[Natural foci of leptospirosis on the territory of Moscow in 1995 - 2004].

The results of ten-year observations of the natural foci of leptospirosis on the territory of Moscow are presented. Information on the foci, the main species of small mammals (the reservours of the infection), the etiological structure of leptospires, circulating among rodents and insectivores, is given.

[Natural foci of leptospirosis in Moscow in 1995 - 2004].

The article deals with the results of the 10-year study of the synanthropic urban foci of leptospirosis on the territory of Moscow. Information on the manifestation of the activity of the foci under study, rodents serving as the reservoir of infection in these foci, the etiological structure of the leptospires among these rodents, the state of leptospirosis morbidity among humans is presented.

[Regulatory role of DOPA and components of the cyclic adenosine-3',5'-monophosphate system]. / O reguliatornoi roli DOFA i komponentov sistemy tsiklicheskogo adenozin-3'-5'-monofosfata.

It was shown on albino mice that when DOPA-3H (20 muCi/mouse) was administered before nonradioactive DOPA (1 mg/mouse) tritium accumulation in the tissue of Harding-Passi's melanoma of these mice proved to increase. Melanoma radioactivity in this experimental group was double that in the tumour tissue of the animals to which DOPA-3H alone was administered. Examination of the adenylate cyclase, phosphodiesterase activity and of the level of cAMP in melanoma of mice 2 hours after DOPA administration (1 mg/mouse) showed accumulation of cAMP and an increase in the phosphodiesterase activity; as to adenylate cyclase activity--it fell. It is suggested that DOPA realizes its effect not only as melanin precursor, but also through the cAMP system, influencing the melanogenesis enzymes activity.