Neoadjuvant Imatinib in Gastrointestinal Stromal Tumors (GIST): The First Analysis of a Mexican Population.

Introduction Gastrointestinal stromal tumors (GISTs) are neoplasms originating from the interstitial cells of Cajal, pacemaker cells responsible for intestinal motility. Patients with locally advanced GISTs and those with borderline resections due to the proximity of vital anatomical structures, which could result in unacceptable post-surgical morbidity, require special therapeutic consideration. Imatinib, a tyrosine kinase inhibitor, has demonstrated significant success in the non-surgical management of metastatic GIST, and its favorable impact on overall survival in the adjuvant setting makes it logical to speculate on the benefit it could provide as a neoadjuvant medication in patients with locally advanced disease. Methods Patients aged 18-90 years with a diagnosis of GIST confirmed by immunohistochemistry (CD117 positivity) who were treated at the Oncology Hospital of Centro Médico Nacional Siglo XXI in Mexico City from January 2012 to December 2016 were included in the study. It is a retrospective study with a duration of four years. Clinical data were collected from the medical records, which included sex, age, tumor location, initial resectability, reason for unresectability, initial tumor size, and mitotic rate. In the case of unresectable disease, patients who were evaluated by medical oncology and who had received treatment with 400 mg of imatinib daily were evaluated. Results A total of 312 patients diagnosed with GIST were analyzed. One hundred thirty-one were men (42%) with a mean age of 57 years, and 181 were women (58%) with a mean age of 59 years. The most frequent anatomical location was the stomach (n=185, 59.2%). At the time of diagnosis, 210 patients (67.3%) presented with resectable disease, while n=102 patients (32.7%) had unresectable disease. A total of 102 patients with unresectable disease received therapy with 400 mg of imatinib per day. Sixteen patients (15.7%) presented a reduction in tumor dimensions and underwent surgery. Conclusion The study highlights the importance of complete surgical resection and the potential benefit of neoadjuvant imatinib therapy in converting unresectable to resectable disease. The results suggest that imatinib can be effective in converting unresectable GISTs to resectable ones, allowing for a complete resection to be performed and obtaining an R0 resection in 93.7% of these cases.

Where has the circle taken us? A conversation on sexual health promotion for sex-dissident populations. / Para onde a roda nos levou? Uma conversa sobre promoção da saúde sexual para populações sexo-dissidentes.

This work discusses the health promotion challenges of men who have sex with men (MSM) through the use of data from a conversation circle with people from institutions that provide services to MSM in the Metropolitan Region of Recife. The results allow for the identification of the following challenges for health promotion work, not only for MSM but also for sex dissidents: difficulties with the use of identity categories, stigmatization for providing them with sexual health care, structural racism, the deprivation of liberty, extreme poverty, and literacy.

O texto discute os desafios para promoção da saúde de homens que fazem sexo com homens (HSHs) por meio de dados oriundos de uma roda de conversa, com pessoas de instituições que prestam serviços para HSHs na Região Metropolitana do Recife. Os resultados permitiram identificar desafios para o trabalho de promoção à saude, não só para HSHs, mas para pessoas sexo-dissidentes: dificuldades com o uso das categorias de identidade; estigmatização por prestar-lhes cuidado em saúde sexual; racismo estrutural; contexto de privação de liberdade; extrema pobreza; letramento.

Prognostic Factors of Survival in Patients With Gastric Cancer Under 45 Years Old Treated With Surgery in a Single Center in Mexico City.

