RESUMO
OBJECTIVES: The purpose of this study is to evaluate (a) health-related quality of life (HRQL) after vertical banded gastroplasty (VBG) (Mason) and (b) predictors of HRQL. SUBJECTS: Eighty-two consecutive patients were assessed preoperatively and then after 6, 12 and 24 months. Patients filled out questionnaires for subjective appraisal of HRQL (physical well-being, mood, physical performance, perceived health, social support and coping/adjustment). RESULTS: The greatest improvement in weight and HRQL was seen within 6 months of surgery. Twenty-four months after VBG weight reduction (P<0.05), perceived health (P<0.05), physical well-being (P<0.05), physical performance (P<0.05), mood (P<0.05), coping/adjustment (P<0.05) continued to be better than before surgery. Preoperative binge eating was the most important predictor of HRQL. CONCLUSION: Two years after VBG weight loss and a significant improvement of HRQL can be found. HRQL and weight loss are not associated in terms of outcome, indicating that weight loss alone may not be enough to improve HRQL.
Assuntos
Gastroplastia/psicologia , Obesidade/cirurgia , Qualidade de Vida , Adaptação Psicológica , Adolescente , Adulto , Idoso , Feminino , Gastroplastia/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: Previous studies indicate that sociocultural factors affect the course of pain disorder. We investigated the role of nationality as an indicator of cultural factors, and of the degree of inclusion (DI) in Swiss society as an indicator of the migration process on the course of pain disorder. METHOD: In a semiprospective case-control study, outcome was assessed after a 2-year follow-up in 57 patients treated for pain disorder by phone interview with the patients. One Swiss patient was matched with two Spanish or Italian patients living in Switzerland. Patients' appraisal of course of illness (PACI) and of current general health (PACGH) were assessed as the sum score of their ratings of general well-being, handicap in everyday life, work ability, mood and pain. Family physicians were also asked to rate patient's course of illness. DI in Swiss society was assessed according to type of work permit, age at immigration and fluency in the language of the receiving country. RESULTS: Swiss patients evaluated their PACI [H(1,56) = 4.30; P = .0038] and PACGH [H(1,56) = 9.04; P = .003)] more favourably than patients from Italy and Spain. This difference was confirmed by the family physician's evaluation of the course of illness. A similar difference in outcome was found in favour of foreign patients with a higher DI. CONCLUSION: These results indicate that, in addition to sociocultural factors, the DI affects the outcome of pain disorder in patients with a history of migration.
Assuntos
Emigração e Imigração , Transtornos Somatoformes/etnologia , Atividades Cotidianas , Adulto , Afeto , Estudos de Casos e Controles , Características Culturais , Feminino , Humanos , Itália/etnologia , Masculino , Pessoa de Meia-Idade , Apoio Social , Transtornos Somatoformes/psicologia , Transtornos Somatoformes/terapia , Espanha/etnologia , Suíça/etnologia , Resultado do TratamentoRESUMO
OBJECTIVE: The association of known prognostic factors with immune cell counts and beta2-microglobulin and soluble IL-2 receptor (sIL-2r) serum levels as markers of activation of the immune system was investigated in breast cancer. METHODS: Two hundred thirty five operated stage I and II breast cancer patients to receive adjuvant treatment in IBSCG trials were assessed in a cross-sectional study immediately before the first treatment. Leukocytes, lymphocytes and lymphocyte subset counts, beta2-microglobulin and sIL-2r serum levels were assessed as immunological parameters. Prognostic factors were tumor load, receptor status, patient characteristics, and contextual factors of the immune assessment (such as time of the day, time since surgery, type of surgery, concomitant medication, co-morbidity). RESULTS: In an operated early stage breast cancer patient population, tumor load was not associated with immune cell counts, beta2-microglobulin, or sIL-2r before adjuvant treatment. There was a pattern of association of prognostically favorable factors such as estrogen receptor (ER) positive tumor and older age with higher NK cell counts or with beta2-microglobulin or sIL-2r. In addition, immune cell counts and the markers of activation of the immune system were affected by several contextual factors, such as diurnal variability, time since surgery, type of surgery, and the intake of concomitant medication. CONCLUSIONS: The association of NK cell counts and beta2-microglobulin or sIL-2r serum levels with prognostically favorable factors such as ER positive tumor and older age supports the assumption that the immune system plays a role in the course of early breast cancer. The exact nature of this role requires further study.
