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1.
Phys Rev Lett ; 119(21): 219901, 2017 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-29219399

RESUMO

This corrects the article DOI: 10.1103/PhysRevLett.115.133001.

2.
Phys Rev Lett ; 115(13): 133001, 2015 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-26451550

RESUMO

We present measurements of single-photon ionization time delays between the outermost valence electrons of argon and neon using a coincidence detection technique that allows for the simultaneous measurement of both species under identical conditions. The analysis of the measured traces reveals energy-dependent time delays of a few tens of attoseconds with high energy resolution. In contrast to photoelectrons ejected through tunneling, single-photon ionization can be well described in the framework of Wigner time delays. Accordingly, the overall trend of our data is reproduced by recent Wigner time delay calculations. However, besides the general trend we observe resonance features occurring at specific photon energies. These features have been qualitatively reproduced and identified by a calculation using the multiconfigurational Hartree-Fock method, including the influence of doubly excited states and ionization thresholds.

3.
Opt Express ; 22(22): 26967-75, 2014 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-25401846

RESUMO

We report on the first experiments characterizing the complete time-dependent 2D vector potential of a few-cycle laser pulse. The instantaneous amplitude and orientation of the electric field is determined with sub-cycle resolution, directly giving access to the polarization state of the pulse at any instant in time. This is achieved by performing an attosecond streaking experiment using a reaction microscope, where the full pulse characterization is performed directly in the target region.

4.
Rev Sci Instrum ; 85(10): 103113, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25362377

RESUMO

Here we present a successful combination of an attosecond beamline with a COLTRIMS apparatus, which we refer to as AttoCOLTRIMS. The setup provides either single attosecond pulses or attosecond pulse trains for extreme ultraviolet-infrared pump-probe experiments. We achieve full attosecond stability by using an active interferometer stabilization. The capability of the setup is demonstrated by means of two measurements, which lie at the heart of the COLTRIMS detector: firstly, we resolve the rotating electric field vector of an elliptically polarized few-cycle infrared laser field by attosecond streaking exploiting the access to the 3D momentum space of the charged particles. Secondly, we show streaking measurements on different atomic species obtained simultaneously in a single measurement making use of the advantage of measuring ions and electrons in coincidence. Both of these studies demonstrate the potential of the AttoCOLTRIMS for attosecond science.

5.
Rev Sci Instrum ; 85(10): 103117, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25362381

RESUMO

We present a simple electron time of flight spectrometer for time resolved photoelectron spectroscopy of liquid samples using a vacuum ultraviolet (VUV) source produced by high-harmonic generation. The field free spectrometer coupled with the time-preserving monochromator for the VUV at the Artemis facility of the Rutherford Appleton Laboratory achieves an energy resolution of 0.65 eV at 40 eV with a sub 100 fs temporal resolution. A key feature of the design is a differentially pumped drift tube allowing a microliquid jet to be aligned and started at ambient atmosphere while preserving a pressure of 10(-1) mbar at the micro channel plate detector. The pumping requirements for photoelectron (PE) spectroscopy in vacuum are presented, while the instrument performance is demonstrated with PE spectra of salt solutions in water. The capability of the instrument for time resolved measurements is demonstrated by observing the ultrafast (50 fs) vibrational excitation of water leading to temporary proton transfer.


Assuntos
Espectroscopia Fotoeletrônica/instrumentação , Soluções/química , Raios Ultravioleta , Vácuo , Calibragem , Desenho de Equipamento , Fatores de Tempo
6.
Rev Sci Instrum ; 85(1): 013113, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24517751

RESUMO

We present our attoline which is a versatile attosecond beamline at the Ultrafast Laser Physics Group at ETH Zurich for attosecond spectroscopy in a variety of targets. High-harmonic generation (HHG) in noble gases with an infrared (IR) driving field is employed to generate pulses in the extreme ultraviolet (XUV) spectral regime for XUV-IR cross-correlation measurements. The IR pulse driving the HHG and the pulse involved in the measurements are used in a non-collinear set-up that gives independent access to the different beams. Single attosecond pulses are generated with the polarization gating technique and temporally characterized with attosecond streaking. This attoline contains two target chambers that can be operated simultaneously. A toroidal mirror relay-images the focus from the first chamber into the second one. In the first interaction region a dedicated double-target allows for a simple change between photoelectron/photoion measurements with a time-of-flight spectrometer and transient absorption experiments. Any end station can occupy the second interaction chamber. A surface analysis chamber containing a hemispherical electron analyzer was employed to demonstrate successful operation. Simultaneous RABBITT measurements in two argon jets were recorded for this purpose.

