Different Safety Pattern of an Inactivated SARS-CoV-2 Vaccine (CoronaVac®) According to Age Group in a Pediatric Population from 3 to 17 Years Old, in an Open-Label Study in Chile.

During the COVID-19 pandemic, the importance of vaccinating children against SARS-CoV-2 was rapidly established. This study describes the safety of CoronaVac® in children and adolescents between 3- and 17-years-old in a multicenter study in Chile with two vaccine doses in a 4-week interval. For all participants, immediate adverse events (AEs), serious AEs (SAEs), and AEs of special interest (AESIs) were registered throughout the study. In the safety subgroup, AEs were recorded 28 days after each dose. COVID-19 surveillance was performed throughout the study. A total of 1139 individuals received the first and 1102 the second dose of CoronaVac®; 835 were in the safety subgroup. The first dose showed the highest number of AEs: up to 22.2% of participants reported any local and 17.1% systemic AE. AEs were more frequent in adolescents after the first dose, were transient, and mainly mild. Pain at the inoculation site was the most frequent AE for all ages. Fever was the most frequent systemic AE for 3-5 years old and headache in 6-17 years old. No SAEs or AESIs related to vaccination occurred. Most of the COVID-19 cases were mild and managed as outpatients. CoronaVac® was safe and well tolerated in children and adolescents, with different safety patterns according to age.

Giardiasis en jardines infantiles: tratamiento simultáneo de casos y contactos / Giardiasis day-care centers: simultaneous treatment of cases and contacts

Se compara el rendimiento obtenido mediante tratamiento con metronidazol para control de la Giardiasis en niños de 3 jardines, infantiles de Santiago. El estudio coproparasitológico seriado (3 muestras), según método de Burrows, realizado en 230 niños y 23 funcionarios auxiliares de esos establecimientos, mostró infección por G. lamblia en 42,6% de los niños y 21,7% de los adultos, sin diferencias significativas entre los 3 centros. En uno de ellos se trató simultáneamente a todos los niños y al personal infectado; en otro se procedió de igual manera incluyendo además a todos los familiares de los niños infectados y el tercero se dejó como control, sin aplicar tratamiento por el momento. Dos, cuatro y seis meses después del tratamiento se repitieron los exámenes coproparasitológicos de toda la población estudiada, comprobándose resultados significativamente mejores y más duraderos en el grupo donde se trataron todos los contactos