Long responders to estramustine monophosphate. Report of two cases and literature review. / Repondedores a largo plazo a Estramustina monofosfato. A propósito de dos casos. Revisión bibliográfica.

OBJECTIVE: Estramustine is an stable estradiol and nitrogenated mustard conjugatewith antymicotic properties. Currently, with the appearance of chemotherapy and new molecules, estramustin acetate is not a drug of choice for castration resistant prostate cancer. METHODS: We describe two patients with castration resistant prostate cancer under treatment with estramustine acetate and complete biochemical response and stable disease. We review the literature to elucidate if the drug should be stopped and changed for the new molecules that have demonstrated survival increase. RESULTS: To our knowledge, there are not data in the literature to either solve the questions posed or shed light regarding cumulative toxicity due to prolongued use of estramustine acetate. CONCLUSIONS: We recognize that these clinical cases do not translate that estramustine acetate is a first line treatment for patients with CRPC. Nevertheless, they translate the heterogeneity of CRPC. It would be interesting to investigate the combination of new agents with estramustine acetate as well as the search of biomarkers that enable selection of candidates who could respond to estramustine acetate.

OBJETIVO: La estramustina es un conjugado estable de estradiol y una mostaza nitrogenada que tiene propiedades antimitóticas. Actualmente, con la aparición de la quimioterpia y las nuevas moléculas, el acetato de estramustina -no es un fármaco de elección en el cáncer de próstata resistente a castración.MÉTODO: Describimos dos pacientes con cáncer de próstata resistente a la castración en tratamiento con acetato de estramustina, y con una respuesta bioquímica completa y enfermedad estable. Revisamos la literatura para dilucidar si se debería retirar el acetato de estramustina y cambiar por las nuevas moléculas que han demostrado un aumento de supervivencia. RESULTADO: Hasta donde llega nuestro conocimiento, no hay datos en la literatura que resuelvan las dudas planteadas y tampoco que aporten luz en cuanto a la toxicidad acumulada por el uso prolongado del acetato de estramustina.CONCLUSIÓN: Somos conscientes de que estos casos clínicos no traducen que el acetato de estramustina sea un tratamiento de primera línea para los pacientes con cáncer de próstata resistente a la castración. Sin embargo, traducen la heterogeneidad del CPRC. Sería interesante investigar la combinación de los nuevos agentes con el acetato de estramustina así como la búsqueda de biomarcadores que permitan la selección de los candidatos que podrían responder al acetato de estramustina.

Long responders to estramustine monophosphate. Report of two cases and literature review / Repondedores a largo plazo a Estramustina monofosfato. A propósito de dos casos. Revisión bibliográfica

Objective: Estramustine is an stable estradiol and nitrogenated mustard conjugatewith antymicotic properties. Currently, with the appearance of chemotherapy and new molecules, estramustin acetate is not a drug of choice for castration resistant prostate cancer. Methods: We describe two patients with castration resistant prostate cancer under treatment with estramustine acetate and complete biochemical response and stable disease. We review the literature to elucidate if the drug should be stopped and changed for the new molecules that have demonstrated survival increase. Results: To our knowledge, there are not data in the literature to either solve the questions posed or shed light regarding cumulative toxicity due to prolongued use of estramustine acetate. Conclusions: We recognize that these clinical cases do not translate that estramustine acetate is a first line treat ment for patients with CRPC. Nevertheless, they translate the heterogeneity of CRPC. It would be interesting to investigate the combination of new agents with estramustine acetate as well as the search of biomarkers that enable selection of candidates who could respond to estramustine acetat. Conclusions: We recognize that these clinical cases do not translate that estramustine acetate is a first line treat

