The Antecedents of the Technology Acceptance Model in Microentrepreneurs' Intention to Use Social Networking Sites.

Social media platforms offer significant growth opportunities for enterprises, particularly microenterprises, due to the chance to establish direct contact with customers. Drawing on the Technology-Acceptance Model (TAM), in the present study, we investigate the psychological reasons that lead microentrepreneurs to use Social Networking Sites (SNSs) for their business. In doing so, we also extend TAM by taking into account entrepreneurs' personalities (e.g., extraversion and openness to experience) and their perceived risk. We collected data by examining 247 microentrepreneurs engaged in the production of handmade objects. Our results confirm that of all the TAM behavioral antecedents tested, perceived usefulness and attitude toward SNSs' usage for business proved to be the best predictors of the intention to use SNSs for business activity. The results also indicate that extraversion, openness to experience, and perceived risk, as external factors, significantly affect the TAM constructs. We discuss implications and suggestions for future research.

Fake News and the Sleeper Effect in Social Media Posts: the Case of Perception of Safety in the Workplace.

Fake news and misinformation on social media platforms are two of the biggest problems of the last few years. Understanding the underlying mechanisms of memory is of fundamental importance to develop specific intervention programs. In this study, 324 white-collar workers viewed Facebook posts focused on coronavirus disease-2019 prevention norms in the workplace. In a within-participants design, we manipulated the message and the source to expose each participant to real news, real news presented by a discounting cue (sleeper effect condition), and fake news. The results show that participants were more susceptible to fake news during a 1-week delayed posttest following a memory recall process. Furthermore, they remembered the message easily, but not the source, which did not differ in the real-news conditions. We discuss the results, mentioning the sleeper effect and fake news theories.

Interplay Between Fear of Missing Out and Loneliness: A Three-Wave Panel Study During the COVID-19 Pandemic.

Although the concept of Fear of Missing Out (FoMO) is permeated with individual fears about the lack of social connection, the relationship between FoMO and feelings of loneliness has been the subject of limited research. The aim of this study was to examine bidirectional associations between FoMO and loneliness via a three-wave, random intercept, cross-lagged panel model. Drawing on a survey with 494 adult participants across three waves (45.3 percent participated in Time 2 and 38.7 percent participated at Time 3) during the COVID-19 pandemic, we found that participants with higher FoMO also reported heightened levels of loneliness across the three waves, at a between-person level. Furthermore, loneliness had significant negative cross-lagged associations with subsequent FoMO, at within-person level. The cross-lagged paths between FoMO and subsequent loneliness were not significant. Participants who usually spend more daily time using social media reported higher levels of FoMO. The findings of the study contribute to clarifying the temporal relationship between FoMO and loneliness, by suggesting that FoMO may not represent a risk factor for heightened feelings of loneliness, but it can be triggered by feelings of social isolation and lack of relationships.

Entrepreneurship on Social Networking Sites: The Roles of Attitude and Perceived Usefulness.

BACKGROUND: Social media platforms are a significant growth opportunity for enterprises, especially for microenterprises, due to the possibility of establishing direct contact with their customers. We investigate the psychological reasons that drive entrepreneurs towards the use of social networking sites (SNSs) for their business, following two important social psychology theories: the theory of planned behaviour and the technology acceptance model. We also tested for two personality traits: openness to experience and dominance. METHODS: Data were acquired by examining 325 microentrepreneurs who decided to use either SNSs or traditional sales methods for their businesses. RESULTS AND CONCLUSIONS: Our results confirm that of all the behavioural antecedents tested, perceived usefulness and attitude towards SNSs' effect on business proved to be the best predictors of the intention to use (or continue using) SNSs for business activity. Implications and suggestions for future research are also discussed.

The role of sexting in couple wellbeing for Italian women during the second wave of the COVID-19 pandemic.

