Peripartum Cardiomyopathy: A Case Report of Mortality From a Rare and Potentially Fatal Condition.

Peripartum cardiomyopathy (PPCM) poses a significant challenge in maternal health, characterized by heart failure with reduced ejection fraction during late pregnancy or early postpartum. Despite advances in understanding PPCM, it remains life-threatening with substantial maternal morbidity and mortality. This article reviews the epidemiology, etiology, diagnostic challenges, management strategies, and outcomes associated with PPCM. A case report of a 29-year-old woman with PPCM is presented, emphasizing the importance of early recognition and tailored management. The patient's presentation was marked by atypical symptoms, including dysuria, lumbar pain, persistent fever, and oral intake intolerance. Despite aggressive medical intervention, the patient experienced a tragic outcome, succumbing to cardiopulmonary arrest within 48 h of admission. This case underscores the challenges in diagnosing and managing PPCM, particularly when presenting with nonspecific symptoms and emphasizes the urgent need for improved diagnostic criteria and therapeutic interventions to mitigate adverse outcomes in affected individuals.

Is "Leptin Resistance" Another Key Resistance to Manage Type 2 Diabetes?

Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake promotes a low-grade inflammatory response, which leads to dysregulations in lipid storage and adipokine secretion. In turn, these entail alterations in leptin sensitivity, leptin transport across the blood-brain barrier and defects in post-receptor signaling. Furthermore, hypothalamic inflammation and endoplasmic reticulum stress may increase the expression of molecules which may disrupt leptin signaling. Abundant evidence has linked obesity and leptin resistance, which may precede or occur simultaneously to IR and DM2. Thus, leptin sensitivity may be a potential early therapeutic target that demands further preclinical and clinical research. Modulators of insulin sensitivity have been tested in animal models and small clinical trials with promising results, especially in combination with agents such as amylin and GLP-1 analogs, in particular, due to their central activity in the hypothalamus.

Efectos producidos por el sulfato férrico y el formocresol en el tejido pulpar de gatos / Effects of ferric sulphate and formocresol on pulp tissue in cats

Este es un estudio descriptivo que se realizó con el fin de evaluar y comparar histológicamente dos sustancias, el formocresol y el sulfato férrico (solución de Monsel), que tienen la cualidad de detener la hemorragia pulpar cuando se realiza una pulpotomía. Se seleccionó una muestra de 10 gatos, a los cuales se les realizó terapia pulpar en los dientes caninos: a los del lado derecho con formocresol y a los del lado izquierdo con sulfato férrico. Los dientes se evaluaron a los 15 ya los 45 días para apreciar los diferentes estados de inflamación pulpar que pudieran presentar.- Se pudo observar que el formocresol pasa de una etapa de inflamación aguda a una crónica, a diferencia del sulfato férrico que a los 15días causó inflamación crónica y a los 45 no provocó ninguna. Con el formocresol fueron más frecuentes las necrosis focales coronales. A corto plazo, 9 de 10 pulpas mostraron vitalidad apical, tanto con el formocresol como con el sulfato férrico. A largo plazo, 5 de 8 pulpas tratadas con formocresol tenían vitalidad apical; lo mismo ocurrió con el sulfato férrico...