OBJETIVO: La estramustina es un conjugado estable de estradiol y una mostaza nitrogenada que tiene propiedades antimitóticas. Actualmente, con la aparición de la quimioterpia y las nuevas moléculas, el acetato de estramustina -no es un fármaco de elección en el cáncer de próstata resistente a castración. MÉTODO: Describimos dos pacientes con cáncer de próstata resistente a la castración en tratamiento con acetato de estramustina, y con una respuesta bioquímica completa y enfermedad estable. Revisamos la literatura para dilucidar si se debería retirar el acetato de estramustina y cambiar por las nuevas moléculas que han demostrado un aumento de supervivencia. RESULTADO: Hasta donde llega nuestro conocimiento, no hay datos en la literatura que resuelvan las dudas planteadas y tampoco que aporten luz en cuanto a la toxicidad acumulada por el uso prolongado del acetato de estramustina. CONCLUSIÓN: Somos conscientes de que estos casos clínicos no traducen que el acetato de estramustina sea un tratamiento de primera línea para los pacientes con cáncer de próstata resistente a la castración. Sin embargo, traducen la heterogeneidad del CPRC. Sería interesante investigar la combinación de los nuevos agentes con el acetato de estramustina así como la búsqueda de biomarcadores que permitan la selección de los candidatos que podrían responder al acetato de estramustina

Comparison of permanent (125)I seeds implants with two different techniques in 500 cases of prostate cancer.

PURPOSE: To perform a comparative study of 500 consecutive (125)I seeds implants for intracapsular prostate carcinoma with two techniques differing in terms of both strand implantation and planning. MATERIAL AND METHODS: From 2002 to 2007 we performed 250 implants with fixed stranded seeds (RapidStrand™) and a preplanning system and from 2007 to 2010, 250 with real-time and ProLink™ system. Mean age was 68 and 66, respectively, median PSA (prostate-specific antigen) 7.3 and 7.2, stage T1-T2a in 98% and 94%, and Gleason ≤ 6 in 96% and 86%. Low risk cases were 81% and 71%. The prescribed dose was 145 Gy to the prostate volume, or 108 Gy plus EBRT 46 Gy in some intermediate risk cases. Hormonal treatment was given to 42% and 28%. RESULTS: Median follow-up was 48 and 47 months, respectively, 14 patients in the first group and 7 patients in the second developed biochemical failure (BF). Actuarial biochemical relapse-free survival (bRFS) at 5 years increased from 90.2% to 97.2% (low risk from 91.3% to 97.2%, intermediate risk from 84.2% to 97.1%). Biochemical failure was independent of hormone treatment. Rectal complications were G1-2 in 1.2% and 5.2%, respectively. A urinary catheter was necessary in 6.9% and 9.6%, and urethral resection in 1.9% and 4.4%. Genitourinary toxicity was G1-2 in 4.6% and 12%, G3-4 in 1.9% and 4.8%. An assessment of mean D90 in a sample of patients showed that the dosimetry in postoperative planning based on CT improved from a mean D90 of 143 Gy to 157 Gy. CONCLUSIONS: The outcome of patients with low risk prostate carcinoma treated with (125)I seed is very good with low complications rate. The real-time approach in our hands achieved a more precise seed implantation, better dosimetry, and a statistically non-significant better biochemical control. We have made this our standard technique.

Biopsia dinámica de ganglio centinela en cáncer de pene. Indicaciones, técnica y resultados en un centro oncológico español / Dynamic sentinel node biopsy in penile cancer. Indications, technique and results in a spanish oncological center

OBJETIVO: El cáncer de pene tiene una diseminación predominantemente linfática. La afectación metastásica de los ganglios linfáticos condiciona el pronóstico de esta enfermedad y la linfadenectomía inguinal tiene tanto valor pronóstico como terapéutico. Los pacientes de riesgo alto e intermedio con ganglios no palpables se beneficiarán de un diagnóstico preciso mediante la biopsia selectiva de ganglio centinela (BDGC) con una mínima agresividad quirúrgica. MÉTODOS: Revisión retrospectiva de nuestra experiencia en biopsia dinámica de ganglio centinela en cáncer de pene desde noviembre de 1999 a julio de 2014. RESULTADOS: Hemos realizado este procedimiento en 33 pacientes, técnicamente con éxito en 29 (88%). Los pacientes no sometidos a linfadenectomía por BDGC positiva han sido seguidos una media de 60.4 meses (mediana 59, rango 5-145). En 20 pacientes se realizó BDGC de manera simultánea al tratamiento quirúrgico de la lesión primaria y en 13 con posterioridad. El tiempo transcurrido en estos casos fue de 5,5 meses (mediana 5, rango: 2-12). En 6 (18,8%) de los 29 pacientes biopsiados con éxito, se observó metástasis en alguno de sus ganglios identificados como centinela. Dos pacientes fueron Falsos Negativos (6,25%). La Sensibilidad (S), Especificidad (E), Valor Predictivo Positivo (VPP) y Valor Predictivo Negativo (VPN) de las BDGC llevadas a cabo con éxito ha sido de: 66, 100, 100 y 93%, respectivamente. Conclulsión: La BDCG permite un correcto estadiaje ganglionar evitando la morbilidad de la linfadenectomía inguinal. La tasa de fracaso técnico y de Falsos Negativos (FN) es baja y puede considerarse como técnica diagnóstica de elección en cáncer de pene de riesgo alto e intermedio con ganglios impalpables