Introduction Gastric cancer is a significant major global health concern, particularly prevalent in Asia. In recent years, a large number of new cases have been diagnosed worldwide, leading to a substantial number of deaths. The disease tends to present more aggressively in these cases, leading to debates about the prognosis and survival outcomes. Nonetheless, research has shown that survival rates improve significantly when the tumor is completely surgically resected. Materials and methods This retrospective study included patients between 16 and 45 years old, diagnosed with gastric cancer, with the support of the pathology department, who underwent surgery in the upper GI service, in the period from January 2006 to December 2012. Data collected encompassed variables such as gender, age, tumor size, type of surgery, overall survival, disease-free period, type and histological degree of the tumor, clinical stage of the cancer, and R0 resection (curative resection). All patients with a confirmed diagnosis of gastric cancer were included and treated with surgery and D1 limited dissection or extended D2 dissection. Patients who have received chemotherapy prior to surgical treatment and those who have been surgically treated outside the XXI Century National Medical Center were excluded. Results A total of 104 patients were included; the predominant histological type was diffuse adenocarcinoma accounting for 79.8% and 81.7% of the cases were histological grade 3. The most common clinical stage was IIIA in 41.3% of the cases. In 53.8% of the cases, we obtained an R0 resection. D2 lymphadenectomy was performed in 53.8% of the cases, with an overall survival rate of 82.69%. Significant prognostic factors for survival included T4 depth with an increase in risk for mortality (OR: 25.93; 95% CI: 6.41-53.54; p=0.001), lymph node status (OR: 14.76; 95% CI: 4.6-46.83; p<0.001), and size greater than 5 cm (OR: 1.8; 95% CI: 0.61-6.35; p<0.001). Conclusions Gastric cancer is more common in adults aged above 60 years old, but the incidence in young adults under 45 years old has been increasing. Although young gastric cancer patients present with more aggressive tumor behavior, these patients can have similar or even better overall survival compared to older patients, being 35% in some cases, especially in the resectable setting. Further research is still needed to fully characterize the unique biology and optimal management of gastric cancer in young adults.

Evaluation of the Antioxidant and Anti-Inflammatory Activities and Acute Toxicity of Caco Seed (Chrysobalanus icaco L.) in Murine Models.

Chysobalanus icaco L. (C. icaco) is a plant that is native to tropical America and Africa. It is also found in the southeast region of Mexico, where it is used as food and to treat certain diseases. This study aimed to carry out a phytochemical analysis of an aqueous extract of C. icaco seed (AECS), including its total phenol content (TPC), total flavonoid content (TFC), and condensed tannins (CT). It also aimed to examine the antioxidant and metal-ion-reducing potential of the AECS in vitro, as well as its toxicity and anti-inflammatory effect in mice. Antioxidant and metal-ion-reducing potential was examined by inhibiting DPPH, ABTS, and FRAP. The acute toxicity test involved a single administration of different doses of the AECS (0.5, 1, and 2 g/kg body weight). Finally, a single administration at doses of 150, 300, and 600 mg/kg of the AECS was used in the carrageenan-induced model of subplantar acute edema. The results showed that the AECS contained 124.14 ± 0.32 mg GAE, 1.65 ± 0.02 mg EQ, and 0.910 ± 0.01 mg of catechin equivalents/g dried extract (mg EC/g de extract) for TPC, TFC and CT, respectively. In the antioxidant potential assays, the values of the median inhibition concentration (IC50) of the AECS were determined with DPPH (0.050 mg/mL), ABTS (0.074 mg/mL), and FRAP (0.49 mg/mL). Acute toxicity testing of the AECS revealed no lethality, with a median lethal dose (LD50) value of >2 g/kg by the intragastric route. Finally, for inhibition of acute edema, the AECS decreased inflammation by 55%, similar to indomethacin (59%, p > 0.05). These results demonstrated that C. icaco seed could be considered a source of bioactive molecules for therapeutic purposes due to its antioxidant potential and anti-inflammatory activity derived from TPC, with no lethal effect from a single intragastric administration in mice.

Strength characteristics in faster change of direction basketball players: A comparison across cutting angles.

Change of directions (COD) involves multidirectional and complex actions, with performance influenced by multiple factors. As lower limb strength is one of the most determinant of COD performance, the present study aimed to (a) explore the differences in strength outcomes across different lower limb muscle actions between faster and slower basketball players in COD actions at different angles and (b) analyse the relationship between isometric, concentric and eccentric strength outcomes and COD performance at different cutting angles. Twenty-five basketball players (44% female) completed a battery of tests, encompassing isokinetic and isometric squat strength assessments, along with COD tests at 45°, 90° and 180°. Players were categorised as 'low-performance' and 'high-performance' groups based on execution time in COD, facilitating a comparison between performance groups. Results indicated that concentric strength showed the greatest differences between performance groups at 45° COD (effect size ≥ 0.813; p ≤ 0.034). Isometric and eccentric strength demonstrated a moderate-to-large relationship with 90° COD performance (Rho ≥ 0.394; p ≤ 0.045), and all muscle actions exhibited a large relationship with 180° COD (Rho ≥ 0.445; p ≤ 0.030). Moreover, the fastest players showed higher levels of concentric strength relative to eccentric strength, regardless of the cutting angle. These findings hold practical applications, suggesting that basketball coaches should train a specific kind of muscle action depending on the individual players' COD demands, focusing on improving the rapid eccentric force application while striving to reduce the eccentric/concentric ratio.