The social isolation due to the COVID-19 pandemic had an impact on the sexuality and quality of life of people around the world. A particularly negative effect was detected on women's sexual health. As a consequence, many women began to use social media not only to stay in touch with their social networks, but as a way of maintaining sexual contact. The main aim of this research is to observe the positive effects of sexting in women's wellbeing as a strategy to manage the negative effects of a condition of forced isolation. We collected all our data between November 2020 and March 2021 during a period of strict restrictions in Italy due to the second wave of the COVID-19 pandemic. In Study 1, the relationship between loneliness, sexting behaviors, and sexual satisfaction was tested on 312 adult women. The results showed the mediator role of motivation for sexting in the relationship between loneliness and sexual satisfaction. In Study 2, 342 adult women were organized into two groups (women who had sexting at least once during the second wave of the pandemic = 203, and women who did not have sexting during the pandemic = 139) and were assessed on a couple's wellbeing (intimacy, passion, commitment, and couple satisfaction) and electronic surveillance. The results show that women who had sexting during isolation had higher scores on intimacy, passion, couple satisfaction, and electronic surveillance. These findings suggest the important role of sexting as an adaptive coping strategy during particular conditions of social isolation.

Interaction through social media: Development and validation of a social network site self-efficacy scale (SNS-SES).

Today, more than ever before, awareness of our ability to interact with others through and use social network sites (SNSs) is of fundamental importance, in light of the fact that we are connected to the Web 24 h a day, 7 days a week. Studies of social media in recent decades have shown that self-efficacy is one of the key variables affecting individual online behavior. The general aim of the studies presented here was to develop and validate a new self-report scale measuring self-efficacy in SNS use (an SNS self-efficacy scale, or SNS-SES). Across two studies, a total of 1295 Italian adolescents and adults (ages 15 to 89; M = 38.21, SD = 15.6) participated. The SNS-SES consists of 24 items assessing four factors of self-efficacy in SNS use: task-oriented/technological, task-oriented/social, interpersonal, and emotional. Exploratory and confirmatory factor analyses showed a clear factorial validity of this stable four-factor solution.

The Role of Trust in Disaster Risk Reduction: A Critical Review.

In recent years, there has been a growing interest in the concept of trust within the domain of natural disaster management. Trust can be defined as a state of vulnerability where one party relies on another party with the expectation that the latter will carry out entrusted responsibilities without exploiting this inherent vulnerability. This comprehensive literature review is dedicated to the examination of research concerning community and institutional trust in the field of disaster risk reduction (DRR). Particular emphasis is placed on elucidating the influence of trust throughout the distinct phases of natural disaster management, namely prevention, preparedness, response, and recovery. The critical examination of the pertinent body of the literature demonstrates that trust plays a central role across the different phases of DRR, being positively associated with effective community responses and resilience. Hence, it becomes imperative to actively foster the development of trust at both institutional and community levels within the realm of DRR. This endeavor is essential for adequately preparing communities to confront natural disasters, crafting effective protocols to enhance community responsiveness and mitigate adverse consequences, and advancing strategies for successful reconstruction and recovery.

Gambling Disorders Among Young Women Regular Gamblers: The Unique and Common Contribution of Executive Thinking Style and Mindfulness.

The aim of this study is to investigate the role played by mindfulness in the relationship between cognitive styles and gambling disorders in a sample of female young adults. Participants in this study (125 women; Mage = 18.64 years; SD = 1.7) were recruited in betting or bingo halls. They completed the South Oaks Gambling Screen, the Child and Adolescent Mindfulness Measure, and Sternberg's questionnaire on thinking styles. The results from the mediation analyses revealed that the executive thinking style increases gambling and that the deficit in mindfulness ability mediates this relationship. Theoretical and clinical implications are discussed.

Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders.

