Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.

BACKGROUND AND AIM: A fraction of children with obesity have increased serum cortisol levels. In this study, we describe the clinical characteristics of obese children and adolescents with elevated morning serum cortisol levels and the relationship between the cortisol levels and components of the metabolic syndrome. METHODS: Retrospective medical record review study of children aged 4 to 18 years with overweight or obesity seen for obesity management in the Pediatric Obesity Clinic of the UZ Brussel between 2013 and 2015. RESULTS: A total of 234 children (99 boys and 135 girls) with overweight (BMI z-score > 1.3) without underlying endocrine or genetic conditions were included. Mean (SD) age was 10.1 (2.8) years, BMI SD-score 2.5 (0.6), and body fat percentage 37% (7.9). Serum fasting cortisol levels were elevated (>180 µg/L) in 49 children, normal (62-180 µg/L) in 168, and decreased (<62 µg/L) in 12. Serum fasting cortisol was not significantly correlated with gender, age, or degree of adiposity. But correlated significantly with fasting glucose (Rs = 0.193; p < 0.005), triglycerides (Rs = 0. 143; p < 0.05), fibrinogen (Rs = 0.144; p < 0.05) and leptin levels (Rs = 0.145; p < 0.05). After adjustment for serum insulin and leptin, the correlation between serum cortisol and fasting glucose remained significant. CONCLUSION: Elevated morning serum cortisol levels were found in 20% of overweight or obese children and adolescents, irrespective of the degree of adiposity, and were associated with higher fasting glucose, irrespective of underlying insulin resistance. The long-term cardiometabolic consequences of hypercortisolemia in childhood obesity needs further study.

Aeromonas wound infection in a healthy boy, and wound healing with polarized light.

Introduction. At emergency departments, history taking is often very brief. We present a case of an Aeromonas wound infection, that illustrates the importance of careful history taking. We also report the first successful use of polarized light as additional therapy for healing of this infectious wound. Case presentation. A healthy boy was diagnosed with a wound infection, after a fall onto rocks. At first, it remained unmentioned that there had been contact with ditchwater, so he was treated with amoxicillin-clavulanic acid. Only after the finding of an Aeromonas strain in the wound culture, and treatment with a fluoroquinolone, did he recover. Wound healing was aided with the use of polarized light, and with good effect. To our knowledge, this is the first report on the effect of polarized light on the healing of infectious wounds. Conclusion. Careful history taking is essential for adequate empiric therapy when faced with wounds and wound infections. Aeromonas infections are associated with water exposure, and should be treated with fluoroquinolones. Polarized light seems to have a good result on healing of infectious wounds.