RESUMO
Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.
Assuntos
Anti-Infecciosos/efeitos adversos , Dapsona/efeitos adversos , Síndrome de Hipersensibilidade a Medicamentos/etiologia , Glucosefosfato Desidrogenase/sangue , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Diagnóstico Diferencial , Feminino , Deficiência de Glucosefosfato Desidrogenase , Humanos , Pessoa de Meia-Idade , Pneumonia/induzido quimicamente , Vasculite/tratamento farmacológicoAssuntos
Betametasona/uso terapêutico , Fármacos Dermatológicos/uso terapêutico , Eritema/tratamento farmacológico , Dermatopatias/tratamento farmacológico , Queimadura Solar/tratamento farmacológico , Protetores Solares/uso terapêutico , Vitamina E/uso terapêutico , Adulto , Eritema/prevenção & controle , Humanos , Neutrófilos/efeitos dos fármacos , Raios UltravioletaRESUMO
The hallmark of photoaged skin is solar elastosis, which is probably an end product of elastic fiber degradation. Exposure of human skin to a certain threshold of UV, infrared radiation (IR), and heat leads to an influx of neutrophils. These neutrophils are packed with potent proteolytic enzymes capable of degrading collagen and, particularly, elastic fibers. Neutrophil-derived proteolytic enzymes are held responsible for the extracellular matrix (ECM) damage observed in several non-dermatological conditions. Furthermore, neutrophil elastase, a major product of neutrophils, is strongly associated with solar elastosis in mice. Taken together with our data that show in vivo proteolytic activity of neutrophil-derived elastase and matrix metalloproteinases (MMPs) in UV-exposed skin, we have hypothesized earlier that neutrophils are major contributors to the photoaging process. Although several groups have shown that MMPs are also induced in skin exposed to relatively low doses of UV, IR, and heat, clinical data indicate that high(er) doses of UV, IR, and heat are necessary to induce photoaging or photoaging-like pathology in the skin. Therefore, we propose that MMPs generated by suberythemogenic doses of UV and low doses of IR/heat are involved in cellular processes other than ECM degradation.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 67-72; doi:10.1038/jidsymp.2009.15.
Assuntos
Neutrófilos/enzimologia , Neutrófilos/efeitos da radiação , Envelhecimento da Pele/patologia , Envelhecimento da Pele/fisiologia , Animais , Tecido Elástico/enzimologia , Tecido Elástico/patologia , Tecido Elástico/efeitos da radiação , Matriz Extracelular/enzimologia , Matriz Extracelular/efeitos da radiação , Fibroblastos/enzimologia , Fibroblastos/efeitos da radiação , Temperatura Alta/efeitos adversos , Humanos , Raios Infravermelhos/efeitos adversos , Queratinócitos/enzimologia , Queratinócitos/efeitos da radiação , Metaloproteinases da Matriz/metabolismo , Camundongos , Modelos Biológicos , Neutrófilos/patologia , Raios Ultravioleta/efeitos adversosRESUMO
UV-induced skin damage is the result of a complex cascade of events. Many studies have focused on the skin effects induced by UV-B or UV-A separately. Recently a UV-source that emits UV-B and UV-A together in a ratio comparable to daily sunlight has been introduced: i.e. solar simulated radiation (SSR). By exposing human skin type I-III to erythematogenic doses of UV (> or =1 MED) emitted by a SSR source we have noticed that: (a) neutrophils are initially the main infiltrating cell type in the dermis and (b) these infiltrating cells are the a key source of in vivo enzymatically [corrected] active enzymes such as elastase, [corrected] matrix metallo proteinases-1 and -9 (MMPs-1 and -9). These enzymes are relevant to the process of photoaging, as they break down the extracellular matrix. Keratinocytes and fibroblasts also produce matrix degrading enzymes, but to a lesser extent. Our results indicate a primary role for infiltrating neutrophils in the initial steps of photoaging. This is further supported by the observation that after exposure of skin type VI to physical doses of SSR, equivalent to those used for skin types I-III, no neutrophils and neutrophil-derived enzymatic activity were observed, explaining why skin type VI is [corrected] less susceptible to photoaging than skin types [corrected] I-III. Statement: Although most of the data, referred to, have been published, the current perspective in which they are put together is completely novel and has not been published elsewhere.
Assuntos
Neutrófilos/efeitos da radiação , Envelhecimento da Pele/efeitos da radiação , Pele/fisiopatologia , Pele/efeitos da radiação , Raios Ultravioleta/efeitos adversos , Humanos , Metaloproteinases da Matriz/metabolismo , Metaloproteinases da Matriz/efeitos da radiação , Neutrófilos/enzimologia , Neutrófilos/imunologia , Elastase Pancreática/metabolismo , Elastase Pancreática/efeitos da radiação , Envelhecimento da Pele/imunologiaRESUMO
Black skin is more resistant to the deleterious effects of ultraviolet radiation than white skin. A higher melanin content and a different melanosomal dispersion pattern in the epidermis are thought to be responsible for this. Our purpose was to compare skin responses in black and white skin following exposure to solar-simulating radiation (SSR) to further investigate the photoprotective properties of black skin. Six volunteers of skin phototype I-III (white) were exposed to (doses measured directly with a Waldmann UV detector device) 12,000-18,000 mJ per cm2 (2 MED) of SSR and compared with six volunteers of skin phototype VI (black) exposed to 18,000 mJ per cm2 (<1 MED) of SSR. The presence and distribution of skin pigment, DNA photodamage, infiltrating neutrophils, photoaging associated proteolytic enzymes, keratinocyte activation, and the source of interleukin 10 (IL-10) in skin biopsies taken before and after exposure were studied. In all white skinned subjects, 12,000-18,000 mJ per cm2 of SSR induced DNA damage in epidermal and dermal cells, an influx of neutrophils, active proteolytic enzymes, and diffuse keratinocyte activation. Additionally, in three of the white skinned volunteers IL-10 positive neutrophils were found to infiltrate the epidermis. Except for DNA damage in the supra basal epidermis, none of these changes was found in black skinned subjects. Increased skin pigmentation appears to be primarily responsible for the observed differences in skin responses. Our data could provide an explanation as to why black skin is less susceptible to sunburn, photoaging, and skin carcinogenesis.