[Reaferon and interferonogenes in the therapy of acute viral hepatitis B]. / Primenenie reaferona i interferonogenov v terapii ostrogo virusnogo gepatita B.

Monotherapy with reaferon (alpha 2-interferon) versus prodigiosan plus ibuprofen combination was investigated in acute viral hepatitis B. The drugs were found to stimulate cellular immunity and to induce a decrease of total serum IgE levels. The effect of prodigiosan combined with ibuprofen proved more pronounced.

[Immediate hypersensitivity reaction in acute viral hepatitis A and B treated with interferon inducers]. / Reaktsii nemedlennoi allergii pri ostrykh virusnykh gepatitakh A i B pri lechenii induktorami interferonoobrazovaniia.

The therapeutic effects of prodigiozan and ibuprofen, endogenous interferon production inductors, were studied in the patients with acute viral hepatitides A and B with consideration for the body allergic reactivity at the peak of the disease. The results evidence a favourable effect of these drugs on the clinical course of the disease and on liver function; immuno- and interferon-stimulating and desensitizing effects manifested mainly in hepatitis A cases with immediate types II and III hypersensitivity and in hepatitis B cases with immediate types I and II hypersensitivity.

[Use of interferon inducers and reaferon in the combined therapy of acute viral hepatitis B]. / Primenenie interferonogenov i reaferona v kompleksnoi terapii ostrogo virusnogo gepatita B.

The therapeutic effectiveness of interferon inducers (prodigiozan and ibuprofen), the Soviet drug reaferon and their combined use in acute viral hepatitis type B was studied. Indications for their use resulted from lowered capacity of the body for interferonogenesis at the height of the disease. The above drugs stimulated cellular immunity, promoted more rapid disappearance of clinical symptoms of disease, and reduced the period of hospital treatment. A more marked therapeutic effect was noted in combined administration of reaferon and ibuprofen.

[Indices of immunity and allergy in patients with viral hepatitis treated with prodigiozan]. / Nekotorye pokazateli immuniteta i allergii u bol'nykh virusnymi gepatitami pri lechenii prodigiozanom.

The immune and allergic status of patients with acute viral hepatitides A and B after treatment with prodigiosan, a bacterial lipopolysaccharide preparation, was studied. The drug produced as stimulating effect on cell-mediated and humoral immunity. The development of delayed specific drug sensitization was registered in two-thirds of the patients, which correlated with the regression of clinicobiochemical manifestations of hepatitis.