RESUMO
An increasing number of Australians are being admitted to hospitals and day procedure centers to have dental treatment under a dental general anesthetic (DGA). Children younger than 2 y are having DGAs. These operations are costly and, although there have been improvements in safety, are not without risk. Most DGAs in children are to treat dental caries and have been defined as potentially preventable dental hospitalizations (PPDHs). This article reports on an analysis of the impact of access to community water fluoridation (CWF), availability of oral health professionals (OHPs), and socioeconomic status (SES) on PPDHs of 0- to 4-y-olds in 2012-2013 in Victoria, Australia. Data on these variables were obtained at the community (postcode) level. From the negative binomial multivariate analysis, each of the 3 independent variables was independently significantly associated with PPDHs at the postcode level. Children residing in postcodes without CWF on average had 59% higher rates than those with access (incident rate ratio [IRR], 1.59; P < 0.0001), children in postcodes with the lowest level of availability of OHPs had 65% higher rates than those with the highest access (IRR, 1.65; P < 0.0001), and children living in the most disadvantaged SES quintiles had 57% higher rates than children in the most advantaged quintiles (IRR, 1.57; P < 0.0001). There was a stepwise social gradient by SES quintile. In analysis of access to CWF and SES status, children without access to CWF had 86% higher PPDH rates than children with access (IRR, 1.86; P < 0.0001). In summary, no access to CWF, poor availability of OHPs, and lower SES status were independently associated with higher PPDH rates among 0- to 4-y-olds in Victoria at the postcode level. The study highlights the importance of considering 3 interacting factors-access to CWF, access to OHPs, and SES-in efforts to reduce PPDH rates in young children. Knowledge Transfer Statement: Extending access to water fluoridation, increasing the availability of dental services, and raising disadvantaged families' socioeconomic status are each likely to decrease the rate of dental general anesthetics in young children.
Assuntos
Cárie Dentária , Criança , Pré-Escolar , Fluoretação , Hospitalização , Humanos , Saúde Bucal , VitóriaRESUMO
Ensuring equitable and fair organ allocation is a central charge of the United Network for Organ Sharing (UNOS) as the Organ Procurement and Transplantation Network (OPTN) through its contract with the Department of Health and Human Services (DHHS). The OPTN/UNOS Board initiated a reassessment of the current allocation system. This paper describes the efforts of the OPTN/UNOS Heart Subcommittee, acting on behalf of the OPTN/UNOS Thoracic Organ Transplantation Committee, to modify the current allocation system. The Subcommittee assessed the limitations of the current three-tiered system, outcomes of patients with status exceptions, emerging ventricular assist device (VAD) population, options for improved geographic sharing and status of potentially disenfranchised groups. They analyzed waiting list and posttransplant mortality rates of a contemporary cohort of patient groups at risk, in collaboration with the Scientific Registry of Transplant Recipients to develop a proposed multi-tiered allocation scheme. This proposal provides a framework for simulation modeling to project whether candidates would have better waitlist survival in the revised allocation system, and whether posttransplant survival would remain stable. The tiers are subject to change, based on further analysis by the Heart Subcommittee and will lead to the development of a more effective and equitable heart allocation system.
Assuntos
Alocação de Recursos para a Atenção à Saúde , Cardiopatias/cirurgia , Transplante de Coração , Alocação de Recursos , Obtenção de Tecidos e Órgãos , Adulto , Doação Dirigida de Tecido , Humanos , Estados Unidos , Listas de EsperaAssuntos
Transplante de Fígado , Obtenção de Tecidos e Órgãos , Adulto , Coração Auxiliar , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Receptores de Ativinas Tipo I/genética , Proteínas de Transporte/genética , Miosite Ossificante/genética , Alelos , Mapeamento Cromossômico , Cromossomos Humanos Par 2/genética , Análise Mutacional de DNA , Triagem de Portadores Genéticos , Humanos , Mutação de Sentido Incorreto , Reação em Cadeia da Polimerase , Valor Preditivo dos Testes , Terminologia como AssuntoRESUMO
The influence of age on outcomes after left ventricular assist device (LVAD) implantation is not well studied. To address this question, we assessed 222 patients who underwent LVAD placement and were divided into quartiles based on age (years): group 1,
Assuntos
Coração Auxiliar , Adulto , Fatores Etários , Idoso , Feminino , Coração Auxiliar/efeitos adversos , Humanos , Infecções/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/epidemiologia , Reoperação , Estudos Retrospectivos , Análise de Sobrevida , Resultado do TratamentoRESUMO
The 21Na(p,gamma)22Mg reaction is expected to play an important role in the nucleosynthesis of 22Na in oxygen-neon novae. The decay of 22Na leads to the emission of a characteristic 1.275 MeV gamma-ray line. This report provides the first direct measurement of the rate of this reaction using a radioactive 21Na beam, and discusses its astrophysical implications. The energy of the important state was measured to be E(c.m.)=205.7+/-0.5 keV with a resonance strength omegagamma=1.03+/-0.16(stat)+/-0.14(sys) meV.