Exploring the impact of encapsulation on the stability and bioactivity of peptides extracted from botanical sources: trends and opportunities.

Bioactive peptides derived from plant sources have gained significant attention for their potential use in preventing and treating chronic degenerative diseases. However, the efficacy of these peptides depends on their bioaccessibility, bioavailability, and stability. Encapsulation is a promising strategy for improving the therapeutic use of these compounds. It enhances their stability, prolongs their shelf life, protects them from degradation during digestion, and enables better release control by improving their bioaccessibility and bioavailability. This review aims to analyze the impact of various factors related to peptide encapsulation on their stability and release to enhance their biological activity. To achieve this, it is necessary to determine the composition and physicochemical properties of the capsule, which are influenced by the wall materials, encapsulation technique, and operating conditions. Furthermore, for peptide encapsulation, their charge, size, and hydrophobicity must be considered. Recent research has focused on the advancement of novel encapsulation methodologies that permit the formation of uniform capsules in terms of size and shape. In addition, it explores novel wall materials, including polysaccharides derived from unconventional sources, that allow the precise regulation of the rate at which peptides are released into the intestine.

Test-Retest Reliability of an Isometric and Isometric/Vibratory Muscular Strength Protocol with Functional Electro-Mechanical Dynamometry.

The purpose of the study was to analyze the test-retest reliability of an isometric and isometric/vibratory muscular strength protocol in the bilateral seated bench press (BSBP), bilateral seated rowing (BSR), unilateral seated right knee extension (USKER), and left knee extension (USKEL) tests controlled using functional electromechanical dynamometry (FEMD) in healthy young adults. A repeated measures design was used to determine the reliability of a muscular strength protocol in isometric and isometric vibration modes with FEMD. No significant differences were found in test-retest analysis (p > 0.05; ES < 0.20); and high reliability (CV = 4.65-5.02%; ICC = 0.99-0.98) was found for BSBP measures, and acceptable reliability (CV = 3.71-9.61%; ICC = 0.98-0.95) was found for BSR, USKER, and USKEL. Furthermore, the coefficients between the two measures were strong (r = 0.963-0.839) and highly significant (p = 0.001) for maximal strength in the isometric and maximal isometric/vibratory assessment of muscle strength in all muscle strength tests. This study demonstrates that isometric and maximal isometric/vibratory strength in the BSBP, BSR, USKER, and USKEL tests can be measured with high reliability and reproducibility using the FEMD.

Exploring lower limb muscle activity and performance variations during instrumented Sit-to-Stand-to-Sit in sedentary individuals: Influence of limb dominance and testing modalities.

PURPOSE: to explore lower limb muscle activity concerning limb dominance, as well as variations in force and power during the standing up and sitting down phases of the instrumented sit-to-stand-to-sit test in sedentary individuals, across isokinetic and isotonic modalities. METHODS: 33 sedentary individuals underwent testing using a functional electromechanical dynamometer in both isokinetic and isotonic modes, accompanied by surface electromyography. RESULTS: In the isokinetic mode, the non-dominant gastrocnemius medialis and vastus medialis exhibited significantly (p < 0.05) higher muscle activity values during the standing up and sitting down phase compared to dominant counterparts. In the isotonic mode standing up phase, significant differences in muscle activity were noted for non-dominant gastrocnemius medialis, vastus medialis, and biceps femoris compared to their dominant counterparts. The sitting down phase in isotonic mode showed higher muscle activity for non-dominant vastus medialis compared to dominant vastus medialis. Regard to performance outcomes, significantly lower (p < 0.0001) values were observed for standing up (12.7 ± 5.1 N/kg) compared to sitting down (15.9 ± 6.1 N/kg) peak force, as well as for standing up (18.7 ± 7.8 W/kg) compared to sitting down (25.9 ± 9.7 W/kg) peak power in isokinetic mode. In isotonic mode, lower values were found for sitting down (6.5 (6.3-7.1) N/kg) compared to standing up (7.8 (7.3-8.9) N/kg) peak force and for sitting down (18.5 (13.2-21.7) W/kg) compared to standing up (33.7 (22.8-41.6) W/kg) peak power. CONCLUSIONS: Limb dominance influences lower-limb muscle activity during the instrumented sit-to-stand-to-sit test, and the choice of testing mode (isokinetic or isotonic) affects muscle engagement and performance outcomes.

