RESUMO
The antiviral and interferon-inducing activity of saparal, an adaptogen of plant origin, was studied. Tests in experimental mice demonstrated the interferon-inducing activity of saparal providing its antiviral effect. An optimal scheme of saparal administration was developed. The preparation had no direct inhibitory effect on influenza virus replication. The application of saparal for prophylaxis among workers resulted in a 2-fold or greater decrease of influenza and other ARD morbidity and in an increase of endogenous serum interferon level in 67-75% of the persons examined.
Assuntos
Antivirais/uso terapêutico , Vírus da Influenza A , Influenza Humana/tratamento farmacológico , Indutores de Interferon/uso terapêutico , Extratos Vegetais/uso terapêutico , Animais , Células Cultivadas , Embrião de Galinha , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Humanos , Vírus da Influenza A/efeitos dos fármacos , Influenza Humana/sangue , Influenza Humana/epidemiologia , Influenza Humana/prevenção & controle , Interferons/sangue , Interferons/efeitos dos fármacos , Camundongos , Federação Russa/epidemiologia , Estações do AnoRESUMO
In four controlled observations on the organized groups of students and industrial workers during the epidemics of influenza A in 1988-1989 Arbidol, a new chemopreparation, was found to be well tolerated and to produce a pronounced prophylactic effect when administered in a dose of 0.2 g (2 tablets of 0.1 g) daily for 10-18 days. After the 18-day prophylactic course of Arbidol the induction of serum interferon was found.