Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 15 de 15
Filtrar
Mais filtros











Intervalo de ano de publicação
1.
Endocr Pathol ; 24(3): 132-5, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23702575

RESUMO

Malignant teratoma of the thyroid is a rare and aggressive tumor, frequent in children than in adults. Histologically, thyroid teratomas usually show a predominance of a neuroectodermal component. Mature cartilage and bone may be present. We present the case of primary malignant teratoma of the thyroid in a 64-year-old man. Histologically, the tumor displayed a predominant neuroectodermal component. The diagnosis was confirmed by immunohistochemistry. The patient underwent a radical thyroidectomy with central neck dissection as primary treatment and radioiodine treatment afterwards. The patient had local and distant recurrence. A second surgery was performed with poor results and the patient died 3 months afterwards.


Assuntos
Teratoma/patologia , Neoplasias da Glândula Tireoide/patologia , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Teratoma/diagnóstico , Teratoma/cirurgia , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia
2.
Gut ; 52(7): 1054-9, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12801966

RESUMO

BACKGROUND: Cytokines produced in mesenteric lymph nodes of cirrhotic rats with bacterial translocation may participate in circulatory alterations of cirrhosis. AIM: To investigate whether cirrhotic patients present an increased local generation of cytokines in mesenteric lymph nodes. METHODS: Mesenteric lymph nodes from 26 cirrhotic and 10 control patients were assessed for tumour necrosis factor alpha (TNF) and interleukin 6 mRNA and protein expression by competitive reverse transcription-polymerase chain reaction, and by enzyme immunoassay and immunohistochemistry, respectively. RESULTS: Interleukin 6 levels were not different between cirrhotics and controls. Protein and mRNA TNF levels in mesenteric lymph nodes from cirrhotics were higher than in controls (p<0.05). Tissue expression of TNF by immunohistochemistry was more abundant in cirrhotics. Ascitic patients showed higher TNF levels (47 (34-54) pg/mg protein) than patients without ascites (18 (17-25) pg/mg protein) (p<0.001). Elevated TNF levels (>28 pg/mg protein) in cirrhotics were associated with a higher Child-Pugh score, the antecedent of ascites, a lower prothrombin rate, and higher bilirubin and blood TNF levels. The strongest association, confirmed by multivariate analysis, was with the presence of ascites (p<0.001). Bacterial infections after transplantation, mainly by enteric bacteria, were only detected in patients with high TNF levels in mesenteric lymph nodes (33% of patients; p=0.05). CONCLUSION: Patients with advanced liver cirrhosis, and especially with ascites, have increased local production of TNF in mesenteric lymph nodes that, in common with experimental cirrhosis, may also be induced by bacterial translocation.


Assuntos
Ascite/metabolismo , Cirrose Hepática/metabolismo , Linfonodos/metabolismo , Mesentério/metabolismo , Fator de Necrose Tumoral alfa/biossíntese , Ascite/complicações , Infecções Bacterianas/complicações , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Humanos , Imuno-Histoquímica/métodos , Interleucina-6/análise , Cirrose Hepática/complicações , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
3.
An Pediatr (Barc) ; 58(1): 59-62, 2003 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-12628121

RESUMO

Hepatomegaly and alterations in hepatic function are common to all patients with sickle-cell disease. In these patients, hepatic sickling is a manifestation of severe intrahepatic vaso-oclusive crises, even at levels of 25 % HbS and hematocrits of more than 45-50 %, which in 10 % of cases can lead to acute hepatic failure (AHF). AHF can be due to a variety of causes, including hematologic malignancies, but T cell lymphoma, which is usually secondary to diffuse hepatic infiltration and ischemia, is an exceptional cause, although other mechanisms can be involved. Cytokines released by lymphomas have recently been implicated as a cause of AHF.We describe a black girl with sickle cell disease, who developed AHF due to T cell lymphoma without lymphomatous infiltration of the liver. The only mechanism found to explain the clinical findings was release of cytokines by lymphoma. In patients with AHF of unknown etiology we propose early liver biopsy, because prognosis depends on the presence or absence of hepatic tumour infiltration. If AHF develops in a patient with diagnosed malignant disease, cytokine release may be the cause of AHF. Consequently, early diagnosis of the underlying disease and provision of liver support, as well as direct removal of inflammatory mediators from the circulation by exchange transfusion or other methods, should be the main priorities.