Assuntos
Neoplasias da Mama/imunologia , Receptores de Interleucina-2/sangue , Microglobulina beta-2/sangue , Adulto , Idoso , Neoplasias da Mama/sangue , Quimioterapia Adjuvante , Estudos de Coortes , Estudos Transversais , Feminino , Humanos , Imunidade Celular , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Ensaios Clínicos Controlados Aleatórios como Assunto , SuíçaRESUMO
Morbid obesity (body mass index > 40 kg/m2) is a risk factor for cardiovascular, pulmonary, metabolic, neoplastic, and psychologic sequelae. In the present prospective clinical study 65 patients (11 men, 54 women) underwent vertical banded gastroplasty (Mason procedure) from June 1994 to October 1997. The median age was 41 +/- 5.3 years (range 18-69; n = 65). Preoperative body weight was 135 +/- 23 kg (96-229; n = 65), excess body weight in kg was 75 +/- 6.9 (44-155; n = 65) or in % 126 +/- 10 (78-223; n = 65) and BMI was 49 +/- 7.4 kg/m2 (39-69; n = 65). Mean hospital stay was 9.7 +/- 2.4 days (6-18; n = 65). Hospital mortality was 0% (0/65). Early complications were vomiting (30%) and problems in wound healing (15%; n = 65). Late complications (> 30 days) were incisional hernias (13.8%) and staple-line disruptions (12.3%; n = 65) with a reoperation rate of 23% (15/65). Median follow-up was 15.0 +/- 5.2 months (2-42) with a follow up rate of 100%. Mean weight loss after 12 months was 38.5 +/- 17 kg (30-98; n = 34) (P < 0.0001) and loss of excessive body weight 65 +/- 10% (57-86; n = 34), respectively (P < 0.0001). Cardiovascular risk factors (hypertension, diabetes, hyperlipidemia) were significantly improved within 12 months (n = 34). Vertical banded gastroplasty (Mason procedure)--well established for 20 years--is a good, safe therapy for morbid obesity if strict indications for operation are observed and if there is multidisciplinary long-term follow-up. Comorbid risk factors are considerably reduced and a long-term weight loss of more than 50% can be achieved without the risk of pathological metabolic changes.
Assuntos
Gastroplastia/métodos , Obesidade Mórbida/cirurgia , Complicações Pós-Operatórias/etiologia , Adolescente , Adulto , Idoso , Índice de Massa Corporal , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/diagnóstico , Estudos Prospectivos , Resultado do Tratamento , Redução de PesoRESUMO
The effects and interaction of endocrine and cytotoxic adjuvant treatment on measures of cellular immunity were assessed in 41 stage I-II breast cancer patients from International Breast Cancer Study Group trials. Counts of lymphocytes and lymphocyte subsets [(T, T4, T8, B, natural killer (NK) and activated T (AT) cells] were assessed by flow cytometry immediately before adjuvant therapy at baseline and on day 1 of the 3rd cycle. Twenty-two patients received cyclophosphamide, methotrexate and 5-fluorouracil (CMF), 7 CMF and tamoxifen (TAM), and 12 TAM alone. On day 1 of the 3rd cycle the counts of total lymphocytes (P = 0.003) and all lymphocyte subsets (P<0.05) except AT cells were significantly lower than baseline in the CMF treatment group. There was no significant change in the CMF+TAM or in the TAM treatment group. The combination of CMF and TAM resulted in less pronounced decrease in lymphocyte and subset counts from baseline to day 1 of the 3rd cycle. It seems possible that there is an interaction between TAM with CMF that affects lymphocyte and lymphocyte subset counts during cytotoxic treatment.
