The chemistry of benzydamine.

After a brief introduction on the chemistry of indazoles in general, the most important clinically used drugs of this series, i.e. benzydamine, bendazac and its salts and esters, are mentioned. The possible synthetic processes for benzydamine are then reviewed and any possible occurring by-products and impurities, including their quantitative limits, are discussed.

[Relation between chemical constitution and sweet taste. XV. Sulfamic acids and sulfur chlorides]. / Rapporti fra costituzione chimica e sapore dolce. Nota XV. Acidi sulfamici e solfocloruri.

In studies concerning the relation between structure and sweetness in sulfamic acid derivatives, two new sweeteners (VI) and (VIII) were found. Their corresponding sulfochlorides are also unexpectedly sweet-tasting.

[Antiviral agents. XIX. Amantadine derivatives and several others]. / Chemioterapici antivirali. Nota XIX-Derivati adamantanici e vari

The synthesis and pharmacological activity of several adamantane derivatives and analogs of tilorone are described as part of a systematic research on potential antiviral compounds and/or interferon inducers.

[Relationship between chemical structure and sweet taste. XIII. Derivatives of L-acylamidosuccinanilic acids]. / Rapporti fra costituzione chimica e sapore dolce. Nota XIII. Derivati L-acilamidosuccinanillci

Several derivatives of L-acylamidosuccinanilic acids have been prepared inorder to study the relationship between the chemical structure and the sweetening activity by modifying the amino or the acylamido portions of the molecule. Some synthesized compounds possess a pronounced sweet taste, the L-4'-nitro-(2,2,2-trichloroacetamido)succinanilic acid is the most outstanding compound, being approximately 3000-4500 times as sweet as sucrose.

[Antiviral chemotherapeutic agents. XVIII. Adamantane derivatives of amphetamine. Their potential interest as autonomic and antiparkinson agents]. / Chemioterapici antivirali. Nota XVIII - Amfetamina adamantilica e derivati. Loro potenziale interesse anche come farmaci autonomici ed antiparkinsoniani

Adamantane isologs of amphetamine, methamphetamine and pheniprazine and several derivatives were synthesized in order to study the influence of their more pronounced lipophilic characteristics on their biological properties. A preliminary examination of their toxicity, antiviral, CNS stimulant and antiparkinson activity is described. The adamantyl amphetamine, which proved active, will be further studied.