RESUMO
Ultrasound examination of a 31-year-old woman at 27 weeks' gestation revealed fetal growth retardation, a bilateral cleft lip and palate, and the absence of median cerebral structures. Chromosome analysis after cordocentesis showed an abnormal karyotype with a structural abnormality of the long arm of chromosome 7: 46,XX,-7,+der(7),t(7;18) (q34;q21.3)mat. The pregnancy was terminated at week 29. The ultrasound findings were confirmed by post-mortem examination, which also revealed a semilobar holoprosencephaly.
Assuntos
Anormalidades Múltiplas/genética , Deleção Cromossômica , Cromossomos Humanos Par 18 , Cromossomos Humanos Par 7 , Translocação Genética , Trissomia , Anormalidades Múltiplas/diagnóstico por imagem , Aborto Terapêutico , Adulto , Bandeamento Cromossômico , Fenda Labial/diagnóstico por imagem , Fenda Labial/genética , Fissura Palatina/diagnóstico por imagem , Fissura Palatina/genética , Cordocentese , Feminino , Doenças Fetais/diagnóstico por imagem , Doenças Fetais/genética , Retardo do Crescimento Fetal/diagnóstico por imagem , Retardo do Crescimento Fetal/genética , Holoprosencefalia/diagnóstico por imagem , Holoprosencefalia/genética , Humanos , Cariotipagem , Gravidez , Segundo Trimestre da Gravidez , Ultrassonografia Pré-NatalRESUMO
Mammary tumors were promoted in male rats of the Wistar WAG strain by continuous and simultaneous administration of 17 beta-estradiol and progesterone. Tumor induction and growth were dependent on estradiol and on progesterone. Their histological features were comparable with those of human breast cancers. Hormone receptors were present in tumor cells. Estradiol receptor was found in 95% of them, at a higher level in nuclei than in cytosol. Progesterone receptor was present in 75% of tumors. In all cases, the level of androgen receptor was low.
Assuntos
Estradiol , Neoplasias Mamárias Experimentais/análise , Progesterona , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Animais , Masculino , Neoplasias Mamárias Experimentais/induzido quimicamente , Ratos , Ratos Endogâmicos , Receptores Androgênicos/análiseRESUMO
Mammary tumours were induced in rats by administration of an estradiol-progesterone association. These tumours offered close analogies with human mammary tumours. The estradiol-receptor was found both in cytosol and nuclei and was more abundant in nuclei than in cytosol. The major part of its binding sites was occupied by endogenous hormone. On the other hand, a high level of progesterone receptor was present in tumoral cytosol. This fact gave evidence of the complete activity of the estradiol receptor. The presence of estradiol and progesterone receptors in mammary tumors induced by these hormones substantiate their hormone-dependence.