RESUMO
This qualitative study examined the pregnancy, birth and postpartum experiences of 12 women with mobility-limiting physical disabilities. Analysis of semi-structured interviews of one to two hours revealed that the women's experiences were influenced by their own perspectives and the characteristics of health care system within which they were treated. The woman's experience included the effect of her disability, her resources, and her personality and approach. Health care system factors included provider attitudes, knowledge about disability and structural and political factors. Implications for health care providers are described.
Assuntos
Atividades Cotidianas , Adaptação Psicológica , Atitude Frente a Saúde , Pessoas com Deficiência/psicologia , Trabalho de Parto/psicologia , Complicações na Gravidez/psicologia , Adulto , Atitude do Pessoal de Saúde , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Pesquisa Metodológica em Enfermagem , Personalidade , Gravidez , Apoio Social , Inquéritos e QuestionáriosRESUMO
This article describes cultural and social issues related to disability based on the authors' experiences as researchers, clinicians, and activists and personal experience. They address the complexity of the topic of disability subculture by arguing that there is not one disability subculture and then describe common themes that characterize the social context of people with disabilities and one highly visible disability subculture. Clinical and research implications are mentioned. The definition of culturally competent care should be broadened to include disability.
Assuntos
Características Culturais , Pessoas com Deficiência , Humanos , Condições SociaisRESUMO
A disorder affecting bone and cartilage growth is described in a mother and her 3-year-old son. A dysplastic process involving the vertebral bodies, most pronounced in the cervical region and leading to cervical dislocation in the first of these two patients, is the most significant complication of this disorder. This entity appears unrelated to other previously described skeletal dysplasias with cervical kyphosis as a major manifestation. This disorder is most likely autosomal dominant.
Assuntos
Osso e Ossos/anormalidades , Cartilagem/anormalidades , Anormalidades Congênitas/genética , Cromossomo X/genética , Adulto , Osso e Ossos/diagnóstico por imagem , Pré-Escolar , Diagnóstico Diferencial , Feminino , Ligação Genética , Humanos , Masculino , Radiografia , Coluna Vertebral/anormalidadesRESUMO
BACKGROUND: Photopheresis is an immunoregulatory technique in which lymphocytes are reinfused after exposure to a photoactive compound (methoxsalen) and ultraviolet A light. We performed a preliminary study to assess the safety and efficacy of photopheresis in the prevention of acute rejection of cardiac allografts. METHODS: A total of 60 consecutive eligible recipients of primary cardiac transplants were randomly assigned to standard triple-drug immunosuppressive therapy (cyclosporine, azathioprine, and prednisone) alone or in conjunction with photopheresis. The photopheresis group received a total of 24 photopheresis treatments, each pair of treatments given on two consecutive days, during the first six months after transplantation. The regimen for maintenance immunosuppression, the definition and treatment of rejection episodes, the use of prophylactic antibiotics, and the schedule for cardiac biopsies were standardized among all 12 study centers. All the cardiac-biopsy samples were graded in a blinded manner at a central pathology laboratory. Plasma from the subgroup of 34 patients (57 percent) who were enrolled at the nine U.S. centers was analyzed by polymerase-chain-reaction amplification for cytomegalovirus DNA. RESULTS: After six months of follow-up, the mean (+/-SD) number of episodes of acute rejection per patient was 1.44+/-1.0 in the standard-therapy group, as compared with 0.91+/-1.0 in the photopheresis group (P=0.04). Significantly more patients in the photopheresis group had one rejection episode or none (27 of 33) than in the standard-therapy group (14 of 27), and significantly fewer patients in the photopheresis group had two or more rejection episodes (6 of 33) than in the standard-therapy group (13 of 27, P=0.02). There was no significant difference in the time to a first episode of rejection, the incidence of rejection associated with hemodynamic compromise, or survival at 6 and 12 months. Although there were no significant differences in the rates or types of infection, cytomegalovirus DNA was detected significantly less frequently in the photopheresis group than in the standard-therapy group (P=0.04). CONCLUSIONS: In this pilot study, the addition of photopheresis to triple-drug immunosuppressive therapy significantly decreased the risk of cardiac rejection without increasing the incidence of infection.
