluation. A 66-year-old Brazilian woman was referred by her dentist for well-defined radiolucency of the mandibular molar region suggesting a cystic lesion of odontogenic origin. The computed tomography scan confirmed that the lesion did not affect the corticals. The biopsy confirmed the diagnosis of FOBMD. The diagnostic difficulty in the current case is obvious, because FOBMD, usually exhibiting an ill-defined radiolucency, is seldom suspected preoperatively when a differential diagnosis is considered for focal well-defined radiolucent areas in the jaws.


Assuntos
Doenças da Medula Óssea/diagnóstico , Cistos/diagnóstico , Doenças Mandibulares/diagnóstico , Osteoporose/diagnóstico , Idoso , Diagnóstico Diferencial , Feminino , Humanos
6.
Oral Maxillofac Surg ; 18(4): 459-64, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24370576

RESUMO

OBJECTIVE: The aim of this work is to demonstrate the accidents and complications rates on third molars surgeries performed by senior dentistry students. METHODS: A retrospective study of 122 patient charts submitted to third molars surgeries was done. Patient age, gender, dental in arch position, and accidents/complications were considered with the charts presenting incomplete dates being excluded from the study. After all, 88 patients (210 surgeries) were included. RESULTS: The majority of the patients were female (70.4 %), with the average age of 24 years. Mandibular molars represented more than half of the surgical procedures (56.2 %), with teeth at vertical position the most found (60.3 %). The cases of accidents and complications totalized 10.4 % of all performed procedures, being hemorrhage (1.9 %), root fractures (1.9 %), and maxillary tuberosity fracture (1.9 %) the most found. Suture dehiscence (1.4 %), dry socket (1.4 %), oroantral communications (0.9 %), paresthesia (0.9 %), and infection (0.4 %) were also observed. CONCLUSIONS: Surgeons' inexperience was not considered a determinant factor to modify the rates of accidents and complications at third molars surgeries when compared to previous works developed by experienced surgeons. It is important to highlight the necessity of the students' knowledge of the most adequate treatments of each of the accidents and complications.


Assuntos
Acidentes , Dente Serotino/cirurgia , Complicações Pós-Operatórias , Estudantes de Odontologia , Extração Dentária/efeitos adversos , Brasil , Alvéolo Seco/etiologia , Feminino , Humanos , Masculino , Mandíbula/cirurgia , Fraturas Maxilares/etiologia , Hemorragia Bucal/etiologia , Fístula Bucoantral/etiologia , Parestesia/etiologia , Estudos Retrospectivos , Deiscência da Ferida Operatória/etiologia , Infecção da Ferida Cirúrgica/etiologia , Fraturas dos Dentes/etiologia , Raiz Dentária/lesões , Adulto Jovem
7.
Gerodontology ; 29(2): e1136-9, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21029155

RESUMO

BACKGROUND: Myiasis is the invasion of living tissue of humans and other mammals by eggs or maggots of flies of the order of Diptera. It occurs mainly in the Tropics and is associated with inadequate public and personal hygiene. Oral myiases in an older man appears to be rare. OBJECTIVE: To relate a case of oral myiases in a debilitated older man treated by mechanical removal of the maggots, identifying the adult insect that caused the infestation. METHODS: The diagnosis of oral myiasis was established by the clinical examination and it was detected that the infestation involved only soft tissue and the sinus cavity. The patient was submitted to two mechanical removal of the visible maggots. RESULTS: Total of 110 maggots was removed from the oral cavity of the patient and adult insects was identified as belonging to the Calliphoridae Family, Cochliomyia hominivorax species. The patient died two days after the second procedure by severe systemic complications. CONCLUSIONS: The mechanic removal and the identification of the maggots must be adopted as soon as possible to prevent further tissue damage and bacterial infection in cases of oral myiasis. Special attention should be given to the debilitated old patients that are particularly susceptible to oral myiasis infestation.


