A Retrospective Study Comparing Laparoscopic Transabdominal Cerclage: Pre-Pregnancy Versus in Pregnancy With Their Reproductive Outcomes and Safety.

OBJECTIVES: To compare the efficacy of laparoscopic transabdominal cerclage (TAC) pre-pregnancy and laparoscopic TAC in pregnancy in treating cervical insufficiency. METHOD: A retrospective analytical study comparing outcomes of laparoscopic TAC pre-pregnancy with laparoscopic TAC in pregnancy. A total of 178 patients who underwent laparoscopic TAC at our hospital were enrolled in the study. In total, 122 patients underwent interval cerclage, and 56 patients underwent cerclage during pregnancy. RESULTS: A total of 178 patients who met the inclusion criteria were included in the analysis. Second-trimester abortions decreased by 50%, with an overall increase in full-term live births (32.53%) in patients undergoing laparoscopic TAC pre-pregnancy. The fetal survival rate was around 90% and 85% with laparoscopic TAC pre-pregnancy and laparoscopic TAC in pregnancy, respectively. Although the obstetric outcomes of laparoscopic TAC pre-pregnancy and in pregnancy were comparable, laparoscopic TAC pre-pregnancy was safer than laparoscopic TAC in pregnancy due to the complications associated with the procedure during pregnancy. CONCLUSIONS: Laparoscopic TAC pre-pregnancy yielded better reproductive outcomes than laparoscopic TAC in pregnancy and was associated with fewer perioperative complications.

Sulfamethoxazole removal in membrane-photocatalytic reactor system - experimentation and modelling.

In this study, the efficacy of membrane-photocatalytic reactor (MPR) in sulfamethoxazole (SMX) removal was explored at a fixed initial SMX concentration, i.e. 100 mg/L. A supported catalyst, i.e. TiO2 on granular activated carbon (GAC-TiO2), was used for MPR experiments. The SMX removal efficiency of the MPR was investigated under a range of hydraulic retention time (i.e. HRT from 51 to 152.5 min) and TiO2 catalyst dosage (55-50 mg/L). A maximum SMX removal efficiency of 83.6% was observed under 220 mg/L catalyst dosage and 80 min HRT. The increase in catalyst dosage from 55 to 550 mg/L has increased the transmembrane pressure of the reactor from 9.8 to 22.2 kPa. A multiple non-linear regression model was developed based on the experimental data and its significance was analyzed using two-way ANOVA. Based on the model, the optimal HRT and catalyst dosage for complete SMX removal (100%) were found out. The comparison of photocatalytic degradation experiments with sorption experiments conducted earlier revealed that SMX removal in the MPR was mainly by photocatalytic degradation and not by adsorption onto GAC-TiO2 catalyst. However, the performance of MPR in removing other emerging pollutants from real-time wastewaters could be explored before its field-scale application.

Photocatalytic-oxidation and photo-persulfate-oxidation of sulfadiazine in a laboratory-scale reactor: Analysis of catalyst support, oxidant dosage, removal-rate and degradation pathway.

The extent of sulfadiazine (SDZ) removal via photo-degradation (UV-C), photocatalysis with TiO2 (UV-C/TiO2) and photo-persulfate-oxidation (UV-C/PS) was investigated in a batch reactor under different UV-C power levels (i.e. 14, 28, 42 and 56 W). Moreover, effects of suspended/immobilized catalyst, i.e. TiO2 slurry/TiO2 supported on granular activated carbon (GAC-TiO2), on SDZ removal and corresponding SDZ degradation kinetics under different catalyst loading (1-6 g/L) were explored. Around 41.7% SDZ removal was observed after 120 min in UV-C system at the highest power level, i.e. 56 W. On the other hand, photocatalysis with TiO2 and GAC-TiO2 has shown better SDZ removal than photo-degradation. In UV-C/TiO2 (4 g/L and 28 W) and UV-C/GAC-TiO2 (5 g/L and 28 W) systems, SDZ removals were 91.8% after 120 min and 100% after 60 min, respectively; however, TOC analysis has revealed that 45.4% and 60.8% SDZ was mineralized in these systems, respectively. In UV-C/PS system, near complete degradation of SDZ (99.8%) was observed within 10 min under 50 mg/L of PS and 28 W UV illumination. On the other hand, complete SDZ removal was observed in PS alone system at a dosage of 1000 mg/L but the formation of SO42- was found to be a drawback. In photolysis and photocatalysis systems, SDZ removal followed pseudo-first-order kinetics whereas the kinetics followed pseudo-second-order in UV-C/PS system. The comparison of electrical energy consumed (EEO) in different systems revealed that UV-C/GAC-TiO2 and UV-C/PS system were energy efficient compared with other systems. The LC-MS analysis has confirmed the cleavage of C-N bonds in the pyrimidine ring followed by S-N bonds in the sulfonyl group, which was found to be the major degradation pathway of SDZ.

Biochemical characterization of a key step involved in 2H4MB production in Decalepis hamiltonii.

Decalepis hamiltonii is widely known for its flavour molecule 2-Hydroxy-4-Methoxy Benzaldehyde (2H4MB), a structural isomer of vanillin. As the biosynthetic pathway of 2H4MB is not known, we hypothesised 2H4MB origins could be from phenylpropanoid pathway (PPP). Accordingly, a study was conducted using PPP inhibitors (viz. piperonylic acid, MDCA and propanil) against in vitro root cultures of D. hamiltonii to find the branch of PPP which catalyses the 2H4MB formation. HPLC analysis was carried out to quantify 2H4MB levels in control and respective inhibitor treated root cultures in vitro. The results obtained revealed that piperonylic acid did not inhibit 2H4MB biosynthesis in the given period, whereas MDCA and propanil had the marked inhibitory effect. The inhibitory effect was evident with 13.2, 33.6 and 37.9% decrease in 2H4MB levels at 50, 100 and 150mM concentration of MDCA respectively in comparison with control roots. Similarly, the inhibitory effect of propanil on 2H4MB biosynthesis was obvious with 23.7, 49.5 and 57.9% decrease in 2H4MB levels at 50, 100 and 150µM concentration of inhibitor respectively when compared with control roots. Propanil showed a greater slow down effect on 2H4MB biosynthesis compared to MDCA. Incorporation of 0.1, 0.5 and 1.0mM ferulic acid as a precursor to in vitro root cultures of D. hamiltonii showed an increase in 2H4MB levels at the rate of 3.1, 107 and 94.1% respectively as quantified by HPLC analysis. However, ferulic acid in conjunction with propanil did not show any increase in 2H4MB levels. This clearly explains that ferulic acid is channelled through the 4-CL (4-coumarate CoA ligase) enzyme, where it would be converted to feruloyl-CoA and could be further converted to 2H4MB in D. hamiltonii.

A unique method of retention for gum stripper- a case report.

Successful restoration of partially edentulous situations, especially kennedy's class-I, II &IV requires lot of contemporary and conventional treatment approaches. Semi precision attachments play a major role in retention of clinically challenging partially edentulous situation. Attachment retained partial dentures can be one of the successful treatment option in prosthdontics. This article presents a unique technique of retaining gum stripper using semi precision attachments.