[Sustainable job retention for people diagnosed with a cancer in a changing world of work]. / Maintien durable au travail des personnes diagnostiquées d'un cancer dans un monde du travail en mutation.

INTRODUCTION: The growing number of people diagnosed with a cancer of working age prompts us to explore the sustainability of their working conditions and avenues of intervention in their work situations to promote sustainable job retention in a context of work intensification. METHODS: Narrative review of the literature on people diagnosed with a cancer, their work situation, participation in the labour market, return to work (RTW) and sustainable employment. RESULTS: Transformations in the world of work are increasing the unpredictability and variability of work situations, making strategies for managing functional deficiencies after diagnosis of the disease more complex. Reinforcing socio-technical and organizational leeways (STOL), i.e. self-regulation capacities to cope with the demands of the work situation by deploying effective and healthy work strategies, implies optimizing the (external) resources available at the level of the work situation through ergonomic actions and/or improving individual (internal) resources through supportive care or rehabilitation and/or vocational training. DISCUSSION: Interventions to help people diagnosed with a cancer to stay at work in the long term must give primacy to the accommodation of the work situation and identify the ergonomic levers for improving their STOL.

An mtDNA perspective of French genetic variation.

BACKGROUND: The French has been insufficiently characterized so far for mitochondrial DNA (mtDNA) diversity. AIMS: The study aimed to enhance the information available for the French mtDNA pool and to explore the potential microgeographical differentiation of two French regions selected for their linguistic and historical idiosyncrasies. SUBJECTS AND METHODS: A total of 868 samples from 12 different locations in France were collected. They were sequenced for the hypervariable segment I (HVS-I) and typed for haplogroup defining markers from the coding region either by restriction fragment length polymorphism (RFLP) or by a new protocol based on the 5' nuclease allelic discrimination. The mtDNA gene pools of French Basques and Bretons were compared in terms of frequency and composition with relevant neighbouring populations. RESULTS: The French Basques' mtDNA pool shares some common features with that of the Spanish Basques, such as the high frequency of haplogroup H. However, the French Basques exhibit a number of distinct features, most notably expressed in the prevalence of haplogroups linked with the Neolithic diffusion in Europe. In Brittany, Finistère shows closer affinities with Britain and Scandinavia than the two other departments of Brittany. CONCLUSION: The mtDNA haplogroup composition of the French does not differ significantly from the surrounding European genetic landscape. At a finer grain, microgeographical differentiation can be revealed, as shown for the French Basque country and for Brittany.