Assuntos
Doenças da Boca/parasitologia , Miíase/diagnóstico , Idoso de 80 Anos ou mais , Animais , Dípteros/classificação , Evolução Fatal , Doenças da Gengiva/parasitologia , Humanos , Larva/anatomia & histologia , Masculino , Seio Maxilar/parasitologia , Mucosa Bucal/parasitologia , Doenças dos Seios Paranasais/parasitologia
8.
Artigo em Inglês | MEDLINE | ID: mdl-21330166

RESUMO

OBJECTIVE: The aim of this study was to identify the behavior of masticatory muscles after fractures of the zygomatico-orbital complex (ZOC) and subsequent surgical treatment, by using analyses of bite force, electromyography (EMG), and mandible mobility during a 6-month period after surgery. STUDY DESIGN: Five patients with fractured ZOCs treated surgically by using an intraoral approach and fixation exclusively in the region of the zygomaticomaxillary buttress were evaluated. The control group included 12 other patients. During postoperative follow-up, bite force, mandible mobility, and EMG analysis of the masticatory muscles were evaluated. RESULTS: There was an increase in bite force with time, but a decline in EMG activity during the same period. In the mandible mobility analysis, only maximum mouth-opening values increased significantly after the surgical treatment. CONCLUSIONS: The masticatory musculature, according to bite force and EMG, returned to its normal condition by the second month after surgery, and maximum mouth opening was observed after the first month.


Assuntos
Força de Mordida , Músculos da Mastigação/fisiologia , Fraturas Orbitárias/fisiopatologia , Fraturas Zigomáticas/fisiopatologia , Adulto , Estudos de Casos e Controles , Eletromiografia , Feminino , Fixação Interna de Fraturas , Humanos , Masculino , Mandíbula/fisiologia , Movimento , Fraturas Orbitárias/cirurgia , Período Pós-Operatório , Amplitude de Movimento Articular , Recuperação de Função Fisiológica , Adulto Jovem , Fraturas Zigomáticas/cirurgia
9.
Rev. cir. traumatol. buco-maxilo-fac ; 10(4): 45-54, set.-dez. 2010. graf, tab
Artigo em Português | LILACS | ID: lil-792112

RESUMO

O objetivo deste artigo é o de demonstrar as taxas de acidentes e complicações nas cirurgias de terceiros molares realizadas por alunos do último ano do curso de graduação em Odontologia. METODOLOGIA: a análise retropectiva do prontuário de 122 pacientes submetidos à extração dos terceiros molares foi realizada. A idade dos pacientes, o gênero, a posição do dente no arco e os acidentes e complicações decorrentes das cirurgias foram considerados. Prontuários com dados incompletos foram excluídos do estudo. Do total, 88 pacientes foram incluídos, totalizando 210 extrações. RESULTADOS: A maioria dos pacientes era do gênero feminino (70,47%), com idade média de 24 anos. Os molares inferiores corresponderam a mais da metade dos procedimentos cirúrgicos (56,2%), senda a posição vertical (60,37%) a mais encontrada. Os casos de acidentes e/ou complicações totalizaram 10,47% dos procedimentos, sendo a hemorragia (2,38%), as fraturas radiculares (1,90%) e as fraturas da tuberosidade maxilar (1,90%) as mais encontradas. Outros acidentes/complicações encontrados foram deiscência de sutura (1,45%), comunicação buco-sinusal (0,95%), parestesia (0,95%), alveolite (0,47%) e infecção (0,47%). CONCLUSÕES: a inexperiência do cirurgião não pôde ser considerada como um fator determinante para o aumento das taxas de acidentes e complicações em exodontias dos terceiros molares, tendo em vista a semelhança dos resultados deste trabalho com estudos desenvolvidos por cirurgiões experientes. É importante salientar a necessidade do conhecimento por parte dos alunos dos tratamentos mais adequados para os diferentes acidentes e complicações encontradas.


The aim of this work is to demonstrate accidents and complications rates on third molars surgeries performed by senior dentistry students. METHODS: a restrospective study of 122 patient charts submitted to third molars surgeries was done. Patient age, gender, dental in arch position, and accidents/complications were considered with the charts presenting incomplete dates being excluded from study. After all, 88 patients (210 surgeries) were included. RESULTS: the majority of the patients were female (70,47%), with average age of 24 years old. Mandibular molars represented more than half of the surgical procedures (56,2%), with teeth at vertical position the most found (60,37%). The cases of accidents and complications totalized 10,47% of all performed procedures, being bleeding (2,38%), root fractures (1,90%) and maxilar tuberosity (1,90%) the most found. Suture dehiscence (1,45%), oro-antral comunications (0,95%), paresthesia (0,95%), alveolitis (0,47%) and infection (0,47%) were also observed. CONCLUSIONS: surgeons inexperience was not considered a determinant factor to modify the rates of accidents and complications at third molars surgeries when compared to previous works developed by experienced surgeons. Is important to highlight the necessity of the students knowledge of the most adequate treatments of each of the accidents and complications.

