RESUMO
PURPOSE: External-beam radiotherapy (EBRT) is the predominant method for localized brain radiotherapy (LBRT) after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50-kV xrays is an alternative way to focally irradiate the resection cavity after BM surgery, with the option of shortening the overall treatment time and limiting normal tissue irradiation. METHODS: We retrospectively analyzed the outcomes of all patients who underwent neurosurgical resection of BM and 50-kV xray IORT between 2013 and 2020â¯at Augsburg University Medical Center. RESULTS: We identified 40 patients with 44 resected BM treated with 50-kV xray IORT. Median diameter of the resected metastases was 2.8â¯cm (range 1.5-5.9â¯cm). Median applied dose was 20â¯Gy. All patients received standardized follow-up (FU) including 3monthly MRI of the brain. Mean FU was 14.4 months, with a median MRI FU for alive patients of 12.2 months. Median overall survival (OS) of all treated patients was 26.4 months (estimated 1year OS 61.6%). The observed local control (LC) rate of the resection cavity was 88.6% (estimated 1year LC 84.3%). Distant brain control (DC) was 47.5% (estimated 1year DC 33.5%). Only 25% of all patients needed WBI in the further course of disease. The observed radionecrosis rate was 2.5%. CONCLUSION: IORT with 50-kV xrays is a safe and appealing way to apply LBRT after neurosurgical resection of BM, with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early.