Assuntos
Rejeição de Enxerto/prevenção & controle , Transplante de Coração , Imunossupressores/uso terapêutico , Fotoferese , Terapia Combinada , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/epidemiologia , Feminino , Humanos , Terapia de Imunossupressão/métodos , Incidência , Infecções/epidemiologia , Masculino , Pessoa de Meia-Idade , Análise de SobrevidaRESUMO
Achondroplasia is the most prevalent chondrodysplasia and numerous authors have documented the varied social and medical complications that may compromise a full and productive life. Complications include cervicomedullary compression, spinal stenosis, restrictive and obstructive lung disease, otitis media, and tibial bowing, among others. These known complications have led to recommendations for the anticipatory management of such patients. There are relatively few data on the actual rates and timing of these problems. This paper reports data on the rates and age of occurrence of several of these complications based on a review of recorded chart information of 193 patients ascertained from several well established genetic centres with a known interest in the chondrodysplasias. The length of follow up varied and the rates of occurrence at specific age intervals were used to estimate the cumulative percentage affected for each complication. The report includes information on otitis media, ventilation tubes, hearing loss, tonsillectomy, speech problems, tibial bowing and osteotomy, ventricular shunting, apnoea, cervicomedullary decompression, and neurological signs attributable to spinal stenosis.
Assuntos
Acondroplasia/complicações , Estudos Transversais , Feminino , Humanos , Masculino , Estudos ProspectivosRESUMO
UNLABELLED: Severe behavioural disturbance is a very common feature of Sanfilippo syndrome (mucopolysaccharidosis III, MPSIII), and one of the more difficult aspects of the disease to treat. We describe a series of six patients with MPS III who had cerebrospinal shunts inserted in an attempt to ameliorate behaviour that had proved refractory to conventional treatment. Symptoms improved significantly in all six but removal of the shunt was necessitated in one patient due to shunt blockage and infection. CONCLUSION: Our experience suggests cerebrospinal fluid shunting should be formally evaluated as an adjunct to conventional forms of treatment of extreme behavioural disturbance in MPS III.
Assuntos
Derivações do Líquido Cefalorraquidiano , Transtornos do Comportamento Infantil/cirurgia , Mucopolissacaridose III/cirurgia , Adolescente , Criança , Transtornos do Comportamento Infantil/genética , Pré-Escolar , Terapia Combinada , Falha de Equipamento , Feminino , Seguimentos , Humanos , Masculino , Mucopolissacaridose III/genética , Reoperação , Resultado do Tratamento , Derivação VentriculoperitonealRESUMO
Fibrodysplasia ossificans progressiva is an autosomal dominant disorder. Most cases are due to new gene mutations because people with fibrodysplasia ossificans progressiva have markedly reduced reproductive fitness. The gene or genes responsible for this disorder are unknown.
Assuntos
Miosite Ossificante/genética , Criança , Feminino , Aconselhamento Genético , Humanos , Masculino , Mosaicismo , RiscoRESUMO
The plasminogen activator inhibitor type 1 (PAI-1) gene encodes the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and is induced by cytokines such as transforming growth factor-beta (TGF-beta). Studies have identified DNA sequence elements within the first 1.3 kb of the 5'-upstream DNA that mediate cytokine responsiveness in transfected cells in vitro. However, the DNA sequences that mediate PAI-1 expression in vivo have not yet been delineated. To define these regulatory sequences, we generated transgenic mice that expressed a hybrid gene comprising sequences between -1,272 and +75 of the human PAI-1 gene ligated to a LacZ reporter gene. Transgene expression detected in two independent lines was observed only in kidney from embryonic day 13 to adult and was seen primarily in proximal tubule cells of the outer medulla. Transgene expression and activity were unchanged in response to TGF-beta and remained restricted to kidney. Thus we have identified a promoter region within the PAI-1 gene that targets transgene expression to kidney but, unlike the native promoter, is unresponsive to TGF-beta in the experimental protocol used.