Assuntos
Antineoplásicos Hormonais/farmacologia , Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Subpopulações de Linfócitos B/efeitos dos fármacos , Neoplasias da Mama/imunologia , Subpopulações de Linfócitos T/efeitos dos fármacos , Tamoxifeno/farmacologia , Adulto , Idoso , Antineoplásicos Hormonais/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Quimioterapia Adjuvante , Cisplatino/efeitos adversos , Cisplatino/farmacologia , Cisplatino/uso terapêutico , Terapia Combinada , Interações Medicamentosas , Feminino , Citometria de Fluxo , Fluoruracila/efeitos adversos , Fluoruracila/farmacologia , Fluoruracila/uso terapêutico , Humanos , Metotrexato/efeitos adversos , Metotrexato/farmacologia , Metotrexato/uso terapêutico , Pessoa de Meia-Idade , Tamoxifeno/efeitos adversos , Tamoxifeno/uso terapêuticoRESUMO
Animal research has indicated that the activity of the hypothalamic-pituitary-adrenal axis can be influenced by classical (Pavlovian) conditioning procedures. To test the hypothesis that alterations in plasma cortisol levels can be conditioned in humans, the present study used a prospective, randomized, double-blind, placebo-controlled design in which a distinctively flavored beverage was paired with p.o. administration of dexamethasone. Twenty-five healthy men were randomly assigned to one of two groups. During the conditioning phase of the study, subjects in the experimental group received three conditioning trials (pairings of a distinctively flavored beverage with a capsule containing 5 mg dexamethasone) separated by 1 wk recovery periods. Subjects in the control group were treated identically, except that the capsule contained a placebo. During the test phase, all subjects underwent a test day (reexposure to the distinctively flavored beverage before receiving a placebo capsule) and a comparison day (no exposure to the beverage or the capsule). Plasma cortisol was assessed repetitively before and after administration of the beverage and capsule, as were possible confounding factors, including: behavioral variables, psychological distress, aversive reactions to the beverage, and expectations of treatment. After reexposure to the beverage and administration of a placebo capsule (conditioned stimuli), the experimental group had significantly higher levels of plasma cortisol than the control group, after controlling for variability in baseline levels of cortisol (F(5,60)=3.09; P=0.015) that could not be explained by differences in other study variables. No differences in cortisol levels were found on the comparison day. These results support the study hypothesis that changes in plasma cortisol levels can be classically conditioned in humans by pairing a distinctive beverage with p.o. administration of dexamethasone.
Assuntos
Condicionamento Clássico/efeitos dos fármacos , Condicionamento Clássico/fisiologia , Dexametasona/farmacologia , Glucocorticoides/farmacologia , Hidrocortisona/sangue , Adulto , Método Duplo-Cego , Humanos , Sistema Hipotálamo-Hipofisário/efeitos dos fármacos , Sistema Hipotálamo-Hipofisário/fisiologia , Masculino , Modelos Biológicos , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Sistema Hipófise-Suprarrenal/fisiologia , Estudos ProspectivosAssuntos
Comunicação , Neoplasias , Relações Médico-Paciente , Revelação da Verdade , Atitude do Pessoal de Saúde , Atitude Frente a Saúde , Cultura , Ética Médica , Feminino , Humanos , Masculino , Neoplasias/diagnóstico , Neoplasias/psicologia , Neoplasias/terapia , Participação do Paciente , Relações Profissional-Paciente , Prognóstico , Apoio Social , Assistência TerminalRESUMO
Relations among coping, physical symptoms, and affect were investigated in 43 women undergoing adjuvant chemotherapy for breast cancer. Patients were assessed at the same point in their treatment so that the time for which coping was reported would be equivalent across individuals. Patients were asked how they coped specifically with chemotherapy, rather than how they coped with cancer in general, to make the domain specific. Positive and negative affect were assessed separately, using a scale free of somatic content. Relations between coping and affect were consistent with prior studies that have employed a general approach to assessing coping. Coping correlates of positive and negative mood differed. When the relations between physical symptoms and affect were examined, physical symptoms were related to negative affect but not to positive affect. Findings are discussed in terms of their implications for coping with cancer as well as their implications for the general coping literature.
Assuntos
Adaptação Psicológica , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/psicologia , Tratamento Farmacológico , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Inquéritos e QuestionáriosRESUMO
Patients receiving cycles of cytotoxic chemotherapy for cancer often experience noxious side effects following treatments and may develop classically conditioned side effects, such as anticipatory nausea and vomiting (ANV) during the course of repeated infusions. The present study explored the possibility that classical conditioning processes may also contribute to treatment related psychological distress. Sixty-six patients, scheduled for adjuvant chemotherapy for breast cancer (stages I, II, IIIa), agreed to participate. Patients were assessed in the clinic on the first day of every chemotherapy cycle and in their homes three to five days before their final cycle. Patients experienced considerable psychological distress during the course of chemotherapy, and particularly before the first infusion. Prior to the last cycle of chemotherapy, psychological distress was significantly higher in the clinic environment than in patients' homes. Consistent with classical conditioning, psychological distress did not escalate over the days before treatment, but rather increased abruptly when patients returned to the clinic. The results of the present study indicate that several factors are involved in patients' anticipatory psychological distress and highlight the potential contribution that conditioning processes may make to patients' emotional distress in the clinic environment.