Berries, una nueva alternativa terapéutica en dermaología / Berries, a new therapeutic alternative in dermatology

Los berries son frutos ampliamente estudiados y por décadas se han usados en distintas especialidades como herramienta terapéutica. Se han realizado múltiples estudios que demuestran los efectos beneficiosos de su consumo y el uso de sus componentes en diferentes presentaciones. En la literatura mundial no existen publicaciones de casos clínicos del área dermatológica tratados con formulaciones en base a berries. La siguiente revisión presenta evidencias que apoyan los potenciales efectos beneficiosos de los componentes de los berries y sus acciones terapéuticas en el área de la salud.

Berry fruits have been widely studied. They have been used as a ther-apeutic tool in a lot of areas in medicine. There have been many stud-ies that show the benefi cial eff ects of its consumption and the use ofits components in different presentations. In the international literature there are no reports of clinical cases of the dermatologic area treated with formulations on the basis of berries. The following review will present evidences supporting that berries components and its actions can exert potencially healthy effects.

Carcinoma de células de Merkel: a propósito de dos casos / Merkel cell carcinoma: report of two cases

El carcinoma de células de Merkel es un raro carcinoma neuroendocrino primario de la piel que generalmente se presenta como un nódulo redondeado, violáceo, solitario o como una placa indurada en áreas fotoexpuestas de pacientes añosos. El diagnóstico histopatológico puede ser difícil debido a su semejanza con el carcinoma metastásico de células pequeñas de pulmón, linfomas y otros tumores cutáneos. Para la distinción de tumores primarios pobremente diferenciados o metástasis se requiere de análisis inmunohistoquímico. La citoqueratina 20 constituye un marcador sensible y específico para este tumor y es útil para distinguirlo de otras neoplasias, malignas o benignas. Presentamos dos casos vistos en nuestro Servicio con este diagnóstico y una breve revisión de la literatura.

Merkel cell carcinoma is a rare primary neuroendocrine carcinoma of the skin that usually appears as a solitary, violaceous, dome-shaped nodule or indurated plaque in a sun exposed area of elderly patients. Histopathologic diagnosis may be difficult because of histologic and immunohistochemical similarities with metastatic small cell lung carcinomas, lymphomas, and other cutaneous neoplasms. Distinction from poorly differentiated oat cell primary tumors or metastasis requires immunohistochemical analysis. Cytokeratin 20 is a sensitive and specific marker for Merkel cell carcinoma and is helpful in distinguishing this tumor among other malignant and benign neoplasms. We report two cases with this diagnosis seen at our department and a brief report of the literature.

[Animal mites transmissible to humans and associated zoonosis]. / Acarosis y zoonosis relacionadas.

Mites that affect animals (acariasis) can occasionally be transmitted to humans by incidental contact producing pruritus and dermatitis. Animals such as dogs, cats, mice, birds and reptiles, harbour several mite species. Hemophage mites and those that feed on lymph have the potential of transmitting important zoonotic agents (cuales??). The presence of lesions of unclear origin and a history of contact with pets or wild animals should alert towards the possibility of acariasis. Diagnosis is based on direct visualization of the mite,analysis of its morphology and obtaining information on the animal host. Awareness of these acarosis and the responsible care of pets and animals are the most relevant preventive measures.

Acarosis y zoonosis relacionadas / Animal mites transmissible to humans and associated zoonosis

Mites that affect animals (acariasis) can occasionally be transmitted to humans by incidental contact producing pruritus and dermatitis. Animals such as dogs, cats, mice, birds and reptiles, harbour several mite species. Hemophage mites and those that feed on lymph have the potential of transmitting important zoonotic agents (cuales??). The presence of lesions of unclear origin and a history of contact with pets or wild animals should alert towards the possibility of acariasis. Diagnosis is based on direct visualization of the mite,analysis of its morphology and obtaining information on the animal host. Awareness of these acarosis and the responsible care of pets and animals are the most relevant preventive measures.

Los ácaros de animales (acariasis) pueden transmitirse en forma accidental al hombre al estar en contacto con ellos, produciendo lesiones características (pápulas o vesículas) y ocasionando una dermatitis pruriginosa (acarosis). Existen diversas especies de ácaros, que se encuentran en perros, gatos, roedores, aves y reptiles. Los ácaros hematófagos o los que se alimentan de linfa tienen el potencial de transmitir importantes agentes zoonóticos. La presencia de lesiones sin una etiología clara y el antecedente de contacto con animales, tanto mascotas como animales silvestres, ayudan a plantear esta etiología. El diagnóstico se realiza con la visualización del acaro, morfología y tipo de hospedero animal. El conocimiento de estas acarosis y el control responsable de mascotas y animales, son las principales medidas de prevención.

