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1.
Klin Monbl Augenheilkd ; 229(11): 1138-41, 2012 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-23011607

RESUMO

During an excavation in Regensburg/Germany the skeleton of an approximately 20-year-old Roman man was found who was buried in the 3rd/4th century after Christ. A "stone" was found which fitted into the left orbit precisely. After a thorough investigation of the "stone" and with the ophthalmohistorical literature in mind an orbital "implant" as well as a petrified medical paste ("Kollyrium") could be ruled out almost with certainty. Possibly the "stone" served another medical purpose or was used for protection of the eye.


Assuntos
Oftalmologia/história , Implantes Orbitários/história , Adulto , História Antiga , Humanos , Masculino , Paleopatologia , Cidade de Roma
3.
J Invest Dermatol ; 116(5): 721-7, 2001 May.
Artigo em Inglês | MEDLINE | ID: mdl-11348460

RESUMO

Interleukin-10 is an important anti-inflammatory and immunosuppressive cytokine with major impact on several immune reactions, including regulatory mechanisms in the skin. Recently, we performed a phase II trial in psoriatic patients receiving subcutaneously interleukin-10 over 7 wk. The clinical response suggested that interleukin-10 might represent a novel anti-psoriatic drug. In order to understand better the mode of action and to elucidate the effects of systemic interleukin-10 treatment on the skin immune system, skin punch biopsies from sites different from interleukin-10 injection were analyzed. Biopsies were obtained from the patients before, at the end, and 3 wk after interleukin-10 therapy. The results are reported here. Histologic examination showed a decrease of several parameters reflecting the psoriatic disease activity as acanthosis and extension of the horny layer. Immunohistologic examination demonstrated decreasing numbers of infiltrating T cells, dermal CD1a+ cells, and a diminished proliferation of epidermal cells. Using a novel, quantitative reverse transcriptase-polymerase chain reaction approach a significant shift within the cytokine pattern was found. Interleukin-10 therapy led to a decrease of cutaneous interleukin-8 and interleukin-10 mRNA expression. Whereas no significant changes of interleukin-6, tumor necrosis factor-alpha, and interferon-gamma expression were found, interleukin-4 was strongly upregulated suggesting a shift from a type 1 towards a type 2 cytokine pattern. The changes within the local cytokine pattern seem to be disease-related, as an inverse course was found in a single interleukin-10 nonresponding patient. Our findings demonstrate considerable effects of systemic interleukin-10 application on the skin immune systems, which might contribute to the anti-psoriatic activity of interleukin-10.


Assuntos
Interleucina-10/uso terapêutico , Psoríase/tratamento farmacológico , Pele/efeitos dos fármacos , Adulto , Citocinas/genética , Humanos , Imuno-Histoquímica , Biologia Molecular/métodos , Psoríase/imunologia , Psoríase/metabolismo , Psoríase/patologia , RNA Mensageiro/metabolismo , Pele/imunologia , Pele/metabolismo , Pele/patologia
7.
Methods Inf Med ; 35(2): 127-41, 1996 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8755386

RESUMO

The data of a patient undergoing complex diagnostic and therapeutic procedures do not only form a simple chronology of events, but are closely related in many ways. Such data contexts include causal or temporal relationships, they express inconsistencies and revision processes, or describe patient-specific heuristics. The knowledge of data contexts supports the retrospective understanding of the medical decision-making process and is a valuable base for further treatment. Conventional data models usually neglect the problem of context knowledge, or simply use free text which is not processed by the program. In connection with the development of the knowledge-based system THEMPO (Therapy Management in Pediatric Oncology), which supports therapy and monitoring in pediatric oncology, a graph-grammar approach has been used to design and implement a graph-oriented patient model which allows the representation of non-trivial (causal, temporal, etc.) clinical contexts. For context acquisition a mouse-based tool has been developed allowing the physician to specify contexts in a comfortable graphical manner. Furthermore, the retrieval of contexts is realized with graphical tools as well.


Assuntos
Gráficos por Computador , Documentação/métodos , Sistemas Computadorizados de Registros Médicos , Neoplasias/terapia , Sistemas de Notificação de Reações Adversas a Medicamentos , Inteligência Artificial , Criança , Técnicas de Apoio para a Decisão , Sistemas Inteligentes , Humanos , Armazenamento e Recuperação da Informação , Software , Terapia Assistida por Computador , Vocabulário Controlado
8.
J Reprod Fertil ; 65(2): 411-7, 1982 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7201518

RESUMO

Strange males and females blocked implantation in recently mated female Mongolian gerbils. Even the presence of the partner male failed to annul the influence. The females were, however, affected only when not lactating (e.g. in first pregnancies or when a litter had died). Pregnancies could also be ended by alterations of the caging conditions, but there were quantitative differences between social and non-social influences, both in numbers of females reacting and in their subsequent fertility. These results with gerbils do not support the suggestion that the biological advantage of pregnancy blocking lies in enhanced male reproductive success.


Assuntos
Implantação do Embrião , Gerbillinae/fisiologia , Meio Social , Agressão , Animais , Animais Recém-Nascidos , Feminino , Humanos , Lactação , Masculino , Gravidez
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