10.
Head Neck Pathol ; 3(4): 320-6, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20596853

RESUMO

This report presents a case of osteopetrosis in a 25-year-old male, which was complicated by the development of osteomyelitis in the maxilla and mandible following traumatic injury and tooth extractions. The osteomyelitis in the mandible was refractory to marginal resection and antibiotic therapy. Partial resection with mandible reconstruction was then carried out. Light and backscattered electron scanning microscopy revealed sclerosis of spongy bone and variations in mineral density of the bone matrix. There was also a prominent periosteal bone formation in regions affected by osteomyelitis. An 18-month follow-up showed absence of active infections in the face and oral structures, with a focal area of bone exposure in the right parasymphysis. However, development of anemia and bone marrow deficiency will likely affect prognosis. The importance of preventive oral health care and dental/periodontal managements in osteopetrosis is emphasized.


Assuntos
Doenças Maxilomandibulares/complicações , Osteomielite/complicações , Osteomielite/patologia , Osteopetrose/complicações , Osteopetrose/patologia , Adulto , Humanos , Doenças Maxilomandibulares/patologia , Doenças Maxilomandibulares/cirurgia , Masculino , Microscopia Eletrônica de Varredura , Procedimentos Cirúrgicos Bucais , Osteomielite/cirurgia , Osteopetrose/cirurgia , Extração Dentária/efeitos adversos
11.
Braz Dent J ; 19(2): 165-70, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18568233

RESUMO

McCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-glass radiographic appearance, and were diagnosed as having fibrous dysplasia and endocrine disorders. The patient of Case 1 had fibrous dysplasia on the upper and lower limbs, thorax, face and cranium, early puberty, hyperglycemia, hyperthyroidism and high serum alkaline phosphatase levels. The patient of Case 2 presented lesions on the upper limbs and evident endocrine disorders. In both cases presented in this article, the initial exam was made because of the mandibular lesion. However, a diagnosis of fibrous dysplasia must lead to investigation of the involvement of other bones, characterizing polyostotic fibrous dysplasia, which is manifested in a number of diseases. An accurate differential diagnosis is mandatory to determine the best treatment approach for each case.


Assuntos
Displasia Fibrosa Poliostótica/diagnóstico , Doenças Mandibulares/diagnóstico , Densidade Óssea/fisiologia , Núcleo Celular/patologia , Criança , Colágeno , Diagnóstico Diferencial , Assimetria Facial/diagnóstico , Ossos Faciais/patologia , Feminino , Fibroblastos/patologia , Displasia Fibrosa Poliostótica/patologia , Seguimentos , Humanos , Doenças Mandibulares/patologia , Pessoa de Meia-Idade , Radiografia Panorâmica , Crânio/patologia , Tomografia Computadorizada por Raios X
12.
Braz. dent. j ; 19(2): 165-170, 2008. ilus
Artigo em Inglês | LILACS | ID: lil-484955

RESUMO

McCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-glass radiographic appearance, and were diagnosed as having fibrous dysplasia and endocrine disorders. The patient of Case 1 had fibrous dysplasia on the upper and lower limbs, thorax, face and cranium, early puberty, hyperglycemia, hyperthyroidism and high serum alkaline phosphatase levels. The patient of Case 2 presented lesions on the upper limbs and evident endocrine disorders. In both cases presented in this article, the initial exam was made because of the mandibular lesion. However, a diagnosis of fibrous dysplasia must lead to investigation of the involvement of other bones, characterizing polyostotic fibrous dysplasia, which is manifested in a number of diseases. An accurate differential diagnosis is mandatory to determine the best treatment approach for each case.