Reliability of Dynamic Shoulder Strength Test Battery Using Multi-Joint Isokinetic Device.

This study aimed to determine the absolute and relative reliability of concentric and eccentric flexion, extension, horizontal abduction, and adduction movements of the shoulder using a functional electromechanical dynamometer (FEMD). Forty-three active male university students (23.51 ± 4.72 years) were examined for concentric and eccentric strength of shoulder flexion, extension, horizontal abduction, and horizontal adduction with an isokinetic test at 0.80 m·s-1. Relative reliability was determined by intraclass correlation coefficients (ICCs) with 95% confidence intervals. Absolute reliability was quantified by the standard error of measurement (SEM) and coefficient of variation (CV). Reliability was very high to extremely high for all movements on concentric and eccentric strength measurements (ICC: 0.76-0.94, SEM: 0.63-6.57%, CV: 9.40-19.63%). The results of this study provide compelling evidence for the absolute and relative reliability of concentric and eccentric flexion, extension, horizontal abduction, and horizontal adduction shoulder isokinetic strength tests in asymptomatic adults. The mean concentric force was the most reliable strength value for all tests.

Relationship between natural muscle oscillation frequency and lower limb muscle performance during instrumented sit-to-stand and stand-to-sit movements on a novel device in sedentary subjects.

BACKGROUND: Despite the significance of muscle oscillation frequency, previous research has not established a correlation with muscle performance due to the challenges of applying resistance without altering natural motion during functional tests. RESEARCH QUESTION: What is the correlation between muscle oscillation frequency and lower limb muscle strength, power, and work during an instrumented sit-to-stand and stand-to- sit (iSTS-TS) task among sedentary subjects? METHODS: In a cross-sectional study, the oscillation frequency of the gastrocnemius medialis (GM), biceps femoralis (BF), and vastus medialis (VM) muscles in both the dominant (D) and non-dominant (ND) legs was assessed with a handheld myotonometer in 34 sedentary individuals before performing the iSTS-TS task. RESULTS: In the isokinetic mode, no significant correlations were found. In the isotonic mode, the BF muscle oscillation frequency in the D and ND legs exhibited significant positive correlations with peak force, peak power, and work during sitting down, as well as peak power and work during standing up. Positive correlations were observed in both legs between the GM oscillation frequency and sitting down peak force and work. Additionally, significant positive correlation was found with standing up work in the D leg. Muscle oscillation frequency of the VM exhibited a positive correlation with sitting down peak force in the ND leg. SIGNIFICANCE: Due to a greater number of correlations found, it is advisable to use the isotonic mode when assessing muscle oscillation frequency in relation to muscle performance during functional iSTS-TS tasks in sedentary subjects.

Effects of different lower limb strengthening protocols on muscle activity, strength and power in sedentary and physically inactive subjects: a systematic review / Efectos de diferentes protocolos de fortalecimiento de miembro inferior sobre la fuerza, potencia y actividad muscular en sujetos sedentarios y físicamente inactivos: una revisión sistemática

