Micro-structured Beta-Tricalcium Phosphate for Repair of the Alveolar Cleft in Cleft Lip and Palate Patients: A Pilot Study.

OBJECTIVES: Can a synthetic bone substitute be used to repair the alveolar cleft to bypass donor site morbidity as well as to shorten the operating time? In earlier experimental studies, micro-structured beta-tricalcium phosphate (ß-TCP) provided similar bone healing when compared with grafting with iliac crest bone. This justifies the clinical evaluation of this bone substitute in the human alveolar cleft situation. DESIGN: Prospective clinical study. SETTING: University clinic. PARTICIPANTS: Seven patients, all with unilateral alveolar cleft, were randomly included for alveolar cleft repair with ß-TCP in 2010 and 2011. MAIN OUTCOME MEASURES: In all patients, the alveolar cleft was repaired by micro-structured ß-TCP grafting. Our assessments were distilled from cone beam computed tomography scans taken preoperatively, 1 week postoperatively, and 6 months postoperatively. A volumetric outcome could be realized. RESULTS: Six months after the operative grafting of micro-structured ß-TCP into the alveolar cleft, the bone volume thus acquired was satisfactory. We found an average bone volume percentage of 73% ± 6% compared with the original cleft volume. CONCLUSIONS: Previous experimental and clinical studies and the initial findings of this pilot study now elucidate a path toward the clinical use of micro-structured ß-TCP bone substitute for repair of the alveolar cleft.

The influence of mandibular advancement surgery on oral function in retrognathic patients: a 5-year follow-up study.

PURPOSE: Previous studies have shown that patients with mandibular retrognathism who were scheduled for orthognathic surgery have a lower maximum bite force and an impaired chewing performance. Surgical correction of this deformity is supposed to lead to an improvement of these oral functions. One year after surgery, no significant changes could be shown in these patients. However, a longer follow-up might demonstrate an improvement after all. PATIENTS AND METHODS: Maximum bite force and chewing performance were determined in 12 patients with a mandibular retrognathism before mandibular advancement surgery and at least 5 years after surgery. Chewing performance (median particle size) was determined with a sieving method after chewing 15 strokes on an artificial test food. Maximum bite force was recorded bilaterally at the level of the first molars. RESULTS: Five years after surgery, chewing performance was improved, especially in patients with a poor performance before treatment. An increase of the maximum bite force could not be shown. CONCLUSION: Surgical correction of mandibular retrognathism had a positive effect on oral function 5 years after surgery, although it could not be detected 1 year after surgery. However, the function of the masticatory system was still impaired when compared with controls.