RESUMO
OBJECTIVE: The objective of this study was to investigate whether histamine H4 receptor (H4 R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. METHODS: Bilateral EP was induced for 2 weeks in anaesthetized male rats. The effect of systemic and local administration of H4 R antagonists (JNJ7777120, JNJ10191584) on histopathology and functionality of SMG, bone loss and gingival inflammation was evaluated. RESULTS: The subcutaneous administration of JNJ7777120 prevented periodontitis-induced SMG histological injury, reducing vacuolization and apoptosis and additionally reversed the increased prostaglandin E2 (PGE2) levels in SMG while it partially reversed the methacholine-induced salivation reduction produced by periodontitis. JNJ7777120 attenuated bone loss and the increased PGE2 levels and inflammatory infiltration in gingival tissue of rats with periodontitis. Finally, local administration of JNJ7777120 and JNJ10191584 was also beneficial for improving periodontal parameters. CONCLUSIONS: H4 receptor antagonists are able to ameliorate periodontitis-induced injury on SMG, gingival tissue and bone structure, suggesting that pharmacological targeting of H4 R could be an attractive strategy to improve periodontal health.
Assuntos
Antagonistas dos Receptores Histamínicos/farmacologia , Indóis/farmacologia , Doenças Periodontais/prevenção & controle , Piperazinas/farmacologia , Receptores Acoplados a Proteínas G/antagonistas & inibidores , Perda do Osso Alveolar/tratamento farmacológico , Perda do Osso Alveolar/patologia , Processo Alveolar/efeitos dos fármacos , Processo Alveolar/patologia , Animais , Apoptose/efeitos dos fármacos , Modelos Animais de Doenças , Gengiva/química , Gengiva/efeitos dos fármacos , Gengiva/patologia , Masculino , Cloreto de Metacolina/farmacologia , Terapia de Alvo Molecular , Doenças Periodontais/patologia , Periodontite/tratamento farmacológico , Periodontite/patologia , Ratos , Ratos Sprague-Dawley , Receptores Histamínicos , Receptores Histamínicos H4 , Glândula Submandibular/efeitos dos fármacos , Glândula Submandibular/patologiaRESUMO
Se analizan los aspectos clínicos y terapéuticos de 44 casos de estenosis hipertrófica congénita del píloro.El estudio demostró predominio del sexo masculino y su máxima presentación entre la segunda y tercera semana de edad postnatal. Los síntomas y signos más frecuentes fueron: vómitos en proyectil, palpación de la oliva pilórica y ondas peristálticas visibles. Todos los pacientes fueron tratados quirúrgicamente, siendo las complicaciones más frecuentes perforación duodenal y pilórica. No hubo mortalidad.
