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1.
Artigo em Inglês | MEDLINE | ID: mdl-38716720

RESUMO

PURPOSE OF REVIEW: Familial Hypercholesterolemia is associated with an increased risk of cardiovascular disease. The current international guidelines of the main scientific societies consider that all people with familial hypercholesterolemia have a high or very high cardiovascular risk. However, the occurrence of atherosclerotic cardiovascular disease is very heterogeneous in this population. Stratifying risk within people with familial hypercholesterolemia is essential to identify individuals who require intensive cholesterol-lowering therapies. RECENT FINDINGS: In the last year, several studies have been published focusing on the contribution of diabetes to familial hypercholesterolemia, the role of stroke, as a manifestation of atherosclerotic disease, and the external validation of the SAFEHEART risk equation in the English population diagnosed with Familial Hypercholesterolemia. SUMMARY: It is necessary the development of a tool that allows us to identify, in a simple, reproducible, and universal way, patients who may have a high risk of suffering a cardiovascular event and who are susceptible to more intensive treatments to reduce cholesterol levels.

2.
Curr Opin Lipidol ; 34(6): 272-277, 2023 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-37769168

RESUMO

PURPOSE OF REVIEW: Familial hypercholesterolemia is associated with an increased risk of cardiovascular disease. The current international guidelines of the main scientific societies consider that, all people with Familial Hypercholesterolemia have a high or very high cardiovascular risk. However, the occurrence of atherosclerotic cardiovascular disease is very heterogeneous in this population. Stratifying risk within people with familial hypercholesterolemia is essential to identify individuals who require intensive cholesterol-lowering therapies. RECENT FINDINGS: In the last year, several studies have been published focusing on the contribution of diabetes to Familial Hypercholesterolemia, the role of stroke, as a manifestation of atherosclerotic disease, and the external validation of the SAFEHEART risk equation in the English population diagnosed with Familial Hypercholesterolemia. SUMMARY: It is necessary the development of a tool that allows us to identify, in a simple, reproducible, and universal way, patients who may have a high risk of suffering a cardiovascular event and who are susceptible to more intensive treatments to reduce cholesterol levels.


Assuntos
Aterosclerose , Doenças Cardiovasculares , Hiperlipoproteinemia Tipo II , Humanos , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/epidemiologia , Fatores de Risco , Hiperlipoproteinemia Tipo II/epidemiologia , LDL-Colesterol , Aterosclerose/complicações , Aterosclerose/epidemiologia , Aterosclerose/diagnóstico , Fatores de Risco de Doenças Cardíacas
3.
Endocrinol Diabetes Nutr (Engl Ed) ; 68(7): 450-457, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34863409

RESUMO

BACKGROUND: Familial Hypercholesterolemia is the most frequent genetic cause of premature coronary heart disease. The delay in the diagnosis prevents the correct early treatment. There are no effective screening strategies at the national level that ensure a correct diagnosis. OBJECTIVE: To determine the capacity of a centralized laboratory for the diagnosis of Familial Hypercholesterolemia through the creation of a health program for population screening in the province of Huelva. METHOD: Active search of patients with primary hypercholesterolemia through the blood tests carried out in the reference laboratories with results of low-density lipoprotein cholesterol greater than 200 mg/dl and assessment in the Lipid Unit of Huelva to identify index cases, with subsequent family cascade screening. RESULTS: 37,440 laboratory tests with lipid profile were examined. After screening, 846 individuals were seen in the Lipid Unit, of which they were diagnosed according to criteria of the Dutch Lipid Clinic Network as possible 654 and probable/definitive 192 individuals, representing 1.74% and 0.51% of the general population examined respectively. CONCLUSIONS: The point prevalence of Familial Hypercholesterolemia in patients submitted to laboratory lipid profile tests was 1:195, higher compared to the prevalence of Familial Hypercholesterolemia in the general population (based on 1 in 200-300). The opportunistic search strategy of the index case through a laboratory alert and centralized screening is an efficient strategy to implement a national screening for the diagnosis of Familial Hypercholesterolemia.


Assuntos
Hiperlipoproteinemia Tipo II , LDL-Colesterol , Doença da Artéria Coronariana , Humanos , Hiperlipoproteinemia Tipo II/diagnóstico , Programas de Rastreamento , Prevalência , Espanha
4.
Reumatol. clín. (Barc.) ; 9(6): 376-378, nov.-dic. 2013. ilus
Artigo em Espanhol | IBECS | ID: ibc-116224

RESUMO

La polimialgia reumática es una enfermedad inflamatoria reumática que se caracteriza por dolor y rigidez bilateral que afecta principalmente a la musculatura proximal. Aparece sobre todo en personas por encima de los 50 años y se asocia a una velocidad de sedimentación globular elevada en la analítica. La enfermedad generalmente responde muy bien a dosis bajas de corticoides. A continuación, presentamos el caso de un varón de 80años que presentó un cuadro compatible con polimialgia reumática asociado a derrame pleuropericárdico que respondió rápidamente a corticoides, con rápida mejoría en la sintomatología y en los hallazgos de laboratorio. La polimialgia reumática es una enfermedad que se presenta con relativa frecuencia pero que raramente se asocia a derrame pleuropericárdico. Es importante tenerla en cuenta en el diagnóstico diferencial del derrame pericárdico en personas mayores de 50años por su buena respuesta a tratamiento (AU)


Polymyalgia rheumatica is an inflammatory rheumatic disease that presents with bilateral pain and stiffness affecting mainly proximal muscles. It affects individuals over 50 years of age and it is usually associated with a raised erythrocyte sedimentation rate. Classically, treatment with low-dose corticosteroids results in a dramatic improvement in both symptoms and laboratory findings. We report the case of an 80 years old patient presenting polymyalgia rheumatica coinciding with pleuropericardial effusion. The patient had a very good response to treatment with rapid improvement in the symptomatology and laboratory findings. Polymyalgia Rheumatica is a common disease but it is rarely associated to pleuropericardial effusion. It should be considered in the differential diagnostic in patients presenting with pericardial effusion over 50 of age years due to the good response to treatment (AU)


Assuntos
Humanos , Masculino , Idoso de 80 Anos ou mais , Polimialgia Reumática/complicações , Polimialgia Reumática/diagnóstico , Polimialgia Reumática/tratamento farmacológico , Derrame Pericárdico/complicações , Derrame Pericárdico/diagnóstico , Derrame Pleural/complicações , Derrame Pleural/diagnóstico , Corticosteroides/uso terapêutico , Polimialgia Reumática/fisiopatologia , Derrame Pleural/etiologia , Diagnóstico Diferencial , Radiografia Torácica/métodos , Radiografia Torácica , Tomografia Computadorizada de Emissão
5.
Reumatol Clin ; 9(6): 376-8, 2013.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-23453662

RESUMO

Polymyalgia rheumatica is an inflammatory rheumatic disease that presents with bilateral pain and stiffness affecting mainly proximal muscles. It affects individuals over 50 years of age and it is usually associated with a raised erythrocyte sedimentation rate. Classically, treatment with low-dose corticosteroids results in a dramatic improvement in both symptoms and laboratory findings. We report the case of an 80 years old patient presenting polymyalgia rheumatica coinciding with pleuropericardial effusion. The patient had a very good response to treatment with rapid improvement in the symptomatology and laboratory findings. Polymyalgia Rheumatica is a common disease but it is rarely associated to pleuropericardial effusion. It should be considered in the differential diagnostic in patients presenting with pericardial effusion over 50 of age years due to the good response to treatment.


Assuntos
Derrame Pericárdico/etiologia , Derrame Pleural/etiologia , Polimialgia Reumática/complicações , Idoso de 80 Anos ou mais , Humanos , Masculino
6.
Enferm Infecc Microbiol Clin ; 21(4): 193-5, 2003 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-12681131

RESUMO

INTRODUCTION: To describe the clinical and epidemiologic characteristics of hepatic involvement in a cohort of 109 patients with Q fever. RESULTS: Involvement of the liver alone was documented in 55% of cases. In 96% it was manifested as a febrile process without focal symptoms and hepatic cytolysis. There were no differences in epidemiologic characteristics between patients with hepatitis and those and without. CONCLUSION: Q fever should be included in the differential diagnosis of community-acquired febrile syndromes.


Assuntos
Hepatite/etiologia , Febre Q/complicações , Adolescente , Adulto , Anticorpos Antibacterianos/sangue , Coxiella burnetii/imunologia , Coxiella burnetii/isolamento & purificação , Feminino , Febre/etiologia , Hepatite/microbiologia , Hospitais Gerais/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Febre Q/diagnóstico , Estudos Retrospectivos , Espanha/epidemiologia
7.
Artigo em Es | IBECS | ID: ibc-21639

RESUMO

INTRODUCCIÓN. Describir las características clínicas y epidemiológicas de la hepatitis aislada en una cohorte de 109 pacientes con fiebre Q.RESULTADOS. La hepatitis aislada representó el 55 por ciento. En el 96 por ciento de los casos se manifestó como un cuadro febril sin síntomas focales y cistólisis hepática. No se ha encontrado ninguna diferencia en las características epidemiológicas entre los pacientes con y sin hepatitis. CONCLUSIÓN. Debería considerarse la fiebre Q en del diagnóstico diferencial de los síndromes febriles adquiridos en la comunidad (AU)


Assuntos
Pessoa de Meia-Idade , Adolescente , Adulto , Masculino , Feminino , Humanos , Espanha , Coxiella burnetii , Febre Q , Estudos Retrospectivos , Anticorpos Antibacterianos , Hepatite , Hospitais Gerais , Febre
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