Assuntos
Rim/metabolismo , Inibidor 1 de Ativador de Plasminogênio/genética , Regiões Promotoras Genéticas , Animais , Southern Blotting , Desoxirribonuclease BamHI/metabolismo , Expressão Gênica , Humanos , Camundongos , Camundongos Transgênicos , Especificidade de Órgãos , RNA Mensageiro/análise , RNA Mensageiro/metabolismo , Proteínas Recombinantes de Fusão , Sequências Reguladoras de Ácido Nucleico , Fator de Crescimento Transformador beta/farmacologia , beta-Galactosidase/genéticaRESUMO
Interest in transmyocardial laser revascularization for the treatment of otherwise inoperable coronary artery disease has increased rather dramatically in recent years. The results of several industrially sponsored clinical series have been reported recently, all with significant improvement in angina pectoris that appears both rapid and sustained. In most instances, an associated improvement in exercise tolerance has been reported. Improvement in regional myocardial perfusion has been proclaimed, although it is less consistent and less complete than symptom relief. The mechanisms whereby this clinical effect is achieved remain unknown. Histologic analysis of autopsy material has yielded somewhat conflicting results regarding the persistent patency of laser-created channels. The results of laboratory investigations of this therapy have been equally inconsistent. Despite our ignorance regarding the mechanism of angina relief, clinical experience continues to grow. In addition to the CO2 laser energy source used in early studies, trials of alternative devices using holmium:yttrium-aluminum-garnet and eximer lasers are underway. The latter two employ fiberoptic technology and are currently under development for endovascular approaches.
Assuntos
Angina Pectoris/cirurgia , Doença das Coronárias/cirurgia , Ventrículos do Coração/cirurgia , Terapia a Laser/instrumentação , Angioplastia Coronária com Balão/instrumentação , Angioplastia a Laser/instrumentação , Ensaios Clínicos como Assunto , Circulação Coronária/fisiologia , Doença das Coronárias/fisiopatologia , Desenho de Equipamento , Teste de Esforço , Ventrículos do Coração/fisiopatologia , Humanos , Isquemia Miocárdica/fisiopatologia , Isquemia Miocárdica/cirurgia , Resultado do TratamentoRESUMO
Pitt-Rogers-Danks syndrome (PRDS) is a rare, presumed autosomal recessive, syndrome with pre- and postnatal growth retardation, microcephaly, characteristic facial appearance, seizures, unusual palmar creases and developmental delay. Since the first description in 1984, only 7 cases have been reported. We report the identification of a 4p microdeletion in 2 new patients, who were previously diagnosed with PRDS, as well as the sibs in Pitt et al. [1984]. PRDS can no longer be considered autosomal recessive. Although our cases are attributable to a microdeletion in 4p16, it is uncertain if the critical region involves a single locus or multiple loci or to what extent this region overlaps with the critical region for Wolf-Hirschhorn syndrome.
Assuntos
Anormalidades Múltiplas/genética , Cromossomos Humanos Par 4 , Deleção de Genes , Criança , Sondas de DNA , Face/anormalidades , Feminino , Marcadores Genéticos , Transtornos do Crescimento/genética , Humanos , Lactente , Deficiência Intelectual/genética , Masculino , SíndromeRESUMO
The skeleton of a child with osteogenesis imperfecta type III, resulting from the substitution of glycine 586 by valine in the triple helical domain of the alpha 2 (I) chain of type I collagen, was severely porotic but contained lamellar bone and Haversian systems. From early childhood, structural failure of the bone resulted in the disruption of growth plates, progressive bone deformities, and severe growth retardation.