OBJECTIVE: Penile cancer has a predominantly lymphatic dissemination. Lymph nodes metastatic involvement conditions disease prognosis and inguinal lymph node dissection has both prognostic and therapeutic value. High and intermediate risk patients with non-palpable lymph nodes will benefit of a precise diagnosis by means of selective sentinel node biopsy with minimal surgical aggressiveness. Methos: Retrospective review of our experience on dynamic sentinel node biopsy in penile cancer from November 1999 to July 2014. RESULTS: We performed this procedure in 33 patients, technically successful in 29 (88%). The patients who did not undergo lymph node dissection due to positive sentinel node biopsy have been followed a mean of 60.4 months (Median 59, range 5-145). 20 patients underwent simultaneous sentinel node biopsy and surgical treatment of the primary lesion and in 13 it was performed posteriorly. In these cases the time lapse was 5.5 months (median 5, range 2-12). In 6 (18.9%) of the 29 patients successfully biopsied, metastasis was founded in any of the lymph nodes identified as sentinel. Two patients were false negative (6,25%). Sensitivity (S), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of successfully performed sentinel node biopsies were 66, 100, 100 and 93%, respectively. CONCLUSION: Sentinel node biopsy enables a correct lymph node staging avoiding the morbidity of inguinal lymph node dissection. The rate of technical failure and false negative results is low and it may be considered the diagnostic technique of choice in high and intermediate risk penile cancer with non-palpable lymph nodes

[Dynamic sentinel node biopsy in penile cancer. Indications, technique and results in a Spanish oncological center]. / BIOPSIA DINÁMICA DE GANGLIO CENTINELA EN CÁNCER DE PENE. INDICACIONES, TÉCNICA Y RESULTADOS EN UN CENTRO ONCOLÓGICO ESPAÑOL.

OBJECTIVE: Penile cancer has a predominantly lymphatic dissemination. Lymph nodes metastatic involvement conditions disease prognosis and inguinal lymph node dissection has both prognostic and therapeutic value. High and intermediate risk patients with non-palpable lymph nodes will benefit of a precise diagnosis by means of selective sentinel node biopsy with minimal surgical aggressiveness. METHODS: Retrospective review of our experience on dynamic sentinel node biopsy in penile cancer from November 1999 to July 2014. RESULTS: We performed this procedure in 33 patients, technically successful in 29 (88%). The patients who did not undergo lymph node dissection due to positive sentinel node biopsy have been followed a mean of 60.4 months (Median 59, range 5-145). 20 patients underwent simultaneous sentinel node biopsy and surgical treatment of the primary lesion and in 13 it was performed posteriorly. In these cases the time lapse was 5.5 months (median 5, range 2-12). In 6 (18.9%) of the 29 patients successfully biopsied, metastasis was founded in any of the lymph nodes identified as sentinel. Two patients were false negative (6,25%). Sensitivity (S), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of successfully performed sentinel node biopsies were 66, 100, 100 and 93%, respectively. CONCLUSION: Sentinel node biopsy enables a correct lymph node staging avoiding the morbidity of inguinal lymph node dissection. The rate of technical failure and false negative results is low and it may be considered the diagnostic technique of choice in high and intermediate risk penile cancer with non-palpable lymph nodes.

Bladder preservation in selected patients with muscle-invasive bladder cancer by complete transurethral resection of the bladder plus systemic chemotherapy: long-term follow-up of a phase 2 nonrandomized comparative trial with radical cystectomy.

