1.
Bioorg Med Chem Lett
; 19(21): 5999-6003, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19800790
RESUMO
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the delta receptor, increased selectivity versus mu and kappa as well as improved in vitro metabolic stability.