Brain-derived neurotrophic factor serum and plasma levels in the treatment of acute schizophrenia with olanzapine or risperidone: 6-week prospective study.

Antipsychotics have been the mainstay of the treatment of schizophrenia, and their potential role in neuroprotection could be related to brain-derived neurotrophic factor (BDNF). So far different effects on both serum and plasma levels of BDNF were reported related to the various antipsychotic treatments. Aim of this study was to investigate the influence of olanzapine or risperidone on both plasma and serum levels of BDNF in patients with acute schizophrenia. For 50 participants with acute episode of schizophrenia both plasma and serum BDNF, along with the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression scale, were assessed pretreatment and post treatment - after 6 weeks of either risperidone or olanzapine. Results show that a weak correlation between pretreatment plasma and serum levels of BNDF was found no longer significant after 6 weeks of treatment. Antipsychotics, olanzapine and risperidone showed no significant effect on post treatment plasma and serum levels of BDNF. Pretreatment plasma level of BDNF and PANSS positive subscale were positively correlated. Post treatment serum level of BDNF and Clinical Global Impression were negatively correlated. In conclusion, plasma and serum BDNF levels could be different markers to some extent with regard to clinical symptoms, response to therapy and outcome. The interrelation between serum and plasma BDNF should be established in further studies.

Were today's professors good students? Case study of the Zagreb University School of Medicine.

AIM: To determine whether the medical school grades of today's professors at the Zagreb University School of Medicine could serve as the predictors of their subsequent academic success. METHODS: We performed a retrospective descriptive study of medical school grades of professors and/or assistant professors at the Zagreb University School of Medicine from 1990 to 2003. The professors were divided into four groups according to the course they taught: Basic Science, Clinical Non-Surgery, Clinical Surgery, and Public Health. In total, data for 297 professors were analyzed. RESULTS: Today's professors were above-average students. The analysis of grades of professors teaching different disciplines revealed that Basic Science professors were the best students, followed by Non-Surgery and Surgery professors, whereas Public Health professors were the worst. Grades that professors earned in Public Health courses were the highest, followed by grades in Non-Surgical and Surgical courses. The grades in Basic Science courses were the lowest. CONCLUSION: Professors at the Zagreb University School of Medicine were above-average students and their grades seem to be important predictors of future success in academic career. Among today's professors, Basic Science professors were the best students.

Is there grade inflation at medical schools? Case study of the Zagreb University School of Medicine.

AIM: To investigate if students' grades at the Zagreb University School of Medicine increased since the establishment of the School in 1917. METHODS: In this retrospective descriptive study, we analyzed student sex, the length of studying, average of all grades, and grades from 5 major courses--anatomy, physiology, pathology, internal medicine, and surgery. The passing grades at the Zagreb University range from 2 (sufficient) to 5 (excellent). We analyzed data for 2,861 students from 9 representative classes, enrolled in 1920, 1930, 1940, 1950, 1960, 1970, 1980, 1985, and 1990. RESULTS: The number of female students constantly increased up to 1970 and hereafter the female to male ratio remained stable, 60:40. The percentage of enrolled students who graduated from the School increased from 1920 to 1940 and from 1960 to 1985. Between 1940 and 1960, the percentage of students who graduated was lower than 50%. There was a continuous increase in grades during the investigated period (p<0.001), except for students enrolled in 1960, who had lower grades than those enrolled in 1950. Students who enrolled in 1990 also had lower grades than those enrolling in 1985. Grades from the individual courses mostly followed the increasing trend of total grades. CONCLUSION: There has been an increasing trend in grades at the Zagreb University School of Medicine since its establishment in 1917.

Zagreb University School of Medicine: students grades during war.

AIM: To investigate whether examination grades of the students at the Zagreb University School of Medicine changed during the 1991-1995 war in Croatia. METHODS: The retrospective descriptive study included examination grades from 5 major courses in the first 5 years of the medical studies: Anatomy (first year), Physiology (second year), Pathology (third year), Internal Medicine (fourth year), and Surgery (fifth year). We compared the war-period (1991-1995) with two control periods: before (1989-1990) and after the war (1996-2000). The passing grades at the Zagreb University range from 2 to 5, with 2 as the lowest and 5 as the highest grade. There were a total of 17,682 examinations from the 5 courses in the studied periods. RESULTS: Grades were higher in the pre-war and post-war periods than in the war period (p<0.001 for both comparisons). Grades in the individual courses followed the general trend, except for the surgery course, where grades during the war were better than in the control periods, and the physiology course, where continual worsening, irrespective of the war, was observed. CONCLUSION: Medical students obtained significantly lower grades in 5 major courses during the war than before or after it. Thus, it is reasonable to assume that different factors, some related and some unrelated to war, could have adversely influenced students performance.