1.
Bioorg Med Chem Lett
; 14(17): 4439-43, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15357968
RESUMO
Synthesis of a new family of quinolylhydrazone derivatives and evaluation of their activity against a chloroquine-resistant strain of Plasmodium falciparum are described. The best compound displayed an activity 6-fold higher than chloroquine. None of the active compounds were found to inhibit beta-hematin formation in vitro in the same range as chloroquine and five among them displayed lower calculated vacuolar accumulation ratios, suggesting the implication of a different mechanism of action.