Assuntos
Anemia Falciforme/complicações , Falência Hepática Aguda/etiologia , Linfoma de Células T/complicações , Criança , Feminino , Humanos
4.
An. pediatr. (2003, Ed. impr.) ; 58(1): 59-62, ene. 2003.
Artigo em Es | IBECS | ID: ibc-17309

RESUMO

En pacientes con anemia de células falciformes, la hepatomegalia y alteración de la función hepática son comunes. En ellos, las crisis vasooclusivas intrahepáticas graves, pueden ocurrir con niveles de hemoglobina del 25 per cent y hematocrito superior a 45-50 per cent. Un 10 per cent pueden llegar a fallo hepático agudo (FHA). El FHA tiene diversas causas, entre ellas los procesos hematológicos malignos, excepcionalmente el linfoma de células T, que por lo general produce infiltración hepática e isquemia, aunque éste no es el único mecanismo lesional. Recientemente se ha considerado a las citocinas liberadas por linfomas como causa de FHA. Se presenta el caso de una niña de raza negra, con enfermedad de células falciformes, que presentó FHA secundario a un linfoma de células T que no infiltró al hígado, y donde el único mecanismo que se encontró para explicar el cuadro clínico fue el mediado por las citocinas. Cuando los estudios de imagen no confirman la infiltración hepática por células malignas, debe valorarse realizar una biopsia hepática, pues el pronóstico del FHA variará en función de si hay o no infiltración tumoral. Si la causa del FHA es compatible con una enfermedad neoplásica, las citocinas pueden ser las responsables del FHA. Por ello, establecer medidas de soporte de la función hepática e iniciar tratamiento precoz de la enfermedad de base, además de remover directamente estos mediadores inflamatorios de la circulación mediante exanguinotransfusión u otro procedimiento debe constituir la principal preocupación (AU)


Assuntos
Criança , Feminino , Humanos , Linfoma de Células T , Anemia Falciforme , Falência Hepática Aguda
5.
Haematologica ; 86(9): 934-40, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11532621

RESUMO

BACKGROUND AND OBJECTIVES: Bone marrow biopsies are routinely performed in the staging of patients with lymphoma. Despite the lack of evidence for its usefulness, many institutions include flow cytometry (FC) of bone-marrow aspirates in an attempt to increase sensitivity and specificity. The aim of this study is to evaluate the usefulness of FC for the assessment of bone-marrow involvement by lymphoma in follicular (FL) and diffuse large B-cell lymphomas (DLBCL). DESIGN AND METHODS: Seventy-nine bone marrow biopsies from 65 patients diagnosed with FL or DLBCL were examined to compare histology and FC for the assessment of bone-marrow involvement by lymphoma. RESULTS: Bone marrow histology showed involvement (BM+) in 16 cases (20.3%), lack of infiltration (BM(-)) in 52 cases (65.8%) and undetermined or undiagnosed for involvement (BMu) in 11 cases (13.9%). FC was positive for involvement in 28 cases (35.4%) and negative in 51 cases (64.6%). 65 cases (95%) showed concordance between the results of morphology and FC (BM(+)/FC(+) or BM(-)/FC(-)). No BM(+)/FC(-) cases were observed. 3 cases showed discrepant results (BM(-)/FC(+)). In these 3 cases the molecular studies (PCR) demonstrated clonal rearrangement of the heavy immunoglobulin chain (IgH) and/or bcl2-IgH in agreement with the flow results. Among the 11 cases with BMu, all but 2 were FC(+) and concordance with the PCR results was seen in 9 cases (81.9%). INTERPRETATION AND CONCLUSIONS: We conclude that FC is just as sensitive or perhaps slightly more sensitive than histology in the detection of bone marrow involvement in FL and DLBCL. FC studies may be warranted in those cases in which the morphology is not diagnosed. The clinical relevance of the small clonal B-cell population in patients without histologic bone marrow involvement (BM(-)/FC(+) cases) remains an open question.


Assuntos
Medula Óssea/patologia , Citometria de Fluxo/normas , Linfoma não Hodgkin/patologia , Humanos , Imunofenotipagem , Linfoma de Células B/diagnóstico , Linfoma de Células B/patologia , Linfoma Folicular/diagnóstico , Linfoma Folicular/patologia , Linfoma Difuso de Grandes Células B/diagnóstico , Linfoma Difuso de Grandes Células B/patologia , Linfoma não Hodgkin/diagnóstico , Sensibilidade e Especificidade
6.
Abdom Imaging ; 20(5): 466-9, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-7580787

RESUMO

We present a case of aortocaval fistula (ACF) secondary to spontaneous rupture of an atherosclerotic infrarenal aortic aneurysm into the inferior vena cava that was initially diagnosed with computed tomography (CT). This is believed to be the first report of this condition with CT demonstration of the exact site of fistula and CT-pathologic correlation. We retrospectively reviewed the CT findings of another two cases of ACF and the previous literature.