The purpose of this systematic review was: a) to determine the quality of evidence from studies assessing the effects of different lower limb strengthening protocols on muscle activity, strength, and power in sedentary and/or physically inactive subjects; and b) to determine the effectiveness of lower extremity strengthening protocols on muscle activity, strength, and power in sedentary and/or physically inactive subjects. Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statements were followed using keywords associated with strength training, lower limb, sedentary, and physical inactivity. Four databases were used: Medline via PubMed, Web of Science, Scopus and SPORTDiscus. Methodological quality was assessed using the PEDro scale. A total of 164 articles were retrieved, six included in this review. Four studies were classified as fair methodological quality, and two were considered of good methodological quality. Due to the heterogeneity in methodological aspects and the limited number of articles including the variables under study, it was not possible to establish a measure of effectiveness of lower limb strengthening protocols on muscle activity, strength, or power. In conclusion, strength training in the lower limb seems to improve the levels of strength, power, and muscular activity in sedentary subjects. However, due to the limited number of articles, methodological variability, and training methods used, it is necessary to conduct new studies that control these variables.(AU)

El propósito de esta revisión sistemática fue: a) determinar la calidad de la evidencia de los estudios que evaluaron los efectos de diferentesprotocolos de fortalecimiento de miembros inferiores sobre la actividad, la fuerza y la potencia muscular en sujetos sedentarios y/o físicamenteinactivos; y b) determinar la efectividad de los protocolos de fortalecimiento sobre la actividad, fuerza y potencia muscular de miembros infe-riores en sujetos sedentarios y/o físicamente inactivos. Se siguieron los criterios PRISMA (Preferred Reporting Items for Systematic Review andMeta-Analyse) utilizando palabras clave asociadas con el entrenamiento de fuerza, extremidades inferiores, sedentarismo e inactividad física. Serevisaron cuatro bases de datos: Medline vía PubMed, Web of Science, Scopus y SPORTDiscus. La calidad metodológica se evaluó mediante laescala PEDro. Se recuperaron 164 artículos en total, seis incluidos en esta revisión. Cuatro estudios se clasificaron como de calidad metodológicaregular y dos se consideraron de buena calidad metodológica.Debido a la heterogeneidad en los aspectos metodológicos y al escaso número de artículos que incluyeron las variables en estudio, no fue posibleestablecer una medida de efectividad de los protocolos de fortalecimiento de miembros inferiores sobre la actividad, la fuerza o la potenciamuscular. En conclusión, el entrenamiento de fuerza en el miembro inferior parece mejorar los niveles de fuerza, potencia y actividad muscular ensujetos sedentarios. No obstante, debido al número limitado de artículos, la variabilidad metodológica y los métodos de entrenamiento utilizados,es necesario realizar nuevos estudios que controlen estas variables.(AU)

Physical properties of zein-alginate-glycerol edible films and their application in the preservation of chili peppers (Capsicum annuum L.).

Edible films elaborated from macromolecules, like carbohydrates, proteins, and lipids, must protect and maintain the integrity of foods during their handling, storage, and transportation. In this work, the effect of the concentration of zein (1-2% w/v), sodium alginate (1.5-2% w/v), and glycerol (2-4% w/v) on edible films physicochemical properties was evaluated. The Zein-Alginate-Glycerol interaction was evidenced by the FTIR analysis, the high permeability to water vapor and contact angles less than 90° of the polymer matrices formed. The film made with 2% zein, 1.5% sodium alginate and 4% glycerol preserved the quality of the chili pepper during 15 days of storage at 20 °C, the edible films allowed 3 more days of shelf life for weight loss and 10 more days for firmness. Edible films could be used in chili peppers that are destined for industrial processing, and before use, remove the film with a simple wash. Supplementary Information: The online version contains supplementary material available at 10.1007/s10068-023-01393-z.

Influence of trunk rotator strength on rotational medicine ball throwing performance.

BACKGROUND: The strength of the trunk musculature plays an essential role in performance. The aims of this study were to analyze the relationship between the strength of the trunk rotation muscles with rotational medicine ball throwing velocity and distance, to study differences between sex in rotational medicine ball throwing and to compare the asymmetries of trunk rotational strength and rotational medicine ball throwing. METHODS: Thirty physically active college students participated on the study. Horizontal and low cable woodchop exercises were assessed with a functional electromechanical dynamometer and throwing was measured with a radar and a measuring tape. A Pearson's correlation coefficient was calculated for the relation between trunk rotational strength and rotational medicine ball throwing. Independent samples t-test was performed to determine the differences between sex in rotational medicine ball throwing and a paired samples t-test was performed to study the asymmetries. RESULTS: Large and very large correlations were obtained between trunk rotational strength and rotational medicine ball throwing (r=0.68-0.79). Significant differences and a large effect size were found between males and females for all throwing velocity and throwing distance variables (P<0.05; ES>0.90) and asymmetries in performance of mean velocity throwing (P=0.003; ES=-0.60) and peak velocity throwing (P=0.025; ES=-0.43). No significant differences were found between dominant and non-dominant side in any of the trunk rotator strength assessment conditions (P>0.05). CONCLUSIONS: There is a large or very large correlation between the STRM and the RMBT in all its modalities. Differences in strength were found between sexes, with no significant differences between dominant and non-dominant sides.

