Surgical wound infections after vascular surgery: prospective multicenter observational study.

BACKGROUND AND AIMS: this multicenter prospective observational study defined the incidence and risk factors of surgical wound infections (SWI) after infrarenal aortic and lower limb vascular surgery procedures and evaluated the severity and costs of these infections. METHODS: the study cohort comprised of 184 consecutive patients. Postoperative complications were recorded. The additional costs attributable to SWI were calculated. RESULTS: Eighty-four (46%) patients had critical ischaemia, 81 (45%) patients underwent infrainguinal bypass surgery and 64 (35%) received vascular prosthesis or prosthetic patch. Forty-nine (27%) patients developed SWI. Staphylococcus aureus was the leading pathogen cultured from the wound. Forty-seven of the 49 infected wounds responded to and healed with the treatment. SWI was the cause of one major amputation. Independent predictors for SWI were infrainguinal surgery (OR 7.2, 95% Cl 2.92-17.65, p < 0.001), obesity (OR 6.1, 95% Cl 2.44-15.16, p < 0.001) and arteriography injection site within the operative area (OR 2.5, 95% Cl 1.13-5.48, p = 0.02). The average cost attributable to SWI was 3320 Ä. CONCLUSION: the incidence of SWI after vascular surgery is high. The risk factors for SWI are infrainguinal surgery, obesity and arteriography injection site within the operative area. SWI increases morbidity and costs of operative treatment.

Modified ankle-brachial index detects more patients at risk in a Finnish primary health care.

OBJECTIVES: Despite peripheral arterial disease (PAD), defined as ankle-brachial index (ABI)or=70 years or calf pain during exercise. A total of 817 patients were recruited. METHODS: Research methods included interview and Doppler measurement of brachial and ankle pressures. RESULTS: An ABI(mod)or=1.4 had the strongest association with CVD. CONCLUSIONS: PAD is highly prevalent among patients presenting to primary care. ABI(mod) calculation detects more number of patients at risk at the cost of reduced specificity. The association of high ABI with CVD noted in this study warrants future research for validation.

Brain diffusion changes in carotid occlusive disease treated with endarterectomy.

BACKGROUND: Patients with unilateral high-grade carotid stenosis or occlusion have been reported to have more leukoaraiosis and ischemic lesions in ipsilateral than in contralateral cerebral hemisphere. The lesions alter apparent diffusion coefficient (ADC) values in diffusion-weighted MRI (DWI). The overall effects of carotid endarterectomy on ADC values have not yet been explored. OBJECTIVE: S: To find out whether 1) average ADC (ADC(av)) values differed between hemispheres, 2) diffusion changes induced by carotid endarterectomy could be detected in brain tissue with serial DWI, and 3) patients with asymptomatic carotid stenosis differed from patients with a symptomatic stenosis. METHODS: Forty-five patients (22 with asymptomatic carotid stenosis and 23 with symptomatic carotid stenosis) with unilateral high-grade carotid stenosis underwent DWI before carotid endarterectomy and 3 and 100 days afterward, and 45 age- and sex-matched healthy control subjects were imaged once. We evaluated ADC(av) values in normal-appearing gray and white matter, watershed regions (WsR), and thalamus. RESULTS: ADC(av) values of ipsilateral white matter and WsR were higher than those of contralateral white matter and WsR, both being higher than in white matter and WsR of control subjects. After carotid endarterectomy, these differences were diminished, but the levels remained higher than in controls. ADC(av) values of gray matter and thalamus remained unaffected. Asymptomatic carotid stenosis and symptomatic carotid stenosis patient groups did not differ from each other. CONCLUSIONS: Carotid stenosis has an effect on diffusion in the white matter of the ipsilateral hemisphere, and it is partly reversible by carotid endarterectomy. The finding may be associated with leukoaraiotic development ("preleukoaraiosis").

Adhesion molecule expression in symptomatic and asymptomatic carotid stenosis.

BACKGROUND: Prior studies have suggested a central role for cellular adhesion molecules (CAMs) in the pathophysiology and symptoms of atherosclerotic carotid plaques (CPs). OBJECTIVE: This study examined the role of CAMs in symptom generation in patients with advanced carotid artery disease. METHODS: Ninety-two consecutive patients underwent carotid endarterectomy, six for both sides (54 symptomatic and 41 asymptomatic CPs). Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin were immunostained in fresh-frozen CP specimens and examined semiquantitatively in the endothelium and intima-media. Plasma concentrations of soluble ICAM-1 and sVCAM-1 were analyzed by ELISA. RESULTS: Endothelial expression of ICAM-1, VCAM-1, P-selectin, and E-selectin did not differ between symptomatic and asymptomatic CPs, but endothelial ICAM-1 was associated with serum sensitized C-reactive protein levels (p = 0.026). However, there was less ICAM-1 expression in the intima-media of the symptomatic CPs (p = 0.022), and there was a similar, but nonsignificant tendency for VCAM-1. Soluble ICAM-1 and soluble VCAM-1 were not associated with the symptom status. CONCLUSIONS: In contrast to earlier studies, it was found that symptomatic carotid disease is not associated with increased expression of adhesion molecules in the endothelium of advanced carotid plaques or in circulation. Rather, there was less expression of adhesion molecules in the intima-media of symptomatic carotid plaques.