A Síndrome de McCune-Albright é caracterizada pela tríade manchas café-com-leite na pele, displasia fibrosa poliostótica e endocrinopatias. Este artigo apresenta dois casos de Síndrome de McCune-Albright em uma mulher de meia idade e em uma menina. Ambos apresentavam manchas café-com-leite na face e em outras partes do corpo, expansão da mandíbula com área radiopaca-radiolúcida com aspecto de vidro despolido na radiografia, com o diagnóstico de displasia fibrosa, e desordens endócrinas. O paciente do Caso 1 apresentava displasia fibrosa nos membros inferiores e superiores, tórax, face e crânio, puberdade precoce, hiperglicemia, hipertireoidismo e elevação da fosfatase alcalina no sangue. O paciente do Caso 2 apresentava lesões nos membros superiores e desordem endócrina evidente. Em ambos os casos apresentados neste artigo, o exame inicial foi realizado devido à lesão mandibular. Contudo, o diagnóstico de displasia fibrosa deve conduzir a pesquisa de envolvimento de outros ossos, caracterizando a displasia fibrosa poliostótica, que se manifesta em um grande número de doenças. O diagnóstico diferencial preciso é fundamental para determinar o tratamento adequado a cada caso.


Assuntos
Criança , Feminino , Humanos , Pessoa de Meia-Idade , Displasia Fibrosa Poliostótica/diagnóstico , Doenças Mandibulares/diagnóstico , Densidade Óssea/fisiologia , Colágeno , Núcleo Celular/patologia , Diagnóstico Diferencial , Seguimentos , Assimetria Facial/diagnóstico , Ossos Faciais/patologia , Fibroblastos/patologia , Displasia Fibrosa Poliostótica/patologia , Doenças Mandibulares/patologia , Radiografia Panorâmica , Crânio/patologia , Tomografia Computadorizada por Raios X
13.
Neuropharmacology ; 51(1): 37-43, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16620880

RESUMO

Mechanical hyperalgesia induced in rat paws by carrageenan (250microg) was modified by pre-treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib and SC236. These inhibitors raised the nociceptive threshold above the normal, non-inflamed, level, inducing a state of hypoalgesia. Such hypoalgesia was observed in different strains of rat (Holtzman, Wistar and Sprague-Dawley) and after different modes of administration of the COX-2 inhibitor (locally, in the paw, or systemically). A selective inhibitor of COX-1 (SC 560; 1-10mg kg(-1)) decreased hyperalgesia but did not induce hypoalgesia. Pre-treatment with naltrexone (3mg kg(-1)), an opioid receptor antagonist, did not affect carrageenan-induced hyperalgesia but abolished the hypoalgesic effects of COX-2 inhibitors, without diminishing the anti-hyperalgesic effect of indomethacin. In rats made tolerant to the anti-nociceptive effects of morphine, all anti-nociceptive effects of SC236 were abolished but the anti-hyperalgesic effects of indomethacin or SC 560 were unaffected. We conclude that, in our model of inflammatory hyperalgesia, the anti-nociceptive effect of selective COX-2 inhibitors involved the participation of endogenous opioids.


Assuntos
Analgésicos , Inibidores de Ciclo-Oxigenase 2/farmacologia , Endorfinas/fisiologia , Dor/tratamento farmacológico , Dor/fisiopatologia , Analgésicos Opioides/farmacologia , Animais , Carragenina , Ciclo-Oxigenase 1/fisiologia , Inibidores de Ciclo-Oxigenase 2/administração & dosagem , Inibidores de Ciclo-Oxigenase/farmacologia , Dinoprostona/administração & dosagem , Dinoprostona/farmacologia , Tolerância a Medicamentos , Edema/induzido quimicamente , Edema/complicações , , Hiperalgesia/induzido quimicamente , Hiperalgesia/psicologia , Indometacina/farmacologia , Injeções , Injeções Subcutâneas , Masculino , Morfina/farmacologia , Naltrexona/farmacologia , Antagonistas de Entorpecentes/farmacologia , Dor/etiologia , Medição da Dor/efeitos dos fármacos , Pirazóis/farmacologia , Ratos , Ratos Sprague-Dawley , Ratos Wistar , Transdução de Sinais/efeitos dos fármacos , Especificidade da Espécie
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