Increasing evidence indicates lithium (Li+) efficacy in neuropsychiatry, pointing to overlapping mechanisms that occur within distinct neuronal populations. In fact, the same pathway depending on which circuitry operates may fall in the psychiatric and/or neurological domains. Li+ restores both neurotransmission and brain structure unveiling that psychiatric and neurological disorders share common dysfunctional molecular and morphological mechanisms, which may involve distinct brain circuitries. Here an overview is provided concerning the therapeutic/neuroprotective effects of Li+ in different neuropsychiatric disorders to highlight common molecular mechanisms through which Li+ produces its mood-stabilizing effects and to what extent these overlap with plasticity in distinct brain circuitries. Li+ mood-stabilizing effects are evident in typical bipolar disorder (BD) characterized by a cyclic course of mania or hypomania followed by depressive episodes, while its efficacy is weaker in the opposite pattern. We focus here on neural adaptations that may underlie psychostimulant-induced psychotic development and to dissect, through the sensitization process, which features are shared in BD and other psychiatric disorders, including schizophrenia. The multiple functions of Li+ highlighted here prove its exceptional pharmacology, which may help to elucidate its mechanisms of action. These may serve as a guide toward a multi-drug strategy. We propose that the onset of sensitization in a specific BD subtype may predict the therapeutic efficacy of Li+. This model may help to infer in BD which molecular mechanisms are relevant to the therapeutic efficacy of Li+.

An attempt to dissect a peripheral marker based on cell pathology in Parkinson's disease.

Peripheral markers in Parkinson's disease (PD) represent a hot issue to provide early diagnosis and assess disease progression. The gold standard marker of PD should feature the same reliability as the pathogenic alteration, which produces the disease itself. PD is foremost a movement disorder produced by a loss of nigrostriatal dopamine innervation, in which striatal dopamine terminals are always markedly reduced in PD patients to an extent, which never overlaps with controls. Similarly, a reliable marker of PD should possess such a non-overlapping feature when compared with controls. In the present study, we provide a novel pathological hallmark, the autophagosome, which in each PD patient was always suppressed compared with each control subject. Autophagosomes were counted as microtubule-associated proteins 1A/1B light chain 3B (LC3)-positive vacuoles at ultrastructural morphometry within peripheral (blood) blood mononuclear cells (PBMC). This also provides the gold standard to assess the autophagy status. Since autophagy may play a role in the pathogenesis of PD, autophagosomes may be a disease marker, while participating in the biology of the disease. Stoichiometric measurement of α-synuclein despite significantly increased in PD patients, overlapped between PD and control patients. Although the study need to be validated in large populations, the number of autophagy vacuoles is neither related with therapy (the amount was similarly suppressed in a few de novo patients), nor the age in PD or controls.

The role of online social comparison as a protective factor for psychological wellbeing: A longitudinal study during the COVID-19 quarantine.

During the COVID-19 pandemic crisis, the experience of quarantine has been an undesirable condition for people and it can have a negative impact on mental health and psychological wellbeing. Social isolation has led to an increase in time spent on social network sites, with people interacting more frequently with each other, and comparing online the way in which they are experiencing the same state of home confinement. Our study aimed to investigate the role of online social comparison on individuals' psychological distress and life satisfaction during the COVID-19-related quarantine. Specifically, a cross-lagged panel study at three-waves was conducted in Italy in order to examine the change in psychosocial distress levels (e.g. depression, anxiety, stress, loneliness, low life-satisfaction) from before the quarantine for a period of one month, as well as the predictive role of online social comparison to ameliorate individual distress. An online survey was distributed through a social media platform three times after the initial lockdown and at the epidemic's peak two and five weeks later. A total of 113 participants participated in an online survey between the 7th of March and 14th of April 2020. The results showed an increase in the levels of loneliness, depression, stress, anxiety and a decrease in the level of life satisfaction in the pre/post quarantine comparison. Our cross-lagged results also showed that online social comparison at T1 and T2 predicted the individual's improvement in levels of anxiety, stress, loneliness and life satisfaction over time. Overall, the results of the current study underline the positive effects of online social comparison on the reduction of psychological distress during the COVID-19 quarantine.

The Role of Narcissism, Hyper-competitiveness and Maladaptive Coping Strategies on Male Adolescent Regular Gamblers: Two Mediation Models.

The present study aimed to explore the unique and common role that some cognitive, personality and relational characteristics play in male adolescents' regular gambling behavior. Participants were 273 male adolescents and young adults aged 15-19 recruited in sports betting centers. They completed the South Oaks Gambling Screen, the Narcissistic Admiration and Rivalry Questionnaire, the Hypercompetitive Attitude scale, and The Coping Strategy Indicator. The relationship between narcissistic rivalry and gambling was mediated by hyper-competitiveness and avoidant coping strategy. These findings suggest that narcissistic features and maladaptive coping strategies might be involved in the development of disordered gambling in youth, supporting a compensatory model of this addictive behavior and claiming for preventative actions that take into account the psychological vulnerabilities of adolescents and young adults.

