Loss of engagement in controlling chronic anticoagulation therapy during Covid-19 stringency measures. A single center experience of disproportioned increase of stuck mechanical valves.

Stuck valve is a very rare and severe complication that occurs in mechanical valve replacement patients with ineffective anticoagulation. However, with COVID-19 restriction measures, it became challenging to regularly assess INR to make sure it falls within the target therapeutic range to prevent this complication. We present a series of 10 patients who either underwent transthoracic echocardiography for a suspected stuck valve or were seen at the outpatient valve clinic with the residual consequences of a stuck valve during the COVID-19 restriction measures in our institute. Stuck prosthetic valves incident has increased significantly during this period, particularly those in the mitral position for which urgent replacement and prolonged hospitalization were necessary. Particularly with the COVID-19 restrictions in place, these cases highlight the need for physicians to be aware of the dramatic increase in the incidence of stuck prosthetic valves in patients on chronic warfarin therapy.

The trade-off between costs and outcome after cardiac surgery. Evidence from an Italian administrative registry.

Effective resource allocation policies relating to the long-term effects of complex surgical procedures require accurate prediction of the likelihood of future hospitalization. By approximating clinical conditions with administrative data and controlling for complex case-mix scenarios, we provide evidence of a trade-off between costs and outcome in cardiac surgery. We modelled administrative data to account for clinical conditions in a population of patients admitted for cardiac surgery and their readmissions for complications. Costs were calculated at first admission, the outcome variable was defined as time to readmission within six months post-discharge. Risk factors for readmission were defined as comorbidities and postoperative complications, derived by clinical judgement from the International Classification of Diseases. We predicted health outcome as a function of costs and other patient- and hospital-level features using a two-stage residual inclusion estimation method to tackle endogenous relationships applied to Cox proportional hazard models. We confirmed the trade-off and negative association between costs and hazard of readmission when controlling for all complex risk factors. Accurate matching of standard codes for diseases and procedures with clinical conditions may be a reliable methodology to assess time to readmissions and costs on a large population scale.