BACKGROUND: Many phase 2 bladder-sparing programmes using transurethral resection of the bladder (TURB) plus chemotherapy or radio-chemotherapy have been undertaken, but some controversies remain. OBJECTIVE: To determine the efficacy of complete TURB plus three cycles of cisplatin-based chemotherapy in selected patients with muscle-invasive bladder cancer (MIBC). DESIGN, SETTING, AND PARTICIPANTS: A phase 2 nonrandomized trial was designed that included patients with MIBC who underwent complete TURB with positive biopsies of the tumour bed. Patients with negative biopsies of the tumour bed, with macroscopically residual tumour, with hydronephrosis, or with distant metastasis were excluded from this trial. Patients included in this trial were offered three cycles of systemic chemotherapy or radical cystectomy (RC). Clinical response (cR) was denoted by either no tumour or the presence of Ta1-Tis bladder tumour at 3-mo evaluation; clinical non-response (cNR) was denoted by cases of muscle-invasive tumour or distant metastasis. Of 146 patients who entered this trial, 75 choose the bladder-sparing programme and 71 chose RC. MEASUREMENTS: At 5 yr and 10 yr, the cancer-specific survival (CSS) rate was 64.5% and 59.8%, respectively, with no significant difference compared to the RC arm (p=0.544). The progression-free survival with bladder preserved was 52.6% and 34.5%, respectively. In multivariate analysis, cR was the only predictive factor for survival (p=0.001) and bladder preservation (p=0.000). RESULTS AND LIMITATIONS: This was not a randomized trial, and patients were included over 16 yr. However, no modifications were made to the therapy schedule except from chemotherapy schemes considered standard at the time. CONCLUSIONS: Patients with microscopic residual cancer after complete TURB seem to be good candidates for the bladder-sparing programme using three cycles of systemic chemotherapy, with CSS comparable to RC.

Envejecimiento y hospitalización domiciliaria / No disponible

Objetivo: Analizar las características de la población diana de hospitalización domiciliaria (HD), su estructura y competencia. Método: Estudio descriptivo retrospectivo. Resultados: El 78,8% de los pacientes son mayores de 65 años. Los procesos crónicos representan el 46,9%. Para los grupos de causas patológicas, el 52,1% se incluyen en la categoría de otras pluripatologías, seguido de los tumores y neoplasias (28%) y las enfermedades del aparato circulatorio (18,8%). La principal puerta de entrada en HD fue la UMCE (53,0%) y el principal destino de los pacientes fue la atención primaria (62,0%). Discusión: Los ancianos con plurupatologias crónicas o terminales tienen en la HD una estrategia eficiente, ya que son pacientes que por su complejidad pueden superar las posibilidades de tratamiento en atención primaria. Se concluye que hay un problema de comunicación entre la atención primaria y el hospital, que obviamente se proyecta hacia los pacientes y hacia la calidad y efectividad de la asistencia sanitaria (AU)

Objective: This study aimed to analyze the characteristics of a Hospital Home Care target population, its structure and competence. Methods: Retrospective descriptive study. Results: The results of this study indicated that 78,8% of the patients were more than 65 years old Chronic process represented 46,9% of the cases. Among the pathology causes group, 52,1% were included in the pluripathologies category, followed by tumors and neoplasies (28%) and by circulatory diseases (18,8%). The main admission way to Hospital Home Care was by the Short Staying Medical Unity (53%) and the main destination of the patients was to the primary attention (62%).Discussion: Aged people with chronic or terminal pluripathologies met an efficient strategy in Hospital Home Care, considering that due to their own complexities, they can surpass treatment possibilities in primary attention. In conclusion, there is hospital, which clearly is projected to patients and to sanitary assistance quality and effectiveness (AU)

[Home hospitalization in light of demographic changes and new health challenges]. / La hospitalización domiciliaria ante los cambios demográficos y nuevos retos de salud.