Does vaginal surgery for correction of pelvic organ prolapse improve urinary function? A prospective cohort study.

INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) is caused by an imbalance in the stability of the pelvic organs, resulting in loss of support. The most common types of POP, anterior and apical, are associated with lower urinary tract symptoms (LUTS) such as bladder outlet obstruction and detrusor overactivity (DO). Vaginal surgery may improve LUTS and overall urinary symptoms. We assessed urodynamic (UD) parameters and urinary symptoms before and after vaginal surgery for POP correction. METHODS: A prospective cohort of 59 women with symptomatic anterior and/or apical POP associated with urinary symptoms and with indications for vaginal surgery were included. POP surgeries included anterior colporrhaphy and vaginal hysterectomy with culdoplasty (VH) and with/without concomitant posterior colporrhaphy and mid-urethral sling (MUS). All participants underwent UD evaluation and answered urinary symptom questionnaires pre- and 3 months post-surgery. RESULTS: Anterior colporrhaphy was performed in all patients: 45.7% with associated VH and 54.2% with concomitant MUS. Preoperative ICIQ-OAB score >8 points was significantly associated with DO (p<0.02) and decreased after surgery (9±4.3 to 3.2±3.0, p<0.001). All other questionnaires demonstrated improvements in urinary symptoms. Stress urinary incontinence rate decreased from 59.6% to 21% (p<0.001). Post-void residual (PVR) volume and Valsalva maneuver also decreased (p<0.001). CONCLUSIONS: Pelvic organ prolapse surgery reduced the prevalence of urgency symptoms, and all questionnaires on urinary symptoms showed clinically significant improvement. Vaginal surgery for POP, even combined with MUS, significantly reduced PVR volume and improved urgency symptoms.

Test-Retest Reliability of 3 Specific Strength Tests in Professional Handball Players.

CONTEXT: Current devices to assess strength performance in handball may not be sufficiently sports-specific and reliable methods. Functional electromechanical dynamometry is a new technology that allows the development of accurate strength tests in athletes. PURPOSE: To determine the absolute and relative reliability and to compare the reliability of the right and left side, and mean and peak force of 3 specific strength tests in handball players with a functional electromechanical dynamometer: unilateral pullover, standing lift, and step forward. METHODS: Fourteen male handball players of the first Spanish division (28.79 [4.81] y; 10.38 [4.63] y of professional experience) performed a repeated-measurement design. Three testing sessions were performed (one per week). The first measurement consisted of 4 isometric tests (right and left unilateral pullover, and right and left standing lift) to obtain isometric peak force, and in the second and third sessions, 6 incremental tests until failure (right and left unilateral pullover, and right and left standing lift, right and left step forward) were performed. RESULTS: The tests provided high reliability or acceptable reliability for mean and peak strength of unilateral pullover, standing lift and step forward (intraclass correlation coefficient = .83-.97; coefficient of variation = 3.90-11.57). Effect side was negligible in any of the parameters, except for a small effect side in the left peak force for unilateral pullover and a small effect side on the left side for a step forward. Significant differences in reliability (coefficient of variation ratio > 1.15) were found between the right and left sides and peak and mean force in all exercises except peak force in unilateral pullover and step forward. CONCLUSION: These results confirm that the tests could be applied to assess physical performance in handball at the same time as regular gym training. Moreover, this is an excellent opportunity to individualize the player's weekly load.

Bio-based polyester-polyurethane foams: synthesis and degradability by Aspergillus niger and Aspergillus clavatus.

