RESUMO
Although clinical and epidemiological aspects of oral cancers (OC) are well-documented in the literature, there is a lack of evidence on the economic burden of OC. This study aims to provide a comprehensive systematic assessment on the economic burden of OC based on available evidence worldwide. A systematic review was conducted. The population was any individual, who were exposed to OC, considered here as lip (LC), oral cavity (OCC), or oropharynx (OPC) cancer. The outcome was information on direct (medical and non-medical) and indirect (productivity loss and early death) costs. The data sources included Scopus, Web of Science, Cochrane, BVS, and NHS EED. A search of grey literature (ISPOR and INAHTA proceedings) and a manual search in the reference lists of the included publications were performed (PROSPERO no. CRD42020172471). We identified 24 studies from 2001 to 2021, distributed by 15 countries, in 4 continents. In some developed western countries, the costs of LC, OCC, and OPC reached an average of Gross Domestic Product per capita of 18%, 75%, and 127%, respectively. Inpatient costs for OC and LC were 968% and 384% higher than those for outpatients, respectively. Advanced cancer staging was more costly (from ~22% to 373%) than the early cancer staging. The economic burden of oral cancer is substantial, though underestimated.
Assuntos
Neoplasias Labiais , Neoplasias Bucais , Humanos , Neoplasias Bucais/epidemiologiaRESUMO
O presente estudo teve como objetivo analisar o desempenho aeróbio de sujeitos submetidos a um programa de treinamento intermitente máximo de curta duração. Para tal catorze sujeitos realizaram uma bateria de testes e passaram por um programa de treinamento intermitente máximo de curta duração durante oito semanas. A bateria de testes consistiu de determinação do limiar ventilatório e do VO2pico com o auxílio do analisador de gases VO2000 realizado em um cicloergômetro mecânico. A fim de comparar o comportamento das variáveis foi utilizado o teste t de student para amostras pareadas, utilizando como nível de significância p≤0,05. Por meio da análise dos dados foi possível verificar que estímulos anaeróbios intensos também foram capazes de provocar modificações na condição aeróbia como pode ser observado na melhora do consumo de oxigênio de pico e na eficiência do músculo cardíaco, indicado pelo comportamento do duplo produto, dos sujeitos submetidos ao programa de treinamento.
The aim of this study was to analyze the aerobic performance of individuals who were submitted to a program of maximum intermittent training of short duration. For such investigation, fourteen subjects performed a set of tests, accomplishing a program of maximum intermittent training of short duration for eight weeks. Those tests consisted of the determination of the ventilatory threshold and the VO2max, using the gas analyzer VO2000. In order to compare the status of the variables, it was applied the student t test for paired samples, using p<0,05 as the significance level. By means of the data analysis, it was possible to verify that intense anaerobic stimulus could also provoke modifications in the aerobic condition, as it was observed in the improvement of the peak oxygen consumption and in the efficiency of the cardiac muscle, indicated by the behavior of the double product, of the individuals who were submitted to the training program.
