1.
ACS Med Chem Lett
; 5(4): 428-33, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900853
RESUMO
3-Amido-3-aryl-piperidines were discovered as a novel structural class of GlyT1 inhibitors. The structure-activity relationship, which was developed, led to the identification of highly potent compounds exhibiting excellent selectivity against the GlyT2 isoform, drug-like properties, and in vivo activity after oral administration.