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1.
J Chromatogr Sci ; 56(1): 6-17, 2018 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-28977362

RESUMO

Almotriptan maleate (ALMT), a highly selective 5-hydroxy tryptamine 1B/1D (5-HT1B/1D) receptor agonist used in the treatment of migraine headache was subjected to various ICH (Q1A (R2)) specified guidelines. The drug underwent significant degradation under hydrolytic (acid, base and neutral), oxidative and photolytic stress conditions, while it was stable under thermal stress condition. A total of seven significant degradation products (DPs) were obtained. A simple, selective and reliable UPLC method has been developed for the separation of ALMT and its DPs using Acquity UPLC HSS Cyano (100 × 2.1 mm, 1.8 µm) column with mobile phase consisting of ammonium acetate (10 mM, pH 4.4) buffer and acetonitrile in gradient elution mode. Chromatographic analysis was performed at a flow rate of 0.3 mL/min using a PDA detector at a wavelength of 230 nm. All the DPs (DP-1 to DP-7) were characterized using UHPLC-ESI-QTOF based on mass fragmentation pattern and accurate m/z values. The developed UPLC method was validated in terms of specificity, linearity, precision and accuracy. The developed stability-indicating method helps in quantification of drug in the presence of DPs.


Assuntos
Cromatografia Líquida de Alta Pressão/métodos , Cromatografia de Fase Reversa/métodos , Espectrometria de Massas em Tandem/métodos , Triptaminas/análise , Triptaminas/química , Estabilidade de Medicamentos , Hidrólise , Limite de Detecção , Modelos Lineares , Reprodutibilidade dos Testes
2.
Acta Orthop Belg ; 82(4): 907-912, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29182138

RESUMO

Osteopetrosis is a rare hereditary condition which may have autosomal recessive or autosomal dominant inheritance. Patients tend to present most commonly with fractures but involvement of cranial nerves and hematopoetic system is not uncommon. Patients with infantile and intermediate type tend to present more often with problems other than orthopaedic problems. While diagnosis can be made on the basis of radiographs, management needs to be customized for every patient. Non operative and operative management both have their advantages and disadvantages. We are here reporting a case of sub-trochanteric fracture in an eight-year-old child which was managed successfully with a dynamic hip screw (DHS). Surgery could be performed successfully by taking precautions during reduction, drilling and screw placement. At the latest follow up, which was after one and half years of surgery, the fracture had united well and the child faced no limitations of activities. Thus, open reduction and fixation with DHS can be considered as an effective management modality for pediatric sub-trochanteric fractures in osteopetrosis.


Assuntos
Ciclismo/lesões , Fraturas do Fêmur/cirurgia , Fraturas do Quadril/cirurgia , Osteopetrose/diagnóstico por imagem , Acidentes por Quedas , Parafusos Ósseos , Criança , Fraturas do Fêmur/complicações , Fraturas do Fêmur/diagnóstico por imagem , Fraturas do Quadril/complicações , Fraturas do Quadril/diagnóstico por imagem , Humanos , Masculino , Osteopetrose/complicações , Radiografia , Resultado do Tratamento
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