La asociación entre Fusobacterium nucleatum y el cáncer colorrectal: una revisión sistemática y metaanálisis / The association between Fusobacterium nucleatum and cancer colorectal: a systematic review and meta-analysis

IntroducciónSe desconocen los factores etiológicos exactos del cáncer colorrectal (CCR), aunque se ha intentado relacionar con factores genéticos y ambientales. La posible asociación con Fusobacterium nucleatum podría abrir posibilidades en el diagnóstico precoz.ObjetivoRevisar los estudios que analizan la asociación entre F. nucleatum y el CCR.MétodosSe utilizaron las publicaciones disponibles en la base de datos MEDLINE PubMed hasta el día 1 de enero de 2020, que incluían los términos «cáncer colorrectal» y «Fusobacterium nucleatum». Se realizó un metaanálisis con el software Stata.ResultadosUn total de 57 artículos fueron incluidos en la revisión sistemática. El metaanálisis indicó una mayor presencia de F. nucleatum en muestras de tejido tumoral de CCR, con respecto a muestras control de tejido sano, con una odds ratio de 4,558 (IC 95%: 3,312-6,272), y cuando se utilizaron muestras control de adenomas colorrectales, con una odds ratio de 3,244 (IC 95%: 2,359-4,462).ConclusiónHay una mayor presencia de F. nucleatum en el CCR. Sin embargo, se necesitan estudios que demuestren esta relación.

IntroductionThe etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.ObjectiveTo review studies that address the association between F. nucleatum and CRC.MethodsThe MEDLINE PubMed database was searched using the terms «colorectal cancer» and «Fusobacterium nucleatum», retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.ResultsThe systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumor tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95% CI: 2.359-4.462).ConclusionThere is a more frequent presence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.

The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis.

INTRODUCTION: The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis. OBJECTIVE: To review studies that address the association between F. nucleatum and CRC. METHODS: The MEDLINE PubMed database was searched using the terms «colorectal cancer¼ and "Fusobacterium nucleatum", retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis. RESULTS: The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumour tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95 % CI: 2.359-4.462). CONCLUSION: There is a more frequent resence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.

The association between Fusobacterium nucleatum and cancer colorectal: a systematic review and meta-analysis. / La asociación entre Fusobacterium nucleatum y el cáncer colorrectal: una revisión sistemática y metaanálisis.

INTRODUCTION: The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis. OBJECTIVE: To review studies that address the association between F. nucleatum and CRC. METHODS: The MEDLINE PubMed database was searched using the terms «colorectal cancer¼ and «Fusobacterium nucleatum¼, retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis. RESULTS: The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumor tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95% CI: 2.359-4.462). CONCLUSION: There is a more frequent presence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.

Colitis ulcerosa y anemia aplásica / Ulcerative colitis and aplastic anemia

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