In this article, the degradability by Aspergillus niger and Aspergillus clavatus of three bio-based polyurethane (PU) foams is compared to previous degradability studies involving a Pseudomonas sp. bacterium and similar initial materials (Spontón et al. in Int. Biodet. Biodeg. 85:85-94, 2013, https://doi.org/10.1016/j.ibiod.2013.05.019 ). First, three new polyester-polyurethane foams were prepared from mixtures of castor oil (CO), maleated castor oil (MACO), toluene diisocyanate (TDI), and water. Then, their degradation tests were carried out in an aqueous medium, and employing the two mentioned fungi, after their isolation from the environment. From the degradation tests, the following was observed: (a) the insoluble (and slightly collapsed) foams exhibited free hydroxyl, carboxyl, and amine moieties; and (b) the water soluble (and low molar mass) compounds contained amines, carboxylic acids, and glycerol. The most degraded foam contained the highest amount of MACO, and therefore the highest concentration of hydrolytic bonds. A basic biodegradation mechanism was proposed that involves hydrolysis and oxidation reactions.

Effects of different lower limb strengthening protocols on muscle activity, strength and power in sedentary and physically inactive subjects: a systematic review.

Introduction: The purpose of this systematic review was: a) to determine the quality of evidence from studies assessing the effects of different lower limb strengthening protocols on muscle activity, strength, and power in sedentary and/or physically inactive subjects; and b) to determine the effectiveness of lower extremity strengthening protocols on muscle activity, strength, and power in sedentary and/or physically inactive subjects. Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statements were followed using keywords associated with strength training, lower limb, sedentary, and physical inactivity. Four databases were used: Medline via PubMed, Web of Science, Scopus and SPORTDiscus. Methodological quality was assessed using the PEDro scale. A total of 164 articles were retrieved, six included in this review. Four studies were classified as fair methodological quality, and two were considered of good methodological quality. Due to the heterogeneity in methodological aspects and the limited number of articles including the variables under study, it was not possible to establish a measure of effectiveness of lower limb strengthening protocols on muscle activity, strength, or power. In conclusion, strength training in the lower limb seems to improve the levels of strength, power, and muscular activity in sedentary subjects. However, due to the limited number of articles, methodological variability, and training methods used, it is necessary to conduct new studies that control these variables.

Introducción: El propósito de esta revisión sistemática fue: a) determinar la calidad de la evidencia de los estudios que evaluaron los efectos de diferentes protocolos de fortalecimiento de miembros inferiores sobre la actividad, la fuerza y la potencia muscular en sujetos sedentarios y/o físicamente inactivos; y b) determinar la efectividad de los protocolos de fortalecimiento sobre la actividad, fuerza y potencia muscular de miembros inferiores en sujetos sedentarios y/o físicamente inactivos. Se siguieron los criterios PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyse) utilizando palabras clave asociadas con el entrenamiento de fuerza, extremidades inferiores, sedentarismo e inactividad física. Se revisaron cuatro bases de datos: Medline vía PubMed, Web of Science, Scopus y SPORTDiscus. La calidad metodológica se evaluó mediante la escala PEDro. Se recuperaron 164 artículos en total, seis incluidos en esta revisión. Cuatro estudios se clasificaron como de calidad metodológica regular y dos se consideraron de buena calidad metodológica. Debido a la heterogeneidad en los aspectos metodológicos y al escaso número de artículos que incluyeron las variables en estudio, no fue posible establecer una medida de efectividad de los protocolos de fortalecimiento de miembros inferiores sobre la actividad, la fuerza o la potencia muscular. En conclusión, el entrenamiento de fuerza en el miembro inferior parece mejorar los niveles de fuerza, potencia y actividad muscular en sujetos sedentarios. No obstante, debido al número limitado de artículos, la variabilidad metodológica y los métodos de entrenamiento utilizados, es necesario realizar nuevos estudios que controlen estas variables.

Reliability of a handball specific strength test battery and the association with sprint and throwing performance in young handball players.