Assuntos
Doenças da Aorta/diagnóstico por imagem , Fístula Arteriovenosa/diagnóstico por imagem , Veia Cava Inferior , Aorta Abdominal/diagnóstico por imagem , Aorta Abdominal/patologia , Aneurisma da Aorta Abdominal/complicações , Doenças da Aorta/patologia , Ruptura Aórtica/complicações , Fístula Arteriovenosa/etiologia , Fístula Arteriovenosa/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Veia Cava Inferior/diagnóstico por imagem , Veia Cava Inferior/patologia
7.
Cir Pediatr ; 7(4): 196-9, 1994 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-7865366

RESUMO

Post-Transplant Lymphoproliferative Disorders are due to continuous B-lymphocyte proliferation induced by Epstein-Barr Virus (EBV) infection which is recovered in 88% of transplanted patients. These disorders may present clinically as lymphadenopathic syndrome with lymphoid tissue hyperplasia, systemic as a mononucleosis-like syndrome and lymphomatous syndrome, indistinguishable from non-Hodgkin's lymphoma. We present 10 patients of PTLD classified as 7 lymphadenopathic, 1 systemic (this patient had both syndromes) and 3 lymphomatous tumours. At present, PTLD treatment consists of surgical removal of accessible masses or post-chemotherapy (ChT) tumour rests, total or partial withdrawal of immunosuppressive drugs and ChT following the Sociéte Française d'Oncologie Pédiatrique (SFOP) protocol for non-Hodgkin's lymphoma.


Assuntos
Transplante de Fígado , Transtornos Linfoproliferativos/etiologia , Adolescente , Criança , Feminino , Humanos , Terapia de Imunossupressão , Transplante de Fígado/efeitos adversos , Transtornos Linfoproliferativos/terapia , Masculino , Complicações Pós-Operatórias , Fatores de Tempo
8.
Histopathology ; 24(1): 13-22, 1994 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8144140

RESUMO

Waldeyer ring lymphomas belong to a category of tumours which has not yet been fully defined. Their relation to mucosa-associated lymphoid tissue (MALT) and other extranodal lymphomas remains largely unknown. We performed a clinicopathological retrospective study of 79 patients, and compared them with a series of MALT and nodal lymphomas. Tumours from the nasopharynx and palatine tonsil showed similar histological profiles, with a predominance of large B-cells. Centroblastic lymphomas constituted the largest group (n = 45), followed by those of centrocytic type (9) with smaller groups of centroblastic-centrocytic (5) and Hodgkin's lymphomas (2). Three monocytoid B-cell lymphomas were identified. Only one case could be classified as MALT lymphoma. The frequency of bcl-2 expression in large B-cell tumours of Waldeyer's ring has an intermediate range between large B-cell lymphomas occurring in mucosal and nodal locations. Epitheliotropism was present in all low-grade cases, and was therefore not a useful marker in the identification of potential MALT lymphomas in contrast with other mucosal sites. Comparative survival studies showed significant overall differences between Waldeyer ring lymphomas, MALT and nodal cases. These disappeared after taking stage and histological grade into account. We conclude that Waldeyer ring lymphomas show distinctive features, mainly in terms of histological distribution and immunophenotype. The key factor determining their behaviour could be their different spreading capability. These findings suggest that extranodal lymphomas are heterogeneous, and indicate the need for additional efforts to clarify this.


Assuntos
Linfoma/patologia , Neoplasias Nasofaríngeas/patologia , Neoplasias Tonsilares/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Humanos , Linfonodos/patologia , Tecido Linfoide/patologia , Masculino , Pessoa de Meia-Idade , Mucosa/patologia , Proteínas Proto-Oncogênicas/análise , Proteínas Proto-Oncogênicas c-bcl-2 , Análise de Sobrevida
9.
Med Clin (Barc) ; 101(7): 261-3, 1993 Sep 11.
Artigo em Espanhol | MEDLINE | ID: mdl-7746002

RESUMO

Primary non Hodgkin's lymphoma of the breast (PNHLB) its an unusual presenting form of malignant breast diseases. Its estimated frequency is around 0.05-0.5% of all breast tumors. Three cases of PNHLB are presented. We analyse the characteristics of presenting features and also we discuss the therapeutic and prognostic implications. They can be initially confused with a typical breast carcinoma due to the unspecific clinical findings with the difficulty to obtain a definitive diagnosis based only on cytologic grounds. The therapeutic and prognostic consequences underlines the importance of immunohistochemistry in the diagnosis of PNHLB.


Assuntos
Neoplasias da Mama/patologia , Linfoma não Hodgkin/patologia , Adulto , Idoso , Carcinoma/patologia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade
11.
Eur Urol ; 14(1): 80-2, 1988.
Artigo em Inglês | MEDLINE | ID: mdl-2830115

RESUMO

In 1967, Bolande coined the term, congenital mesoblastic nephroma, in relation to a rare benign kidney tumor which is mainly found in infancy and that can be misdiagnosed clinically as a Wilm's tumor. It has been called renal fetal hamartoma, leiomyomatous hamartoma and renal leiomyoma. Four cases have been described in adults previously and here we report a new case.


Assuntos
Neoplasias Renais , Tumor de Wilms , Hamartoma , Humanos , Masculino , Pessoa de Meia-Idade , Terminologia como Assunto
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA