[Clinical experience with heparinoid sodium pentosan polysulfate (SP54) in the treatment of cerebral ischemia]. / Klinische Erfahrungen mit dem Heparinoid Natrium-Pentosanpolysulphat (SP54) bei der Behandlung zerebraler Ischämien.

Fifty-five patients suffering from acute cerebral ischaemia were treated with pentosan polysulphate (SP54) intravenously and subsequently orally. The control group consisting of 35 patients received the infusion solution and vasodilator drugs. The statistically significant changes appearing following infusion of SP54 include the following parameters: haematocrit, blood viscosity and cholesterol concentrations. In individual cases the euglobulin lysis time was shortened within two hours after the beginning of the infusion. As demonstrated by the statistically reliable results in patients treated with SP54 the neurological symptoms improved significantly within the first two weeks after the onset of the disease compared to the control groups. Based on case reports, recommendations are given for the indication and contraindication of SP54 treatment in cerebral ischaemia.

Investigation of adaptive processes in child and adolescent swimmers. Acid-base parameters of swimmers and weight-lifters.

Acid-base parameters of adolescent swimmers (capacitive sport) and of adult weight-lifters (athletoid sport) were investigated before and after training in the submaximally trained phase of a year-round training period. In swimmers, training induced incompensated metabolic acidosis, which persisted at 10 min after the training. This acidosis showed no correlation to the blood lactate level. In weight-lifters, there was only a slight, compensated posttraining acidosis, which tended to decrease 10 min after the training. The weight-lifters had extremely high posttraining ammonia levels. It might be supposed that ammonia-genesis has a role in the compensation of exercise-induced acidosis in weight-lifters. The differences in acid-base status of swimmers and weight-lifters might be related to the different breathing mechanism needed for the two different sports.

Adaptive processes in child and adolescent swimmers. Blood coagulation and viscosity.

Multifactorial studies were performed in child and adolescent swimmers in the early period of training and in a submaximum state of training in the year's racing period. Blood coagulation, viscosity, acidity, protein metabolism, muscle enzymes, ions, haematologic, cardiac and endocrine parameters have been investigated. In the early period of training, physical exercise resulted in fibrinolysis, and a decrease in the fibrinogen and prothrombin levels and the platelet count. The same exercise in fully-trained organisms failed to produce such changes. Data concerning acidity, protein metabolism, muscle enzymes, ions, haematologic, cardiac and endocrine parameters will be published in subsequent papers.