Linfoma de células en anillo de sello que simula carcinoma mucosecretante / Signet ring cell lymphoma mimicking mucin-producing carcinoma

Signet ring cell lymphoma is a rare neoplasm characterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharyngeal mucosa is reported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+), CD45(+), CD20(+), Ig M(+), Kappa chain(+) and high index proliferative activity of neoplastic cells (Ki 67:70%). After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.

El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensenciade grandes células de citoplasma vacuolado, claro, similar a los encontrados en adenocarcinomasmucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta el casode un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe.Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%). El paciente evolucionó desfavorablemente y falleció a los dosmeses del diagnóstico sin recibir tratamiento.

Linfoma de células en anillo de sello que simula carcinoma mucosecretante / Signet ring cell lymphoma mimicking mucin-producing carcinoma

Signet ring cell lymphoma is a rare neoplasm characterized by large, vacuolated and clear cells mimicking mucin-producing adenocarcinoma. It is localized in nodal and extranodal sites. A case of a 59 years old male, with a diffuse lymphoma signet ring cell type localized on oropharyngeal mucosa is reported. The histopathology study showed signet ring cells and the immunophenotype was: vimentine(+), CD45(+), CD20(+), Ig M(+), Kappa chain(+) and high index proliferative activity of neoplastic cells (Ki 67:70%). After a review of the literature and previous reports, we could not find a similar case in this anatomic site. The patient had a unfavourable clinical course and died two months after the diagnosis without receiving any treatment.(AU)

El linfoma de células en anillo de sello es una neoplasia poco frecuente, caracterizada por la presensenciade grandes células de citoplasma vacuolado, claro, similar a los encontrados en adenocarcinomasmucosecretantes. Se ha descripto en ganglios linfáticos y tejidos extralinfáticos. Se presenta el casode un paciente varón de 59 años con linfoma de células en anillo de sello localizado en pared lateral de orofaringe.Esta localización creemos que no ha sido descripta anteriormente. La histología mostró células en anillo de sello y el inmunofenotipo tumoral fue: vimentina, CD45, CD20, Ig M y cadenas kappa positivos, siendo la fracción de crecimiento tumoral alta (Ki 67:70%). El paciente evolucionó desfavorablemente y falleció a los dosmeses del diagnóstico sin recibir tratamiento.(AU)

[Specific prostatic antigen in prostatic carcinoma: its relationship with tumor differentiation and clinical course]. / Antígeno prostático específico en el carcinoma de próstata: su relación con la diferenciación tumoral y la evolución clínica.

Carcinoma of the prostate is a tumor with a variable clinical course and a high incidence of local progression and/or metastasis. This study was undertaken to evaluate tissue prostate specific antigen (PSA) in patients with carcinoma of the prostate, its correlation with Gleason's grading and its value in predicting the clinical course of these patients. We studied 28 transurethral biopsies of patients with prostatic carcinoma utilizing HE and peroxidase-antiperoxidase staining techniques. These were given a score of 2 to 10 using Gleason's grading. PSA was determined according to percent positivity. The clinical course was considered favourable (F) when the lesion remained stable and unfavourable (U) when peri-prostatic spread was evidenced, metastasis and/or death from the disease. Statistical analysis was performed with the linear discriminatory test. PSA percentages ranged from 0 to 95 and the Gleason score from 3 to 11. There was an indirect correlation between these methods (r = 0.74): high Gleason scores corresponded to low PSA values and viceversa. PSA was highly positive in patients with F and U clinical courses whereas low positive values (less than 40%) were observed only in patients with U clinical course. High Gleason (8 to 10) and low (less than 5) scores were observed only in patients with a clinical course of U or F, respectively, while intermediate values (5 to 8) were not predictive of the clinical course. Discriminatory analysis gave Z values of -2.446 (P = 0.014) for PSA, -2.90 (P = 0.004) for the Gleason score in predicting prognosis, conferring a greater value overall to the latter.(ABSTRACT TRUNCATED AT 250 WORDS)

[Intratubular neoplasm adjacent to germ cell tumor of the testis]. / Neoplasia intratubular adyacente a tumor germinal de testículo.

Because intratubular germ cell neoplasia (IGCN) is considered to be a precursor of testicular cancer, precise identification of this tumor type is important. The present study was undertaken to determine the cytological features of IGCN, its histological classification, and its incidence relative to other invasive germ cell tumors. We studied the biopsy specimens from a similar number of patients. The biopsy material was fixed in formol and embedded in paraffin. Sections were processed and analyzed with the hematoxylin-eosin and PAS stainings methods with and without diastase. IGCN classification was performed following the criteria recommended at the International Symposium on Testicular Cancer (Minneapolis, 1980). IGCN was recognized in 22 (26%) of the 85 biopsies and presented the following characteristic features; large cells with hyperchromatic nuclei, one or more nucleoli and abundant cytoplasm. Glycogen was present in most of the lesions but not in controls. In 12 patients (54.5%), the cytological anomaly was observed in the periphery of the tubules without the characteristic features of germ cell tumors. This lesion type was termed "unclassified". In 5 cases (22.7%), the tubule lumen was filled with atypical cells with round nucleus, scant chromatin, prominent nucleolus and scant cytoplasm. This variety was termed "intratubular seminoma". In 2 cases (9%) the intratubular lesion revealed large cells with pleomorphic nucleus and central necrosis. This variety was called "intratubular embryonal carcinoma".(ABSTRACT TRUNCATED AT 250 WORDS)