7.
Neuroscience ; 210: 375-83, 2012 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-22421103

RESUMO

Lead intoxication has been suggested as a high risk factor for the development of Parkinson disease. However, its impact on motor and nonmotor functions and the mechanism by which it can be involved in the disease are still unclear. In the present study, we studied the effects of lead intoxication on the following: (1) locomotor activity using an open field actimeter and motor coordination using the rotarod test, (2) anxiety behavior using the elevated plus maze, (3) "depression-like" behavior using sucrose preference test, and (4) subthalamic nucleus (STN) neuronal activity using extracellular single unit recordings. Male Sprague-Dawley rats were treated once a day with lead acetate or sodium acetate (20 mg/kg/d i.p.) during 3 weeks. The tissue content of monoamines was used to determine alteration of these systems at the end of experiments. Results show that lead significantly reduced exploratory activity, locomotor activity and the time spent on the rotarod bar. Furthermore, lead induced anxiety but not "depressive-like" behavior. The electrophysiological results show that lead altered the discharge pattern of STN neurons with an increase in the number of bursting and irregular cells without affecting the firing rate. Moreover, lead intoxication resulted in a decrease of tissue noradrenaline content without any change in the levels of dopamine and serotonin. Together, these results show for the first time that lead intoxication resulted in motor and nonmotor behavioral changes paralleled by noradrenaline depletion and changes in the firing activity of STN neurons, providing evidence consistent with the induction of atypical parkinsonian-like deficits.


Assuntos
Intoxicação do Sistema Nervoso por Chumbo/fisiopatologia , Atividade Motora/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Norepinefrina/metabolismo , Núcleo Subtalâmico/efeitos dos fármacos , Animais , Ansiedade/induzido quimicamente , Depressão/induzido quimicamente , Intoxicação do Sistema Nervoso por Chumbo/metabolismo , Camundongos , Neurônios/metabolismo , Transtornos Parkinsonianos/metabolismo , Transtornos Parkinsonianos/fisiopatologia , Técnicas de Patch-Clamp , Ratos Sprague-Dawley , Núcleo Subtalâmico/metabolismo , Núcleo Subtalâmico/fisiopatologia
8.
East Mediterr Health J ; 15(1): 219-23, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19469446

RESUMO

Contamination of the operating theatre is a major cause of nosocomial infection. This study aimed to evaluate the incidence of bacterial contamination of operating theatres in Al Imam Ali Hospital in Baghdad, and the source of contamination. From 1216 swabs collected from surfaces, equipment and antiseptic solutions from different operating theatres in 2001 and 2002, the rates of positive cultures were 3.7% in 2001 and 4.0% in 2002. Staphylococcus epidermidis was the most common isolate in 2001 followed by Pseudomonas aeruginosa, whereas in 2002 coliform bacteria were the highest, followed by P. aeruginosa. No clear pattern of isolates was found in different types of operating theatres, although coliforms and P. aeruginosa were mostly found in the delivery theatre.


Assuntos
Anti-Infecciosos Locais , Contaminação de Medicamentos/estatística & dados numéricos , Contaminação de Equipamentos/estatística & dados numéricos , Salas Cirúrgicas , Causalidade , Infecção Hospitalar/microbiologia , Infecção Hospitalar/transmissão , Enterobacteriaceae/crescimento & desenvolvimento , Monitoramento Ambiental/métodos , Fômites/microbiologia , Hospitais Urbanos , Humanos , Incidência , Controle de Infecções , Iraque , Salas Cirúrgicas/estatística & dados numéricos , Pseudomonas aeruginosa/crescimento & desenvolvimento , Estações do Ano , Soluções , Staphylococcus epidermidis/crescimento & desenvolvimento
9.
(East. Mediterr. health j).
em Inglês | WHO IRIS | ID: who-117629

RESUMO

Contamination of the operating theatre is a major cause of nosocomial infection. This study aimed to evaluate the incidence of bacterial contamination of operating theatres in Al Imam Ali Hospital in Baghdad, and the source of contamination. From 1216 swabs collected from surfaces, equipment and antiseptic solutions from different operating theatres in 2001 and 2002, the rates of positive cultures were 3.7% in 2001 and 4.0% in 2002. Staphylococcus epidermidis was the most common isolate in 2001 followed by Pseudomonas aeruginosa, whereas in 2002 coliform bacteria were the highest, followed by P. aeruginosa. No clear pattern of isolates was found in different types of operating theatres, although coliforms and P. aeruginosa were mostly found in the delivery theatre


Assuntos
Infecção Hospitalar , Incidência , Staphylococcus epidermidis , Pseudomonas aeruginosa , Salas de Parto , Hospitais , Controle de Infecções , Salas Cirúrgicas
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