Cerebral cast angiography as an aid to medicolegal autopsies in cases of death after adult cardiac surgery.

Due to an increase in age of the patient population in cardiac surgery, cerebral complications are increasing in frequency, also as a cause of death. In order to reveal cerebral pathology associated with a fatal outcome after cardiac surgery, we re-evaluated the cast angiographs and medico-legal autopsy documents of 144 adult cardiac surgery subjects over a 7-year period. Special attention was paid to the ability of post-mortem cast angiography to aid in diagnosing cerebral pathology. The autopsy detected new ischemic cerebral lesions in 29 (20%) cases, of which 22 (15.3%) were recent infarcts, and 7 were cases of anoxic brain damage. Of the recent cerebral infarcts, 12 were associated with cerebral artery thrombosis, 4 showed multiple lesions, and the remaining 6 were small single infarcts. In addition, one subject had an intracerebral hemorrhage and 72 (50%) cerebral edema. By cast angiography, the leakage of contrast medium in the case of intracerebral hemorrhage and stenoses of intracranial and cervical arteries could be well demonstrated and also revealed 17 (77%) of the 22 recent cerebral infarcts. It was found to be suitable for detecting recent brain infarcts associated with main cerebral artery thrombosis, with a sensitivity of 92% (11 out of 12 cases), but was less sensitive in showing small recent infarcts with a sensitivity of 60% (6 out of 10 cases) and inferior for the older ones where none of the 6 cases were detected. Filling defects caused by cerebral edema were difficult to differentiate from technical errors and were encountered in 7 (4.8%) cases. A significant predictor for the 29 recent ischemic brain lesions was perioperative hypotension. The immediate cause of death was most often of cardiac (83%) and cerebral (14%) origin. In 14 cases, cerebral damage was considered to be an additional cause of death. The use of cerebral post-mortem cast angiography should be recommended, especially for its excellent ability to visualize intravascular pathology such as arterial stenoses and thromboses, with a 92% sensitivity in showing new main cerebral artery thromboses, before likely distortion of the vascular anatomy by dissection.

Perioperative stroke in coronary artery bypass surgery. Analysis of risk factors.

The incidence of neurologic complications after coronary bypass surgery is steadily rising as older and sicker patients are increasingly being treated. To identify patients requiring special attention, we reviewed the records in 2263 consecutive cases of first-time coronary artery bypass grafting in 1993-1995, in order to find predictive factors for stroke. Significant factors in univariate analysis were patient age, peripheral vascular disease, cerebrovascular disease, renal failure (defined as serum creatinine > or = 150 micromol/l), aneurysmal disease of the abdominal aorta, stenosis of the left main coronary artery, urgent or emergency operation, NYHA class, cardiopulmonary bypass time, number of aortic anastomoses, intraoperatively detected loose or calcified atheromatosis of the ascending aorta, left ventricular venting, intra-aortic balloon counterpulsation, cardiac complications necessitating early reoperation, and perioperative myocardial infarction. In a multivariate analysis, age, renal failure, cerebrovascular disease, peripheral vascular disease, NYHA class, number of aortic anastomoses, perioperative myocardial infarction and intraoperatively detected loose atheromatosis of the ascending aorta remained significant.

Infrarenal endoluminal bifurcated stent graft infected with Listeria monocytogenes.

Prosthetic graft infection as a result of Listeria monocytogenes is an extremely rare event that recently occurred in a 77-year-old man who underwent endoluminal stent grafting for infrarenal abdominal aortic aneurysm. The infected aortic endoluminal prosthesis was removed by means of en bloc resection of the aneurysm and contained endograft with in situ aortoiliac reconstruction. At the 10-month follow-up examination, the patient was well and had no signs of infection.

Risk factors for ascending aortic atheromatosis--a retrospective analysis of 2,263 patients undergoing coronary artery bypass surgery.

BACKGROUND AND AIMS: Ascending aortic atherosclerosis has been recognised as a potential source of atheroembolization during coronary artery bypass operation. A set of possible predictive preoperative factors for ascending aortic atheromatosis was studied to find the patients at greatest risk for aortic atheromatosis. MATERIAL AND METHODS: The records of 2,263 patients undergoing first-time coronary bypass operation from January 1993 to December 1995 were reviewed. Ascending aortic atheromatosis was considered to be present if the operating surgeon detected atheromatosis in ascending aorta by palpation or by sight while making aortotomies. RESULTS: Ascending aortic atheromatosis was found in 9.1% of the patients. Significant predictors in the multivariate model were age, tobacco use, diabetes, peripheral vascular disease, renal failure, chronic obstructive pulmonary disease, x-ray calcifications of the thoracic aorta and subclavian artery stenosis at minimum 50 %. The loose variety of atheromatosis was detected by sight while making aortotomies in 1.1% of patients. Significant predictors in the multivariate model for this loose variety were age, hyperlipidemia and renal failure. Patients with ascending aortic atheromas suffered significantly more perioperative myocardial infarcts and central neurological defects as well as succumbed more often. CONCLUSION: This study defines some groups of coronary bypass patients that have increased risk for ascending aortic atheromatosis. Special attention should be paid to them during coronary bypass operation in order to minimise the otherwise increased risk for adverse neurological and cardial outcome.