OBJECTIVE: Today, the most important demographic change taking place is the rapid aging of the population. While this phenomenon is having a growing and profound impact on all spheres of society, its greatest impact is in the health area, affecting all levels of health care and leading to the need for new resources and new structures. Out of that, in many countries have come different alternatives as well as in-patient, outpatient, and in-home programs that are geared toward improving health care and helping set priorities. One of these new initiatives is home hospitalization, or home health care. One objective of this study was to describe and analyze the characteristics of a population in Spain that was assisted through home hospitalization (HH). Another objective of the study was to comment on the role that HH can play as a mechanism for integration and coordination between health care levels, in the face of the challenges occurring with the reorganization of health care policies and programs, especially those directed at the elderly. METHODS: A retrospective descriptive study was done of patients assisted through HH in Sanitary Area 9 of the Autonomous Community of Valencia, which is on the eastern coast of Spain. The area's population was 321,361, of whom 60,079 (18.7%) were 60 or older, including 43,044 (13.4%) who were 65 or older. A descriptive study of the analyzed variables was done, with the mean and standard deviation being computed for quantitative variables, and the absolute and relative frequencies (percentages) being calculated for the qualitative variables. RESULTS: Of the patients studied, 78% of them were 65 or older, with an average age of 73 years. They were predominantly women. Of the total group, 72% of them had chronic diseases, and 67% had at least one associated secondary diagnosis. There was an important problem of communication between the two principal levels of care, primary care and hospital care, which obviously had an impact on the patients and on the quality and effectiveness of their health care. Furthermore, it was found that HH finds its greatest utility with and is an effective tool for an adult or elderly population that has multiple chronic degenerative or terminal diseases. CONCLUSIONS: The results of this study highlight the need to create or strengthen channels and mechanisms for interinstitutional communication that will guarantee continuity of care. The ongoing, effective care of the health and well-being of elderly persons requires different levels of health interventions. This care should be comprehensive, adequate, integrated, of high quality, humanized, timely, and coordinated between the two principal levels of health care. In the final analysis, these factors will determine the quality of the health care for geriatric patients and the capacity to solve their health problems.

La hospitalización domiciliaria ante los cambios demográficos y nuevos retos de salud / Home hospitalization in light of demographic changes and new health challenges

Objetivos. En la actualidad, el fenómeno demográfico más importante es el rápido envejecimiento de la población, que tiene un creciente y profundo impacto en todos los ámbitos de la sociedad, aunque su mayor trascendencia es en la sanidad, tanto por su repercusión en todos los niveles asistenciales como por la necesidad de nuevos recursos y estructuras. De ahí que se hayan desarrollado en muchos países diferentes alternativas y programas institucionales, ambulatorios y domiciliarios, encaminados a mejorar la situación sanitaria y a auxiliar en el proceso de establecer prioridades. La hospitalización domiciliaria (HD) es una de ellas. El objetivo de este estudio consistió en describir y analizar las características de la población asistida en HD, y en comentar el papel de la HD como mecanismo de integración y coordinación entre niveles, frente al reto de la reorganización de políticas y proyectos de atención sanitaria, especialmente los dirigidos a la población anciana. Métodos. Se realizó un estudio descriptivo, retrospectivo, de una serie de pacientes asistidos en HD en el área sanitaria número 9 de la Comunidad Valenciana, España, con una población de referencia de 321 361 habitantes, de los cuales 60 079 (18,7%) son personas de 60 años o más, y 43 044 (13,4%), de 65 años o más. Se realizó un estudio descriptivo de las variables analizadas, calculándose la media y la desviación estándar para las variables cuantitativas, y las frecuencias absoluta y relativa (porcentaje) para las variables cualitativas. Resultados. El perfil de los pacientes estudiados corresponde a ancianos (el 78% con 65 años o más; media de 73 años), predominantemente del sexo femenino, con enfermedades crónicas (72%) y múltiples enfermedades asociadas (el 67% tenía al menos un diagnóstico secundario asociado). Se constató la existencia de un importante problema de comunicación entre los dos principales niveles de atención (primaria y hospitalaria), que obviamente repercute en los pacientes y en la calidad y eficacia de la asistencia sanitaria. Asimismo, se verificó que la HD encuentra todo su significado en la población adulta o anciana con múltiples enfermedades crónicas degenerativas o terminales, en la que ha demostrado ser una herramienta eficiente. Conclusiones. Se destaca la necesidad de crear o potenciar los canales y mecanismos de comunicación interinstitucional que garanticen la continuidad del proceso asistencial. La asistencia continua y eficaz de la salud y bienestar del anciano requiere diferentes niveles de intervención sanitaria y debe estar basada en lo que hoy es un objetivo inaplazable: la atención integral, adecuada, de calidad, humanizada, oportuna y basada en una asistencia integrada y coordinada entre los dos principales niveles de atención sanitaria. Son estos factores los que, en última instancia, determinan la calidad de la asistencia y la capacidad resolutiva de los problemas asistenciales planteados en la atención al paciente geriátrico.

