[Analysis of pregnancy, labor, child development and disease course in women with Hodgkin's disease]. / Analiza ciaz, porodów, urodzonych dzieci i przebiegu choroby u kobiet chorych na ziarnice zlosliwa.

Twenty pregnancies were observed in 16 women with Hodgkin's disease. During 3 pregnancies cytostatic treatment was given. In 6 cases the disease was diagnosed in pregnancy and the treatment was started after labour. Eleven pregnancies were diagnosed during remission, after a mean period of 4 years (range: 6 months to 8 years) from the completion of treatment. All pregnancies had a normal course and labours were not complicated. In 2 cases of successive pregnancies disease recurrence developed. in 1 case the active disease was exacerbated. Twenty healthy babies were born, in one low birth weight was noted. The development of all children in a period of 6 years, on average, was normal.

[Treatment of low-malignancy lymphomas by spleen irradiation]. / Leczenie chloniaków o malej zlosliwosci napromienianiem sledziony.

The spleen was irradiated in 8 patients with chronic lymphatic leukaemia using RTG radiation in doses of 225 to 800 cGy for one treatment course. The follow-up after radiotherapy lasted 12.5 months on average. In 7 cases a considerable reduction was observed in the size of the spleen, and in 6 cases the absolute leucocyte and lymphocyte counts decreased by a mean of 46% and 50% respectively. In patients in late phase of the disease the improvement was short-lasting; 5 patients died (2 from infectious complications). In patients in early phase remissions of 30 months were obtained with normalization of the proportions or T and B cells During the radiotherapy a significant rise was observed in the per cent of granulocytes and a fall of albumin level. Increased gamma-globulin and uric acid levels and decreased hemoglobin level and erythrocyte count were not significant. Variable changes were noted in the platelet count. No bleeding tendency was noted. Spleen irradiation may be used in the treatment of non-Hodgkin lymphoma associated with malignant proliferation prevailing in the spleen, that is in chronic prolymphocytic leukaemia and hairy-cell leukaemia Favourable effects of spleen irradiation were observed in chronic lymphatic leukaemia and this induced us to use this method in our eight cases.

[Clinical and hematological analysis of acute granulocytopenia]. / Analiza kliniczna i hematologiczna ostrych granulocytopenii.

Retrospective analysis of 13 patients treated for the acute granulocytopenia at the Institute of Haematology for the last 10 years was carried out. Drugs were the most common causative factor. Comparing the results of the similar analysis several years ago in which the significant role was played by chloramphenicol, non-steroidal anti-inflammatory agents were the main cause. Infective complications were seen in all analysed patients. Broad spectrum antibiotics were used in all patients. Glycocorticosteroids were given to 9 patients while leucocytic concentrates to 7 patients. Remission was achieved in 12 patients, one female patient with the history of exposition to plant protection agents and increased levels of chlorinated aromatic hydrocarbons--died. Intensive antibacterial therapy significantly lowered mortality of the analysed patients in comparison with the similar group analysed earlier. Recurrence of granulocytopenia was seen in 5 patients following the contact with causative agent. Recurrencies were finished with remission.