Mesiodistal angulation and faciolingual inclination of each whole tooth in 3-dimensional space in patients with near-normal occlusion.

INTRODUCTION: An important objective of orthodontic treatment is to obtain the correct mesiodistal angulation and faciolingual inclination for all teeth. Current techniques are based on crown angulation and inclination standards, and not enough attention has been given to the roots. In this study, we report the mesiodistal angulation and faciolingual inclination of each whole tooth including the root in patients with near-normal occlusion. METHODS: We screened 1840 patients who had cone-beam computed tomography scans taken before treatment to obtain a sample of 76 patients with near-normal occlusion. Using our custom University of Sourthern California root vector analysis software program, we digitized the crown and root centers to determine the "true" long axis of each tooth from where the mesiodistal angulation and the faciolingual inclination were measured. RESULTS: The means and standard deviations for the mesiodistal angulation and the faciolingual inclination of each whole tooth were calculated. The maxillary angulations of the teeth started from approximately 6° for the central incisors, slightly increased for the lateral incisors, and peaked at 11° for the canines; then it gradually decreased to just above 0° for the first molars and eventually reached -6° for the second molars. The mandibular angulations started from about 0° for the incisors and increased to 17.5° for the second molars. The maxillary inclination was the highest at 33.5° for the central incisors, decreased to about 0° at the second premolars, and then increased for the 2 molars. The mandibular inclination also was the highest at 26.5° for the central incisors, decreased also to about 0° at the second premolars, and continued to decrease for the 2 molars. For the opposing tooth pairs, the interdental mesiodistal angulations always remained within 10° from one another, whereas the interdental faciolingual inclination increased from about 120° for the incisors to about 180° for the second premolars and the 2 molars. CONCLUSIONS: We obtained the average mesiodistal angulation and faciolingual inclination for each whole tooth measured from its long axis digitized on the cone-beam computed tomography volumetric images of 76 patients with near-normal occlusion. We found distinctive angulation and inclination relationships between the neighboring and opposing teeth. This information can be used in addition to the crown standards for positioning each whole tooth properly in the arches.

Gender differences in the effects of streptozotocin-induced diabetes on parasympathetic vasodilatation in the rat submandibular gland.

OBJECTIVES: Submandibular vasodilatory responses are impaired in male streptozotocin-diabetic rats. However, the effects of diabetes on submandibular vascular reactivity in female rats have not been examined. The purpose of this study was to determine whether there are gender differences in the effects of diabetes on parasympathetic vasodilatation in the rat submandibular gland. METHODS: Diabetes was induced using streptozotocin, and vascular responses (calculated as the % increase in submandibular vascular conductance) to parasympathetic stimulation (1-10 Hz) were measured using laser-Doppler flowmetry. To estimate the relative contributions of nitric oxide (NO), prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor (EDHF), vascular conductance was measured before and after inhibition of cyclooxygenase (COX) and NO synthase (NOS). RESULTS: Frequency-dependent increases in blood flow were observed in both male and female rats, but the contribution of EDHF was greater in females than in males. Further, PGI2 appeared to play a role only in males. Vasodilatory responses were diminished in all diabetic animals, and when compared with their respective controls the degree of impairment was similar in males and females. However, in diabetic males inhibition of COX and NOS had little or no effect, whereas inhibition of NO, but not COX, resulted in a further significant decrease in vascular responses in diabetic females. CONCLUSIONS: Parasympathetic vasodilatation in the rat submandibular gland is diminished equally in diabetic males and females. However, in males diabetes predominantly impairs PGI2- and NO-dependent vasodilatation, whereas in females the contribution of EDHF-mediated pathways are affected and NO-dependent vasodilatation is preferentially maintained.