Comparing the emerging psychological meaning of tattoos in drug-addicted and not drug-addicted adults: A look inside health risks.

Although tattoos have been historically characteristic of criminals and drug addicts therefore carrying negative associations, it is now an accepted and appreciated form of body modification. Tattoos could be considered as a projective psychological test, most people use their body as blackboard to represent the most varied meanings related to the way they perceive themselves. It is also true that tattoos can assume the role of diagnostic indicators for a possible abuse of psychoactive substances, as well as their aggregating and communicative functions within the group of drug addicts. The aim of this cross-sectional study was to explore the relation among personality traits, self-efficacy, locus of control and motivations for tattooing. The sample consisted of 150 subjects, 50 tattooed adults, 50 tattooed drug addicted adults, and 50 non-tattooed adults. Data were collected by using the Big Five Questionnaire (BFQ), the Perceived Self- efficacy Test, the Mini Locus of Control scale and a Tattoos Inventory. Results of the present study contribute to a deeper understanding of the new meaning of tattoos, they no longer represent personality traits, they rather have the function of reinforcing beliefs about how to perceive oneself, this happens especially in drug addicts in which the presence of tattoos reinforces the illusory belief of self-esteem and internal locus of control. Given the rising presence of tattoos today, this could be useful to get a better understanding of the existential unease of certain populations.

Coping Strategies, Creativity, Social Self-Efficacy, and Hypercompetitiveness in Gambling Behaviors: A Study on Male Adolescent Regular Gamblers.

The purpose of this research was to explore the cognitive and personality characteristics of male adolescent gamblers. Participants were 273 teenage males (M = 18.04, SD = 2.10) attending betting centers in Sicily, who completed self-report questionnaires on gambling, creativity, perceived social self-efficacy, hypercompetitiveness, and coping strategies. Pathological gamblers reported higher levels of avoidant coping strategies than occasional gamblers. They also scored higher on hypercompetitiveness than both occasional and problem gamblers. Further, problem gamblers scored higher than occasional gamblers on the complexity domain of creative personality. Finally, poor perceived social self-efficacy, higher levels of avoidant coping, and hypercompetitiveness predicted pathological gambling. Theoretical, psycho-educational, and clinical implications are discussed.

Problematic Facebook use and anxiety concerning use of social media in mothers and their offspring: An actor-partner interdependence model.

Previous research has shown significant and positive associations between social anxiety of parents and their adolescent offspring. The main aim of this study was to investigate this relationship in the social media (SM) context. We tested one hundred and fifty-two couples comprising mothers and their adolescent offspring (12-14 years old) on their levels of problematic Facebook use (PFU) and social anxiety concerning SM use. An actor-partner interdependence model highlighted the positive relationship between the PFU scores of mothers and their offspring on the levels of SM social anxiety in the offspring. We discuss the results in the context of intergenerational transfer of problematic technology use and social anxiety.

Erratum to "Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease".

[This corrects the article DOI: 10.1155/2018/5651435.].

Heterozygous PLA2G6 Mutation Leads to Iron Accumulation Within Basal Ganglia and Parkinson's Disease.

Mutations of PLA2G6 gene are responsible for PARK14, an autosomal recessive L-DOPA responsive dystonia/parkinsonism with early/adult onset. This phenotype possesses an high clinical variability, which consists in the occurrence of cerebral and cerebellar atrophy, iron accumulation in the basal ganglia, and cognitive decline. This report describes a PD patient carrying an heterozygous PLA2G6 mutation, which was identified also in his PD affected sister. This patient is characterized by a L-DOPA responsive typical parkinsonian syndrome without the occurrence of dystonia, a slight cognitive decline, presence of iron accumulation both in neo and paleostriatum while cerebellar atrophy was absent. Clinical and imaging features are compatible with the PARK14 phenotype. Although PARK14 has been previously reported to be inherited as a recessive disorder, clinical and genetic analysis of this proband and his family rise the hypothesis that even heterozygous PLA2G6 mutations may cause PARK14. It remains to be analyzed whether these heterozygous variants may act as dominant mutations, or they merely increase the risk to develop PD by acting within a context of synergistic genetic and/or environmental backgrounds.

Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease.

Deletion at 22q11.2 responsible for Di George syndrome (DGs) is a risk factor for early-onset Parkinson's disease (EOPD). To date, all patients reported with 22q11.2 deletions and parkinsonian features are negative for a family history of PD, and possible mutations in PD-related genes were not properly evaluated. The goal of this paper was to identify variants in PD genes that could contribute, together with 22q11.2 del, to the onset of parkinsonian features in patients affected by Di George syndrome. To this aim, sequencing analysis of 4800 genes including 17 PD-related genes was performed in a patient affected by DGs and EOPD. The analysis identified mutation p.Gly399Ser in OMI/HTRA2 (PARK13). To date, the mechanism that links DGs with parkinsonian features is poorly understood. The identification of a mutation in a PARK gene suggests that variants in PD-related genes, or in genes still not associated with PD, could contribute, together with deletion at 22q11.2, to the EOPD in patients affected by DGs. Further genetic analyses in a large number of patients are strongly required to understand this mechanism and to establish the pathogenetic role of p.Gly399Ser in OMI/HTRA2.

Revisiting the gamma loop in ALS.

Amyotrophic Lateral Sclerosis (ALS) is a fast progressive neurodegenerative disease characterized by muscle denervation, weakening and atrophy, which eventually culminates into death, mainly due to respiratory failure. The traditional view of ALS as a disorder affecting selectively motor neurons throughout the central nervous system has been progressively dispelled by innumerous lines of evidence indicating that other cells but motor neurons may be affected as well. Remarkably, this disorder is not limited to the motor system but rather configures as a systemic disease yielding a plethora of clinical signs. Among this broad clinical spectrum, sensory neuropathy occurring parallel to motor dysfunction is a quite frequent feature within ALS patients, which has spurred the interest of many investigators during the years. In line with this, morphological studies have confirmed that sensory neurons and axons' degeneration may occur in both ALS- experimental models and -patients. Noteworthy, this may have a nonetheless negligible role in ALS -related motor decline, as highlighted by recent studies showing that, degeneration of type I/II proprioceptive fibers is a primary source of alpha-motor neurons' death. These latter in fact, differently from gamma motor neurons, are a direct monosynaptic target of proprioceptive fibers. The present findings contribute to define a novel scenario of sensorimotor ALS pathophysiology where the gamma loop's fine connectivity may play a key role. In support to this view, in the present manuscript we provide a reappraisal on the role of single gamma loop's components in ALS.

Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of Disease.

Mammalian retromers play a critical role in protein trans-membrane sorting from endosome to the trans-Golgi network (TGN). Recently, retromer alterations have been related to the onset of Parkinson's Disease (PD) since the variant p.Asp620Asn in VPS35 (Vacuolar Protein Sorting 35) was identified as a cause of late onset PD. This variant causes a primary defect in endosomal trafficking and retromers formation. Other mutations in VPS genes have been reported in both sporadic and familial PD. These mutations are less defined. Understanding the specific prevalence of all VPS gene mutations is key to understand the relevance of retromers impairment in the onset of PD. A number of PD-related mutations despite affecting different biochemical systems (autophagy, mitophagy, proteasome, endosomes, protein folding), all converge in producing an impairment in cell clearance. This may explain how genetic predispositions to PD may derive from slightly deleterious VPS mutations when combined with environmental agents overwhelming the clearance of the cell. This manuscript reviews genetic data produced in the last 5 years to re-define the actual prevalence of VPS gene mutations in the onset of PD. The prevalence of p.Asp620Asn mutation in VPS35 is 0.286 of familial PD. This increases up to 0.548 when considering mutations affecting all VPS genes. This configures mutations in VPS genes as the second most frequent autosomal dominant PD genotype. This high prevalence, joined with increased awareness of the role played by retromers in the neurobiology of PD, suggests environmentally-induced VPS alterations as crucial in the genesis of PD.