Ethnopharmacology - A journal, a definition and a society.

ETHNOPHARMACOLOGICAL RELEVANCE: Historical development of the Journal of Ethnopharmacology, the International Society of Ethnopharmacology, and the first definition of ethnopharmacology. AIM OF THE STUDY: To present the background to, and the people involved, in the foundation of the journal and the society. MATERIALS AND METHODS: Personal recollections, archival documents and photographs. RESULTS: A concise review of the early years of the JEP and the ISE, and the development of the first definition of ethnopharmacology. CONCLUSIONS: The definition of ethnopharmacology as an interdisciplinary science, and its establishment as a journal and a society was timely, filled a need, and opened up publication and meeting possibilities for scientists from various academic fields. Most important has been, and continues to be, the bridges created between people from all cultures and all countries.

Very long half-life of paroxetine following intoxication in an extensive cytochrome P4502D6 metabolizer.

A very long half-life of paroxetine (195 h instead of the usual value of around 16 h) was measured after an overdose with 2 g paroxetine and 1 g clorazepate in a patient who was an extensive cytochrome P4502D6 metabolizer. The patient recovered well without any clinically significant complications. A consequence of the close monitoring of paroxetine levels in this patient was that it was decided not to reintroduce any other antidepressant despite her suicide attempt, until normal levels of paroxetine had been reached, which took over 1 month.