[Combined manifestations of natural foci in the territory of the Vologda province]. / Sochetannoe proiavlenie prirodnykh ochagov na territorii Vologodskoi oblasti.

Based on epizootological and epidemiological investigations in the Vologda province since 1958 till 2000, the combined territorial and temporal manifestations of natural foci of diseases was revealed. A natural focus occupies a complex of biotopes, and in different time the focus is activated in different areas, such as a river plain, marsh, meadow-field, and forest. Most commonly an activation of the natural focus appears in a border zone of three biotopes, namely, a forest, meadow-field, and river plain. A dependence of activation of various natural foci upon local climate conditions and fluctuations of micromammalian host number are considered.

[Further study of hantavirus circulation in the Russian Federation]. / Dal'neishee izuchenie tsirkuliatsii khantavirusov v Rossiiskoi Federatsii.

Lung specimens of 1514 small mammals of 35 species captured in 1991-1995 at 9 territories of Russia were tested in ELISA for virus antigens of hemorrhagic fever with the renal syndrome (HFRS). The antigens were detected in lung specimens of Clethrionomys glareolus, Microtus arvalis, Microtus gregalis, Microtus fortis, Arvicola terrestris, Apodemus agrarius, Micromys minutus, and Sorex sp., well known as Hantavirus reservoirs, captured in the Vologda, Yaroslavl, Saratov, Astrakhan, and Chita regions. Infection of Microtus maximoviczii revealed in the Chita region was first found in China. Previously there were no reports about the circulation of hantaviruses in this region. Our study added one more host to the list of HFRS virus hosts: Meliones tamariscinus.

[Relapse of Q fever in childbirth and transmission of the pathogen to the child]. / Retsidiv likhoradki ku u rozhenitsy i peredacha vozbuditelia rebenku.

A case was described when a newborn was inoculated with Coxiella Burnetti as a result of infection relapse (in 8 months after acute disease) in his mother. Coxiella Burnetii were isolated from blood of both patients. Dynamics of humoral immunity indices in mother was observed both at the primary disease and during the period of infection relapse.

[An epidemiologic projection of foci of Q fever within herds]. / Epidemiologicheskaia proektsiia vnutristadnykh ochagov likhoradki Ku.

In one of the rural regions of the nonchernozem zone retrospective epidemiological diagnosis was carried out in connection with high morbidity rates in acute respiratory diseases and influenza. This diagnosis was shown to cover cases of Q fever. Altogether 172 cases of this infection were retrospectively diagnosed. This infection affected persons working at one of sheep-breeding complexes, as well as at enterprises, technologically linked with this complex. Sheep proved to be the source of this infection, that was confirmed both serologically and by the registered cases of the isolation of Coxiella strain from sheep.

[Use of modified Ayling's method for detection of homozygotes and heterozygotes for phenylketonuria gene]. / Primenenie modifitsirovannogo metoda Eiling dlia vyiavleniia gomo- i geterozigot po genu fenilketonurii.

Activity of phenylalanine hydroxylase from human leukocytes was shown to depend on concentration of phenylalanine and pteridine cofactor; optimal concentrations of the substances were estimated. Using this optimized procedure activity of phenylalanine hydroxylase was studied in leukocytes of homo- and heterozygotes by the phenylketonuria gene as well as in the cells of donors. The mean values of the enzymatic activity were distinctly different in the groups of homo-, heterozygote-bearing patients and in healthy persons, although a slight overlapping of the patterns was observed between the groups. Presence of "atypical" forms of phenylketonuria appears to be responsible for this overlapping. The modified procedure for estimation of phenylalanine hydroxylase activity in leukocytes might be used for differential diagnostics of phenylketonuria.

[Incidence among children of Candida yeast-like fungi]. / Rasprostranennost' sredi detei drozhzhepodobnykh gribov Candida.

The incidence of Candida fungi in healthy children and those suffering from noninfectious diseases was studied. In dealthy children--from the time of birth to 7 years--it constituted 39%, and in sick children treated with antibiotics--53%. Dependence of the frequency of Candida fungi state on age was revealed; there was also a correlation between the amount of the fungi and the presence of lesions on the oral mucosa. Candida fungi were also revealed in the washings from the environmental objects, on the pharyngeal mucosa and hands of the personnel, and in the samples of food for children.