Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish.

Epilepsy is one of the most common neurological disorders. The X-linked gene PCDH19 is associated with sporadic and familial epilepsy in humans, typically with early-onset clustering seizures and intellectual disability in females but not in so-called 'carrier' males, suggesting that mosaic PCDH19 expression is required to produce epilepsy. To characterize the role of loss of PCDH19 function in epilepsy, we generated zebrafish with truncating pcdh19 variants. Evaluating zebrafish larvae for electrophysiological abnormalities, we observed hyperexcitability phenotypes in both mosaic and non-mosaic pcdh19+/- and pcdh19-/- mutant larvae. Thus, we demonstrate that the key feature of epilepsy-network hyperexcitability-can be modeled effectively in zebrafish, even though overt spontaneous seizure-like swim patterns were not observed. Further, zebrafish with non-mosaic pcdh19 mutation displayed reduced numbers of inhibitory interneurons suggesting a potential cellular basis for the observed hyperexcitability. Our findings in both mosaic and non-mosaic pcdh19 mutant zebrafish challenge the prevailing theory that mosaicism governs all PCDH19-related phenotypes and point to interneuron-mediated mechanisms underlying these phenotypes.

Bose polarons near quantum criticality.

The emergence of quasiparticles in interacting matter represents one of the cornerstones of modern physics. However, in the vicinity of a quantum critical point, the existence of quasiparticles comes under question. Here, we created Bose polarons near quantum criticality by immersing atomic impurities in a Bose-Einstein condensate (BEC) with near-resonant interactions. Using radiofrequency spectroscopy, we probed the energy, spectral width, and short-range correlations of the impurities as a function of temperature. Far below the superfluid critical temperature, the impurities formed well-defined quasiparticles. Their inverse lifetime, given by their spectral width, increased linearly with temperature at the so-called Planckian scale, consistent with quantum critical behavior. Close to the BEC critical temperature, the spectral width exceeded the impurity's binding energy, signaling a breakdown of the quasiparticle picture.

High numerical aperture (NA = 0.92) objective lens for imaging and addressing of cold atoms.

We have designed, built, and characterized a high-resolution objective lens that is compatible with an ultrahigh vacuum environment. The lens system exploits the principle of the Weierstrass sphere solid immersion lens to reach a numerical aperture (NA) of 0.92. Tailored to the requirements of optical lattice experiments, the objective lens features a relatively long working distance of 150 µm. Our two-lens design is remarkably insensitive to mechanical tolerances in spite of the large NA. Additionally, we demonstrate the application of a tapered optical fiber tip, as used in scanning near-field optical microscopy, to measure the point spread function (PSF) of a high NA optical system. From the PSF, we infer the wavefront aberration for the entire field of view of about 75 µm. Pushing the NA of an optical system to its ultimate limit enables novel applications in quantum technologies such as quantum control of atoms in optical microtraps with an unprecedented spatial resolution and photon collection efficiency.

Low-Entropy States of Neutral Atoms in Polarization-Synthesized Optical Lattices.

We create low-entropy states of neutral atoms by utilizing a conceptually new optical-lattice technique that relies on a high-precision, high-bandwidth synthesis of light polarization. Polarization-synthesized optical lattices provide two fully controllable optical lattice potentials, each of them confining only atoms in either one of the two long-lived hyperfine states. By employing one lattice as the storage register and the other one as the shift register, we provide a proof of concept using four atoms that selected regions of the periodic potential can be filled with one particle per site. We expect that our results can be scaled up to thousands of atoms by employing an atom-sorting algorithm with logarithmic complexity, which is enabled by polarization-synthesized optical lattices. Vibrational entropy is subsequently removed by sideband cooling methods. Our results pave the way for a bottom-up approach to creating ultralow-entropy states of a many-body system.

Atomic "bomb testing": the Elitzur-Vaidman experiment violates the Leggett-Garg inequality.

Elitzur and Vaidman have proposed a measurement scheme that, based on the quantum superposition principle, allows one to detect the presence of an object-in a dramatic scenario, a bomb-without interacting with it. It was pointed out by Ghirardi that this interaction-free measurement scheme can be put in direct relation with falsification tests of the macro-realistic worldview. Here we have implemented the "bomb test" with a single atom trapped in a spin-dependent optical lattice to show explicitly a violation of the Leggett-Garg inequality-a quantitative criterion fulfilled by macro-realistic physical theories. To perform interaction-free measurements, we have implemented a novel measurement method that correlates spin and position of the atom. This method, which quantum mechanically entangles spin and position, finds general application for spin measurements, thereby avoiding the shortcomings inherent in the widely used push-out technique. Allowing decoherence to dominate the evolution of our system causes a transition from quantum to classical behavior in fulfillment of the Leggett-Garg inequality.

Note: Ultra-low birefringence dodecagonal vacuum glass cell.

We report on an ultra-low birefringence dodecagonal glass cell for ultra-high vacuum applications. The epoxy-bonded trapezoidal windows of the cell are made of SF57 glass, which exhibits a very low stress-induced birefringence. We characterize the birefringence Δn of each window with the cell under vacuum conditions, obtaining values around 10(-8). After baking the cell at 150 °C, we reach a pressure below 10(-10) mbar. In addition, each window is antireflection coated on both sides, which is highly desirable for quantum optics experiments and precision measurements.

Note: In situ measurement of vacuum window birefringence by atomic spectroscopy.

We present an in situ method to measure the birefringence of a single vacuum window by means of microwave spectroscopy on an ensemble of cold atoms. Stress-induced birefringence can cause an ellipticity in the polarization of an initially linearly polarized laser beam. The amount of ellipticity can be reconstructed by measuring the differential vector light shift of an atomic hyperfine transition. Measuring the ellipticity as a function of the linear polarization angle allows us to infer the amount of birefringence Δn at the level of 10(-8) and identify the orientation of the optical axes. The key benefit of this method is the ability to separately characterize each vacuum window, allowing the birefringence to be precisely compensated in existing vacuum apparatuses.