Assuntos
Neoplasias Ovarianas/mortalidade , Teratoma/mortalidade , Adolescente , Adulto , Ciclofosfamida/administração & dosagem , Dactinomicina/administração & dosagem , Quimioterapia Combinada , Feminino , Humanos , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/cirurgia , Teratoma/tratamento farmacológico , Teratoma/cirurgia , Vincristina/administração & dosagemAssuntos
Neoplasias dos Genitais Femininos/patologia , Adenocarcinoma/patologia , Adenocarcinoma/cirurgia , Carcinoma/patologia , Carcinoma/cirurgia , Neoplasias das Tubas Uterinas/patologia , Neoplasias das Tubas Uterinas/cirurgia , Feminino , Neoplasias dos Genitais Femininos/cirurgia , Humanos , Laparotomia , Recidiva Local de Neoplasia/patologia , Neoplasias Ovarianas/patologia , Neoplasias Ovarianas/cirurgia , Neoplasias Uterinas/patologia , Neoplasias Uterinas/cirurgiaAssuntos
Adenocarcinoma/cirurgia , Carcinoma de Células Escamosas/cirurgia , Ovário/fisiologia , Neoplasias do Colo do Útero/cirurgia , Adenocarcinoma/radioterapia , Adolescente , Adulto , Carcinoma de Células Escamosas/radioterapia , Estrogênios/fisiologia , Estrogênios/efeitos da radiação , Feminino , Hormônio Foliculoestimulante/fisiologia , Hormônio Foliculoestimulante/efeitos da radiação , Humanos , Histerectomia , Hormônio Luteinizante/fisiologia , Hormônio Luteinizante/efeitos da radiação , Métodos , Ovário/efeitos da radiação , Ovário/cirurgia , Complicações Pós-Operatórias , Dosagem Radioterapêutica , Neoplasias do Colo do Útero/radioterapiaRESUMO
Thirty-nine patients with multifocal carcinoma in situ of the vulva were managed with en bloc removal of the involved skin and a split-thickness skin graft to the surgical defect. The characteristic presentations of this clinical entity are reported and options for the therapy are discussed. Thirty-nine percent of the patients developed a recurrence, but none of the recurrences was within the donated skin graft. No reports of dyspareunia or seriously altered sexual function were noted. The details of the surgical approach ae outlined and modifications of the original procedure are described.
Assuntos
Carcinoma in Situ/cirurgia , Neoplasias Vulvares/cirurgia , Adulto , Feminino , Humanos , Métodos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Transplante de Pele , Transplante AutólogoRESUMO
Immunotherapy with nonspecific immunopotentiators such as Corynebacterium parvum is under study in several areas of gynecologic oncology. The efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. This report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patients) and cervical (12 patients) cancer who were treated with intravenous C. parvum in addition to either chemotherapy (Alkeran) or pelvic radiotherapy. Monitoring of the immune response was accomplished by skin testing, T-lymphocyte rosettes, B-lymphocyte rosettes, simulation of lymphocytes with mitogens (PHA and Con-A) and total lymphocyte counts. No distinct improvement in these parameters could be demonstrated as a result of immunotherapy with C. parvum. These results and the value of immune monitoring as currently performed are discussed.
Assuntos
Imunidade Celular , Imunoterapia , Monitorização Fisiológica/métodos , Neoplasias Ovarianas/terapia , Propionibacterium acnes/imunologia , Neoplasias do Colo do Útero/terapia , Linfócitos B/imunologia , Feminino , Humanos , Contagem de Leucócitos , Ativação Linfocitária , Neoplasias Ovarianas/imunologia , Formação de Roseta , Testes Cutâneos , Linfócitos T/imunologia , Neoplasias do Colo do Útero/imunologiaRESUMO
Early invasive squamous cell carcinoma of the vulva has emerged as a controversial issue in recent literature. Reports illustrating metastatic disease in the inguinal lymph nodes have conflicted with other reports suggesting local treatment only. The morbidity produced by radical vulvectomy to both body image and sexual function make this issue worthy of serious consideration. This report deals with an alternate approach to this disease entity which attempts to preserve vulvar tissue without sacrificing curability where possible metastatic disease exists. The concept is proposed of utilizing the superficial inguinal nodes as sentinel nodes in the treatment planning. The results of 20 patients treated in this manner are presented.