BACKGROUND: A greater motivation for coaches to be more involved in assessment could be the development of specific strength tests closer to specific handball tasks. Therefore, the aims were to determine the reliability of a handball specific strength test battery in young handball players using a functional electromechanical dynamometer (FEMD) and to evaluate the association between the strength test battery and performance measurements. METHODS: Thirty-two young handball players (25% males and 75% females) performed a repeated-measurement design over four weeks. The players conducted one session per week, with each measurement consisting of two isometric tests to obtain isometric peak force, and four incremental tests. Moreover, performance handball tests (sprint and throwing velocity [TV]) were recorded. RESULTS: The reliability of the whole handball specific strength tests was very high for the peak and mean strength (ICC=0.70-0.85; CV=8.49-13.99; SEM=0.44-0.67 kg). The step forward had a moderate association with 5 to 10 meters' time. The highest correlation between TVmean was found with the peak strength of standing lift and between TVpeak with peak strength of unilateral throw. The sprint total time could be explained by Body Mass Index and peak strength of the standing lift in the 40% and the TVpeak could be explained by arm span and mean strength of the standing lift in the 68%. CONCLUSIONS: The high reliability for all exercises and the significant correlation with handball performance (sprint time and TV) allow us to include these tests in handball team evaluation and training.

Para onde a roda nos levou? Uma conversa sobre promoção da saúde sexual para populações sexo-dissidentes / Where has the circle taken us? A conversation on sexual health promotion for sex-dissident populations

Resumo O texto discute os desafios para promoção da saúde de homens que fazem sexo com homens (HSHs) por meio de dados oriundos de uma roda de conversa, com pessoas de instituições que prestam serviços para HSHs na Região Metropolitana do Recife. Os resultados permitiram identificar desafios para o trabalho de promoção à saude, não só para HSHs, mas para pessoas sexo-dissidentes: dificuldades com o uso das categorias de identidade; estigmatização por prestar-lhes cuidado em saúde sexual; racismo estrutural; contexto de privação de liberdade; extrema pobreza; letramento.

Abstract This work discusses the health promotion challenges of men who have sex with men (MSM) through the use of data from a conversation circle with people from institutions that provide services to MSM in the Metropolitan Region of Recife. The results allow for the identification of the following challenges for health promotion work, not only for MSM but also for sex dissidents: difficulties with the use of identity categories, stigmatization for providing them with sexual health care, structural racism, the deprivation of liberty, extreme poverty, and literacy.

Vertical Versus Horizontal Training for Improving the Change of Direction Speed in Adult Basketball Players: A Systematic Review and Meta-analysis.

ABSTRACT: Barrera-Domínguez, FJ, Martínez-García, D, Jerez-Mayorga, D, Chirosa-Ríos, LJ, Almagro, BJ, and Molina-López, J. Vertical versus horizontal training for improving the change of direction speed in adult basketball players: a systematic review and meta-analysis. J Strength Cond Res XX(X): 000-000, 2023-The ability to perform changes of direction (COD) is a complex skill that involves the application of multiple force-orientations, and its execution at maximum speed is crucial in basketball players. The present study aimed to synthesize findings from previous interventions classified according to force-orientation (vertical, horizontal, or mixed) and determine their magnitude of the effect on COD performance in basketball players. A systematic review of the literature was performed in several databases (Web of Science, Scopus, SPORTDiscus, and PubMed) following the PRISMA statement and reviewed the quality of the included papers according to the Cochrane Collaboration Guidelines Assessment. Sixteen articles with a total of 21 reports were included to analyze the role of force-orientations in COD performance. For the meta-analysis, the standardized mean differences with 95% confidence intervals (CIs) were calculated to determine the chronic changes induced by training and performed an effect size (ES) analysis with a random-effects model. The results showed that all force-orientations generated improvements in COD performance (ES = -0.47 [95% CI -0.57, -0.36], Z = 8.74 [p < 0.01]). It was a mixed force-orientation that produced the greatest changes (ES = -0.91 [95% CI -1.27, -0.55], Z = 4.96 [p < 0.01]), followed by vertical training (ES = -0.45 [95% CI -0.70, -0.20], Z = 3.51 [p < 0.01]). Horizontal training was the least studied and showed the smallest change (ES = -0.10 [95% CI -0.14, -0.07], Z = 5,71 [p < 0.01]). This meta-analysis demonstrates that mixed vertical and horizontally oriented training may be the most optimal because it offers a greater variety of multidirectional stimuli that better prepares the athlete to deal with complex COD in real-game situations.