Pelvic exenterations for gynecologic cancers: A retrospective analysis of a 30-year experience in a cancer center.

INTRODUCTION: The objective of this study was to report a 30-year experience of PE for gynecologic malignancies in a cancer center. MATERIALS AND METHODS: A retrospective study was conducted at Institut Paoli-Calmette including patients who underwent PE for gynecologic malignancies. Four periods were evaluated: P1 before 1992, P2 between 1993 and 1999, P3 between 2000 and 2006 and P4 after 2006. The study evaluated the number of PE performed during each period, the type of PE, its level, indication, location of the primary tumor, patient age, previous radiotherapy ≥45 Gy, the rate of "curative" PE and exenteration-related reconstructive techniques. 90-day post-operative mortality and morbidity using the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) v 4.03 were reported. RESULTS: 277 PE were performed. The number of PE performed for recurrences rose during the study period (p = 0.042), PE performed for central tumors increased during P3 (64.4%) and P4 (67.4%) (p < 0.0001) and administration of radiotherapy ≥45 Gy was more frequent (p < 0.0001). The rate of "curative" PE increased (p < 0.0001). In multivariate analysis, "curative" PE were correlated with PE type, central locations and study period. Pelvic filling was progressively more frequently performed (p = 0.002). 90-day complication rate was 56.3%. In multivariate analysis there was a significant difference in distribution of CTCAE grade 3-4-5 morbidity depending on the period. Overall survival (OS) improved during the 2 last periods (p = 0.008). CONCLUSION: A better selection of eligible patients for PE, namely through improvement in imaging techniques, has enabled to raise the rate of curative PE.

[HPV prophylactic vaccine coverage and factors impacting its practice among students and high school students in Marseilles' area]. / Vaccination anti-HPV : évaluation de la couverture vaccinale et des facteurs qui l'influencent chez les lycéennes et étudiantes de la région PACA.

OBJECTIVES: To assess the coverage of HPV vaccine among young women from Marseilles' area and factors influencing the probability of this vaccination. MATERIALS AND METHODS: An anonymous survey was conducted among 2124 high school and university students from Marseilles' area, France from December 2011 to May 2012. RESULTS: Mean age of participants was 20.4years (±SD: 3.3). Only 41.6% participants reported being vaccinated against HPV, of whom 768 (93.3) had completed the 3 injections scheme. Among non-vaccinated respondents, 33.6% acknowledged they would accept a catch-up vaccination. Factors influencing the probability of being vaccinated were young age (AOR: 0.728; 95% CI: 0.681-0.779; P<0.001), socioeconomic and/or education level of parents (AOR: 1.324; 95% CI: 1.006-1.742; P=0.045), information about vaccination (AOR: 24.279; 95% CI: 5.417-108.82; P<0.001) and having a general practitioner (GP) favourable to vaccination (AOR: 68.776; 95% CI: 34.511-137.061; P<0.001). Factors influencing the probability to accept a catch-up vaccination were age (AOR: 1.059; 95% CI: 1.001-1.120; P=0.046), socioeconomic and/or education level of parents (AOR: 1.637; 95% CI: 1.198-2.237; P=0.002) and having a GP favourable to vaccination (AOR: 4.381; 95% CI: 2.978-6.445; P<0.001). Only 35.5% of respondents were aware that screening remains necessary following HPV vaccination. CONCLUSION: The coverage of HPV vaccine among young women from Marseilles' area is insufficient. Factors influencing the probability of being vaccinated against HPV are age, socioeconomic and/or education level of parents and information regarding vaccination. GP plays a major role in the acceptance of HPV vaccine.

[Predictive factors for vaginal birth after cesarean section]. / Quels facteurs influencent la voie d'accouchement en cas de tentative de voie basse sur utérus cicatriciel ?

OBJECTIVES: Determination of predictive factors of vaginal delivery in women with a history of caesarean section undergoing a trial of labor. MATERIALS AND METHODS: Relevant studies were identified through Medline, and the Cochrane databases 1980-2012. Recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: In France in 2010, a trial of labor was attempted in 49 % with 75 % successful rate (EL2). The site of delivery does not appear to influence the rate of successful trial of labor (EL3). Two factors are strongly associated with vaginal birth after caesarean (VBAC): prior history of vaginal delivery and spontaneous labor (EL2). Many factors appear to decrease the rate of VBAC: maternal age above 40 years (EL3), body mass index greater than 30 kg/m(2) (EL3), birth weights greater than 4000 g (EL3), unfortunately, prediction of macrosomia seems to be inaccurate. Induction of labor with pharmacological (prostaglandins and oxytocin) and mechanical methods (Foley catheter) decreased rate of successful VBAC (EL2). The use of pelvimetry to accept or avoid trial of labor, increase the risk of elective caesarean section (EL2) and should therefore not be recommended (grade C). Nomograms are not accurate to predict fail trial of labor as its clinical relevance is limited and has not yet evaluated in French population (expert opinion). CONCLUSION: After caesarean, trial of labor is associated with 75 % successful rate. Two factors are strongly associated with VBAC: a prior history of vaginal delivery and spontaneous labor.

[HPV prophylactic vaccine coverage in France: Results of a survey among high school and university students in Marseilles' area]. / Évaluation de la couverture vaccinale du vaccin anti-hpv : résultats d'une enquête auprès des lycéennes et étudiantes de la région PACA.

OBJECTIVE: To assess HPV prophylactic vaccine coverage among French high school and university students as well as their level of education about this vaccine. PATIENTS AND METHODS: An anonymous survey was conducted among 2500 high school and university students from the area of Marseilles, France, from December 2009 to April 2010. RESULTS: A total of 2018 questionnaires were collected (80.7% participation rate). Mean age of participants was 20 years (range, 15-45 years). Only 671 (35.4%) participants reported having been vaccinated against HPV, of whom 510 (73.4%) had completed the three injections scheme. Practice of cytological cervical cancer screening was not significantly influenced by vaccination status. Thus, 578 (45.2%) participants who had not been vaccinated already had had a cervical cytology performed, versus 295 (43.3%) vaccinated ones (P=0.445). Among those not being vaccinated, 671 (49.8%) fulfilled criteria for a catch-up vaccination, of whom only 325 (48.4%) agreed for such a catch-up. Main reasons given for refusal for a catch-up vaccination were the lack of information about HPV vaccine and fear of side effects. In total, 1722 (90%) considered themselves as educated about the HPV vaccine. Source of education was attributed to doctors and media by 54.4% and 53.7% of participants, respectively. Educational role attributed to school and university was poor (3.4%). CONCLUSION: Despite apparent satisfactory level of education, HPV prophylactic vaccine coverage among high school and university students appears to be insufficient.