Objective. Today, the most important demographic change taking place is the rapid aging of the population. While this phenomenon is having a growing and profound impact on all spheres of society, its greatest impact is in the health area, affecting all levels of health care and leading to the need for new resources and new structures. Out of that, in many countries have come different alternatives as well as in-patient, outpatient, and in-home programs that are geared toward improving health care and helping set priorities. One of these new initiatives is home hospitalization, or home health care. One objective of this study was to describe and analyze the characteristics of a population in Spain that was assisted through home hospitalization (HH). Another objective of the study was to comment on the role that HH can play as a mechanism for integration and coordination between health care levels, in the face of the challenges occurring with the reorganization of health care policies and programs, especially those directed at the elderly. Methods. A retrospective descriptive study was done of patients assisted through HH in Sanitary Area 9 of the Autonomous Community of Valencia, which is on the eastern coast of Spain. The area's population was 321 361, of whom 60 079 (18.7%) were 60 or older, including 43 044 (13.4%) who were 65 or older. A descriptive study of the analyzed variables was done, with the mean and standard deviation being computed for quantitative variables, and the absolute and relative frequencies (percentages) being calculated for the qualitative variables. Results. Of the patients studied, 78% of them were 65 or older, with an average age of 73 years. They were predominantly women. Of the total group, 72% of them had chronic diseases, and 67% had at least one associated secondary diagnosis. There was an important problem of communication between the two principal levels of care, primary care and hospital care, which obviously had an impact on the patients and on the quality and effectiveness of their health care. Furthermore, it was found that HH finds its greatest utility with and is an effective tool for an adult or elderly population that has multiple chronic degenerative or terminal diseases. Conclusions. The results of this study highlight the need to create or strengthen channels and mechanisms for interinstitutional communication that will guarantee continuity of care. The ongoing, effective care of the health and well-being of elderly persons requires different levels of health interventions. This care should be comprehensive, adequate, integrated, of high quality, humanized, timely, and coordinated between the two principal levels of health care. In the final analysis, these factors will determine the quality of the health care for geriatric patients and the capacity to solve their health problems

La hospitalización domiciliaria: antecedentes, situación actual y perspectivas / Home hospitalization: background, current situation,and future prospects

Objetivo. Determinar las distintas variantes que ha tenido el concepto de la hospitalización domiciliaria a lo largo del tiempo, para así contribuir al debate sobre las circunstancias que inciden en la gestión sanitaria frente a futuros retos. Métodos. Se revisa la literatura sobre la atención domiciliaria como modalidad asistencial de salud mediante una exploración de las publicaciones indizadas en MEDLINE, LILACS y el Índice Médico Español durante el período de 1995­2000. Resultados. La hospitalización domiciliaria ha tenido un desarrollo desigual a lo largo del tiempo en diferentes países y son varios los modelos de este tipo de atención, cada uno con sus respectivas ventajas y desventajas. Conclusiones. Se definen algunos criterios y propuestas que podrían enmarcar una gestión domiciliaria innovadora, efectiva y de calidad. Se concluye que la atención domiciliaria podría contribuir a diseñar y establecer un modelo consensuado y armonioso de organización y financiación entre los niveles de atención primaria y hospitalaria

Objective. To establish the different forms that the concept of home care has taken over time as a modality for providing health care, so as to contribute to the debate on the circumstances affecting health care management in the face of future challenges. Methods. The literature is reviewed on home care as a method for delivering health care, by researching publications indexed during the period of 1995­2000 in three medical bibliographical databases: MEDLINE, LILACS (Latin American and Caribbean Health Sciences) and the Índice Médico Español (Spanish Medical Index). Results. Home hospitalization has developed differently over time in various countries, with an assortment of models for this type of care, each with its respective advantages and disadvantages. Conclusions. There are some criteria and proposals that could provide a framework for home care that is innovative, effective, and of high quality. Home care could help in the design and creation of a consensus on an organizational and financing model that fits in harmoniously between primary care and care in a hospital