On-the-job and off-the-job embeddedness differentially influence relationships between informal job search and turnover.

Whereas informal job search (i.e., using personal contacts for job search) is positively associated with the receipt of job offers, research has yet to consider the extent to which informal job search translates into current employees' turnover decisions or to investigate factors that may restrain (or facilitate) the translation of informal job search into turnover decisions. In this study, we propose that on-the-job and off-the-job embeddedness play distinct roles in strengthening or weakening the positive relationship between informal job search and turnover intentions and behavior. We assert that on-the-job embeddedness reduces the likelihood that informal job search translates into turnover decisions, whereas off-the-job embeddedness strengthens the positive association between informal job search and turnover decisions. We tested these hypotheses across two samples of employed nurses. Although results were mixed, we found evidence that on-the-job embeddedness dampened the positive relationships of informal job search with turnover intentions and behaviors, whereas off-the-job embeddedness facilitated the positive relationships between informal job search and turnover decisions. Taken together, findings suggest that on-the-job and off-the-job embeddedness influence informal job search processes differently. We discuss the implications of these findings for how organizations manage employees' informal job search activities as well as how researchers approach the study of job embeddedness. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Formal Total Synthesis of Echinopines A and B via Cr(0)-Promoted [6π + 2π] Cycloaddition.

A concise formal synthesis of echinopines A and B is reported. The key [5.5.7] tricyclic intermediate, which has been previously used for the synthesis of echinopine A and B, was assembled using Cr(0)-promoted photochemical [6π + 2π] cycloaddition followed by a radical cyclization step.

Bullet embolus to the right ventricle following shotgun wound to the leg.

Bullet embolism to the heart is a rare complication of gunshot trauma to the body and if not identified can have a severe impact on a patient's morbidity and mortality. This paper presents the case of a patient who sustained a shotgun wound to the leg 10 years prior to presenting with shortness of breath and localised chest pain. Routine chest radiograph for possible chest infection was reported normal apart from a small metallic artefact overlying the left side of the heart, which had the same appearance as the pellets from the gunshot wound in the leg. Following referral to our cardiothoracic surgeons, further investigations confirmed the presence of a pellet within the patient's right ventricle, which had embolised from the original injury site. The case was discussed globally to decide on the best management plan. To date, the patient has been successfully managed conservatively, with regular follow-up.

Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F.

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.

Stereoselective synthesis of the C1-C11 and C12-C34 fragments of mycalolide A.

A convergent synthesis of the C1-C11 and C12-C34 fragments of mycalolide A is described. Synthetic highlights include a highly E-selective cross-metathesis between a vinyl-functionalized bis-oxazole unit and a polypropionate side chain to introduce the C19-C20 double bond and an enzymatic desymmetrization of a meso-diol in addition to five stereoselective allylations/crotylations to control the 11 stereogenic centers present in the natural product.

Enantioselective organocatalytic conjugate reduction of beta-azole-containing alpha,beta-unsaturated aldehydes.

Beta-azole-containing alpha,beta-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7-C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.

Chromium(0)-promoted [6pi + 2pi] cycloadditions of allenes with cycloheptatriene.

Photoinitiated [6pi + 2pi] cycloadditions of allenes with (eta(6)-cycloheptatriene)tricarbonylchromium(0) (1) are described. An example of asymmetric induction obtained by reaction of 1 with a chiral 1,3-disubstituted allene is also reported.

Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis.

A ruthenium-based catalyzed olefin cross-methathesis reaction involving 2- and 4-vinyl-functionalized oxazoles was developed. A wide range of olefinic partners was coupled in good to excellent yields and high stereoselectivities under mild conditions. This methodology offers new opportunities for the synthesis of a plethora of biologically active natural products.

Total synthesis of (+/-) -phenserine via [4+1] cyclization of a bis(alkylthio)carbene and an indole isocyanate.

[structure: see text]. A total synthesis of acetylcholine blocking agent, phenserine, has been achieved by employing a [4+1] cyclization between an appropriately substituted indole isocyanate and a bis(alkylthio)carbene.

New entry into beta-lactams via reaction of dimethoxycarbene with isocyanates.

[reaction: see text] Highly substituted beta-lactams have been isolated as the major product of the reaction of dimethoxycarbene with selected isocyanates. This reaction offers the potential for rapid access into a variety of highly functionalized species.

Chromium(0)-promoted multicomponent cycloaddition of tethered diynes with cyclic trienes: application to the total synthesis of 9-epi-pentalenic acid.

An efficient protecting group controlled regioselective chromium(0)-mediated three-component higher order cycloaddition of tethered diynes with cyclic trienes that generates five rings and six stereogenic centers in one step is described. Following a sequence of reactions featuring a chemoselective Baeyer-Villiger rearrangement and a regioselective cyclopropane hydrogenolysis, the total synthesis of 9-epi-pentalenic acid was achieved.

Preparation of highly substituted 4-aminopyridones via the reaction of 2-methylene dihydrobenzimidazole with vinyl isocyanates.

[reaction: see text] The rapid construction of highly substituted 4-aminopyridones was achieved employing an efficient cyclization between various vinyl isocyanates and 2-methylene dihydrobenzimidazole.

Synthesis of highly substituted cyclopentenones via the [4 + 1] cycloaddition of nucleophilic carbenes and vinyl ketenes.

[reaction: see text] Vinyl ketenes have been shown to undergo [4 + 1] cycloaddition with a variety of nucleophilic carbenes to deliver highly substituted cyclopentenones as products.

[4 + 1] cycloaddition of N-heterocyclic carbenes with vinyl isocyanates.

[reaction: see text] N-Heterocyclic carbenes have been found to undergo [4 + 1] cycloaddition with various vinyl isocyanates to afford functionalized hydroindolone products.

Solid-phase C-C and C-O bond forming reactions using 'traceless' pi-arene-chromium linkers.

The scope of solid-phase reactions utilizing a 'traceless' pi-arene-chromium linker has been expanded to include the addition of organo-lithium reagents to a supported ester group, generation and alkylation of an enolate anion, and substitution via the Mitsunobu reaction. Immobilization of ortho-disubstituted polyfunctionalized arene chromium dicarbonyl species onto the solid support and subsequent, selective transformation is also reported.

Synthetic studies on the ingenane diterpenes. An improved entry into a trans-intrabridgehead system.

[reaction: see text] The efficient construction of an ingenol intermediate exhibiting "insideminus signoutside" intrabridgehead stereochemistry is reported. The sequence features the net conversion of a cis-intrabridgehead compound into a highly strained trans-species via palladium-mediated isomerization of an allylic epoxide followed by a low-temperature alkoxide-accelerated 1,5-hydrogen migration.