1.
Bioorg Med Chem Lett
; 20(17): 5133-8, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20673630
RESUMO
Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ's) was identified by high throughput screening. The optimization of these hits to provide a lead series is described.