Angiomixoma superficial preauricular: importancia médica / Preauricular superficial angiomyxoma: medical importance

Los angiomixomas superficiales son tumores benignos poco frecuentes y de presentación clínica variable. Se ubican de preferencia en tronco, extremidades y región de cabeza y cuello. El diagnóstico es histológico y relativamente fácil debido a las características propias de la lesión. El angiomixoma puede ser marcador de mixomas cardiacos y estar asociado simultáneamente con el síndrome o complejo de Carney, por lo que es importante siempre descartarlo. El tratamiento es la excisión quirúrgica, con alta probabilidad de recurrencia local, por lo que es fundamental el seguimiento post quirúrgico. A continuación presentamos el caso de un paciente de sexo masculino, de 60 años de edad, con un angiomixoma superficial preauricular, sin evidencia clínica ni imagenológica de componentes del complejo de Carney.

Superficial angiomyxoma are rare benign tumors with variable clinical presentations. They are located preferably in the trunk, limbs, and head and neck region. Histological diagnosis is relatively simple because there are specific features for this lesion. Superficial angiomyxomas may be a marker of cardiac myxomas and simultaneously be associated with Carney’s complex, so it is always important to consider this as a differential diagnosis. Treatment is surgical excision, with high probability of local recurrence, so post surgical follow-up is extremely important. We present the case of a male patient, 60 years old, with a preauricular superficial angiomyxoma with neither clinical nor radiological evidence of Carney’s complex components.

Caso clínico: síndrome de Baboon secundario a cuerpo extraño cutáneo / Case report: secondary Baboon syndrome to cutaneous foreign bodie

We report the clinical case of a 12 year-old healthy pediatric patient with a history of allergic contact dermatitis to nickel. He presented a papular symmetrical scarlatiniform rash after a gunshot impact partially withdrawn that began mainly in folds, which generalized to the rest of the body. We performed high-resolution ultrasonography in the impact area showing multiple small particles around a fibrous scar. The skin biopsy was consistent with systemic contact dermatitis, and immunofluorescence resulted negative. He was treated with prednisone for 5days and anti-TNF antihistamines with good results. Nickel contact dermatitis is common in clinical practice, but systemic contact dermatitis is less frequent and even less because of a foreign body, although it has already been described. The Baboon syndrome is a aculopapularitchy rash that begins in folds and then generalizes, one of its etiologies is nickel, it should be a type IV hypersensitivity that resolves spontaneously without scars.

Estudio de compromiso ocular en pacientes con rosácea / Ocular involvement in patients with cutaneous rosacea

La rosácea cutánea (RC) es una enfermedad crónica relativamente común que puede presentarse con afectación ocular. La rosácea ocular es considerada una enfermedad bilateral, manifestándose en la mayoría de los casos en forma simultánea al compromiso cutáneo. El objetivo del estudio es determinar el compromiso ocular de pacientes portadores de RC comparados con un grupo control y la asociación de severidad entre el compromiso cutáneo y el ocular. Se analizó un total de 112 pacientes; un primer grupo de 70 pacientes portadores de RC en un período de dos años, y el segundo constituido por 42 controles sanos. Observamos que en nuestros pacientes con RC hay una alteración de la función lagrimal y no existe relación estadísticamente significativa entre la severidad del compromiso cutáneo y el compromiso ocular. Debido a que el compromiso ocular en la RC es subestimado, es importante la evaluación de síntomas oculares en los pacientes con RC para continuar un manejo bidisciplinario entre dermatólogos y oftalmólogos.

Cutaneous rosacea (CR) is a relatively common chronic disease that can occur with ocular involvement. Ocular rosacea is considered a bilateral entity that usually manifests simultaneously with cutaneous disease. The objective of this study is to determine ocular involvement in CR patients, compared with a control group, and to establish the association between severity of cutaneous and ocular involvement. 112 patients were analyzed; a first group of 70 patients with a two year story of CR, and the second group consisting of 42 healthy controls. At the end of the study, we observed that patients with CR had tear dysfunction and there was no statistically significant relationship between the severity of cutaneous and ocular involvement. Since eye involvement in CR is underestimated, we consider it important to investigate ocular symptoms in patients with CR and maintain multi-disciplinary management between dermatologists and ophthalmologists.