RESUMO
The review considers features of efferent therapy employing extracorporeal systems, the devices known as "artificial liver" and "bioartificial liver" in the treatment of liver insufficiency. Analysis of literature data shows the need for further development of these biomedical studies and the search for optimal solutions in the selection of the source of hepatocytes, the development of bioreactors and biomaterials forming the basis of devices like "bioartificial liver". Taking into consideration certain advantages and disadvantages typical for various methods of extracorporeal support of the functional state of the liver one can evaluate prior experience in the treatment of liver diseases and approaches to the development of new, more effective medical technologies.
Assuntos
Técnicas de Cultura de Células/métodos , Hepatócitos/fisiologia , Hepatopatias/terapia , Fígado Artificial , Materiais Biocompatíveis/química , Materiais Biocompatíveis/metabolismo , Reatores Biológicos , Técnicas de Cocultura , Desenho de Equipamento , Fibroblastos/citologia , Fibroblastos/metabolismo , Hepatócitos/citologia , Humanos , Hepatopatias/metabolismo , Hepatopatias/fisiopatologia , Fotoferese/instrumentação , Fotoferese/métodos , Diálise Renal/instrumentação , Diálise Renal/métodosRESUMO
Daily (for 3 days) 1-hour immobilizations were followed by an increase in protein oxidative modification and leukocyte infiltration in the liver, and a decrease in monoamine oxidase B activity. Receptor antagonist of glucocorticoids RU38486 limited the stress-induced increase in protein carbonylation and decrease in monoamine oxidase B activity in the organ and enhanced leukocyte infiltration of the liver.
Assuntos
Antagonistas de Hormônios/farmacologia , Fígado/metabolismo , Mifepristona/farmacologia , Carbonilação Proteica/efeitos dos fármacos , Estresse Psicológico/metabolismo , Animais , Animais não Endogâmicos , Feminino , Glucocorticoides/antagonistas & inibidores , Fígado/efeitos dos fármacos , Fígado/imunologia , Masculino , Monoaminoxidase/metabolismo , Ratos , Restrição Física , Estresse Psicológico/imunologiaRESUMO
An inverse relationship between erythropoiesis intensity and microsomal oxidation level has been detected during the early postnatal period in rats with high resistance to hypoxia.
Assuntos
Heme/biossíntese , Microssomos/metabolismo , Porfirinas/metabolismo , Anilina Hidroxilase/metabolismo , Animais , Animais Recém-Nascidos , Sistema Enzimático do Citocromo P-450/metabolismo , Hexobarbital/farmacologia , Oxirredução , Ratos , Sono/efeitos dos fármacos , Sono/fisiologiaRESUMO
The therapeutic efficiency of bioactive preparations of the liver and spleen in the treatment of experimental toxic cirrhosis of the liver is shown. Evaluation of the nucleolar organizer activity showed the highest efficiency of treatment with human fetal liver extract.