RESUMO
The authors present complex hygienic characteristics of work conditions for workers engaged into metallurgic process of ferrovanadium production. Chemical factors were shown as having complex influences. Occupational risk for the workers' health was estimated. Categories of a priori occupational risk for workers are valued from average (considerable) risk to very high (intolerable) risk. Factors that are priorities for development of occupationally induced diseases are disclosed. Reliable cause-effect relationships between working environment factors and the workers' diseases are determined. Work conditions appeared to play considerable role in respiratory tract diseases (average degree of occupational conditionality). Differences between workshops in fractional composition and concentration of dust, as major components of occupational factors complex, develop pathologic changes in various levels of respiratory system.
Assuntos
Poluentes Atmosféricos/toxicidade , Metalurgia , Doenças Profissionais/epidemiologia , Doenças Respiratórias/epidemiologia , Aço/toxicidade , Compostos de Vanádio/toxicidade , Adulto , Poeira , Humanos , Doenças Profissionais/induzido quimicamente , Doenças Respiratórias/induzido quimicamente , Risco , Recursos Humanos , Local de TrabalhoRESUMO
The article covers prevalence of risk factors concerning cardiovascular diseases and health disorders in workers due to occupational hazards of textile production, criteria for early diagnosis of arterial hypertension. To prevent arterial hypertension and its progress into severe cardiovascular diseases in the workers, the authors necessitated complex of medical and preventive measures.
Assuntos
Doenças Cardiovasculares/diagnóstico , Doenças Profissionais/diagnóstico , Indústria Têxtil , Adulto , Doenças Cardiovasculares/prevenção & controle , Diagnóstico Precoce , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/prevenção & controle , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Doenças Profissionais/prevenção & controle , Fatores de Risco , Recursos HumanosRESUMO
Features of diurnal profile of blood pressure in workers having serum level of benzol and ethylbenzene are high systolic and diastolic arterial blood pressure during the day, index of systolic arterial pressure time and index diastolic arterial pressure time was also high. These features should be considered in anti-hypertensives prescription.
Assuntos
Anti-Hipertensivos/administração & dosagem , Ritmo Circadiano/efeitos dos fármacos , Hidrocarbonetos Aromáticos , Hipertensão , Monitorização Fisiológica/métodos , Exposição Ocupacional/efeitos adversos , Adulto , Pressão Sanguínea/efeitos dos fármacos , Determinação da Pressão Arterial/métodos , Indústria Química , Cronofarmacoterapia , Feminino , Humanos , Hidrocarbonetos Aromáticos/sangue , Hidrocarbonetos Aromáticos/toxicidade , Hipertensão/diagnóstico , Hipertensão/etiologia , Hipertensão/fisiopatologia , Hipertensão/prevenção & controle , Masculino , Conduta do Tratamento Medicamentoso , Pessoa de Meia-Idade , Fatores de Risco , Fatores de TempoRESUMO
The authors evaluated influence of phenol, o-cresol, m-cresol and p-cresol on cellular immunity in apparatus operators engaged into chemical production. Detection covered significant membrane and intracellular markers characterizing peculiarities of cellular immune reactions in contamination with phenols (CD4+ deficit, hyperproduction of FoxP3 and CD25+).
Assuntos
Antígenos CD/sangue , Indústria Química , Fatores de Transcrição Forkhead/sangue , Tolerância Imunológica/efeitos dos fármacos , Exposição Ocupacional/efeitos adversos , Fenóis , Adulto , Biomarcadores/sangue , Feminino , Humanos , Imunidade Celular/efeitos dos fármacos , Masculino , Pessoa de Meia-Idade , Monitorização Imunológica/métodos , Fenóis/sangue , Fenóis/toxicidadeRESUMO
Workers exposed to aromatic hydrocarbons appeared to have prevalence of heterozygous variants of CYP1A1 gene (9893 A/G) and tumor necrosis factor gene reliably higher vs. the reference group 2.5 and 3.3 times respectively, and level of anti-benzene antibodies (IgG) increased vs. the reference group. The data presented demonstrate negative immunogenetic associations of aromatic hydrocarbons influence on oil extraction operators.
Assuntos
Citocromo P-450 CYP1A1/genética , Hidrocarbonetos Aromáticos , Tolerância Imunológica/efeitos dos fármacos , Imunoglobulina E/sangue , Exposição Ocupacional/efeitos adversos , Fator de Necrose Tumoral alfa/genética , Adulto , Biomarcadores/sangue , Biotransformação/efeitos dos fármacos , Indústrias Extrativas e de Processamento , Feminino , Marcadores Genéticos , Humanos , Hidrocarbonetos Aromáticos/sangue , Hidrocarbonetos Aromáticos/toxicidade , Imunidade Celular/efeitos dos fármacos , Imunidade Humoral/efeitos dos fármacos , Masculino , Monitorização Imunológica/métodos , Polimorfismo Genético/efeitos dos fármacosRESUMO
The goal of the investigation was to detect and assess the specific features of abnormal biochemical and immunological parameters in children living in the industrially developed areas in order to solve the tasks of early diagnosis and to enhance the efficiency of prevention of the chronic pattern of gastroduodenal diseases. It was found that children with increased contamination of biological media had more active inflammatory reactions with a trend towards the chronic pattern of an inflammatory process, altered antioxidant defense and a more common chronic inflammatory process in the biliary tract, and more significant cytolysis syndrome with gallbladder concentration dysfunction.