Assuntos
Colágeno/genética , Lâmina de Crescimento/patologia , Mutação , Osteogênese Imperfeita/genética , Osteogênese Imperfeita/patologia , Adolescente , Adulto , Braço/anormalidades , Braço/patologia , Osso e Ossos/diagnóstico por imagem , Pré-Escolar , Colágeno/química , Feminino , Glicina/genética , Humanos , Recém-Nascido , Masculino , Osteogênese Imperfeita/diagnóstico por imagem , Gravidez , Radiografia , Tórax/anormalidades , Valina/genéticaRESUMO
The mucopolysaccharidoses are a group of inherited disorders of metabolism, with varying clinical manifestations. A number of them present anaesthetic difficulties. This paper presents a summary table of the syndromes and reviews our experience over ten years with patients with these diagnoses. The clinical presentations, anaesthetic management, and complications are described. The effect of age and diagnosis on airway difficulties was studied. There were 31 patients, 28 of whom required anaesthesia, on a total of 99 occasions, for 115 procedures. The patients with Hunter, Hurler and Maroteaux-Lamy syndromes had significantly more airway difficulties as they grew older, and compared with patients in this group with other syndromes. Patients with Hurler's syndrome may have coronary artery involvement and one patient was given fentanyl and pancuronium for this reason. He proved impossible to intubate and an emergency tracheostomy was performed.
Assuntos
Anestesia Geral , Anestésicos Intravenosos , Mucopolissacaridoses/fisiopatologia , Tiopental , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Intubação Intratraqueal , Masculino , Mucopolissacaridoses/classificação , Medicação Pré-AnestésicaRESUMO
We report an infant with pre- and postnatal microcephaly and growth retardation, a distinctive face, and developmental delay. The initial diagnosis was of Seckel syndrome. He became pancytopenic at 16 months and died soon after. His bone marrow was of normal cellularity but had a small lymphocyte infiltration. Increased spontaneous chromosome breakage was seen in blood and fibroblasts. Mitomycin C induced chromosome damage was increased and comparable to that seen in Fanconi anaemia. Reports of similar patients are reviewed. This entity of severe intrauterine growth retardation and increased mitomycin C sensitivity is hypothesised to be a distinct chromosome breakage syndrome.
Assuntos
Aberrações Cromossômicas/genética , Retardo do Crescimento Fetal/etiologia , Retardo do Crescimento Fetal/genética , Mitomicina/farmacologia , Adulto , Células Cultivadas , Transtornos Cromossômicos , Fragilidade Cromossômica , Dano ao DNA , Reparo do DNA/genética , Resistência a Medicamentos , Feminino , Retardo do Crescimento Fetal/complicações , Fibroblastos/citologia , Fibroblastos/efeitos dos fármacos , Fibroblastos/efeitos da radiação , Idade Gestacional , Humanos , Lactente , Recém-Nascido , Linfócitos/fisiologia , Masculino , Fenótipo , Gravidez , Troca de Cromátide Irmã , Pele/ultraestrutura , Raios XRESUMO
Type X collagen is a homotrimer of alpha 1(X) chains encoded by the COL10A1 gene. It is a highly specialized extracellular matrix component, and its synthesis is restricted to hypertrophic chondrocytes in the calcifying cartilage of the growth plate and in zones of secondary ossification. Our studies on a family with Schmid metaphyseal chondrodysplasia demonstrated that the affected individuals were heterozygous for a single base substitution in the COL10A1 gene, which changed the codon GGC for glycine 618 to GTC for valine in the highly conserved region of the carboxyl-terminal NC1 domain and altered the amino acid sequence in the putative oligosaccharide attachment site. Since hypertrophic cartilage tissues or cell cultures were not available to assess the effect of the mutation, an in vitro cDNA expression system was used to study normal and mutant type X collagen biosynthesis and assembly. Full-length cDNA constructs of the normal type X collagen sequence and also cDNA containing the specific Gly to Val NC1 mutation found in the patient were produced and expressed by in vitro transcription and translation. While the control construct produced type X collagen, which formed trimeric collagen monomers and assembled into larger multimeric assemblies, the mutant collagen was unable to form these larger aggregates. These experiments demonstrated that the mutation disturbed type X collagen NC1 domain interaction and assembly, a finding consistent with the abnormal disorganized cartilage growth plate seen in the patient. These studies provide the first evidence of the effect of a type X collagen mutation on protein structure and function and directly demonstrate the critical role of interactions between NC1 domains in the formation of type X collagen multimeric structures in vitro.