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1.
Laryngoscope ; 130(12): 2891-2895, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32031695

RESUMO

OBJECTIVES: There are no hearing protection regulations in place for passengers using public transport, such as the London Underground. In light of this, we sought to examine sound pressure levels experienced by regular users of the London Underground. METHODS: Sound pressure levels (A-weighted decibels: dBA) were taken on moving London Underground carriages between Euston and South Wimbledon on the Northern Line, and between Euston and Vauxhall on the Victoria Line, during 2006 and 2018. In addition, carriage sound pressure levels travelling within Zone 1 of the London Underground were tested in 2019. Three experimental and three technical repeats were undertaken using a hand-held calibrated multi-function sound level meter. RESULTS: Passengers are routinely and consistently subjected to sound pressure levels exceeding 80 dBA, with levels sometimes reaching over 100 dBA. CONCLUSION: This study is unique within the literature, with no published studies outlining exposure levels for London Underground passengers. It provides evidence of elevated noise exposure to passengers, consistently along large stretches of the London Underground, over a prolonged study period (2006-2019). KEY WORDS: Sensorineural hearing losssound pressureexposureLondonundergroundtube. LEVEL OF EVIDENCE: N/A Laryngoscope, 2020.


Assuntos
Perda Auditiva Provocada por Ruído/epidemiologia , Ruído dos Transportes/efeitos adversos , Exposição Ambiental , Monitoramento Ambiental , Humanos , Londres/epidemiologia
2.
BMJ Case Rep ; 12(11)2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31772133

RESUMO

Nasal fracture accounts for over 50% of facial fractures and is a frequent presentation to ear, nose and throat emergency clinics. Optimal management of nasal injuries with deformity is by manipulation under anaesthetic and should be offered when appropriate. A healthy 27-year-old woman presented with a lateral nasal wall mass with purulent discharge 1 month following manipulation. CT imaging revealed a mass arising from fragments of the nasal bone, consistent with an abscess. Bone fragments and purulent material were initially debrided, with a subsequent formal excision of a persistent granuloma performed with an excellent cosmetic outcome. This appears to be the first description of a granuloma resulting from a closed reduction-manipulation of a nasal fracture.


Assuntos
Redução Fechada/efeitos adversos , Ossos Faciais/microbiologia , Osso Nasal/microbiologia , Fraturas Cranianas/complicações , Abscesso/diagnóstico por imagem , Abscesso/patologia , Abscesso/cirurgia , Adulto , Desbridamento/métodos , Diagnóstico Diferencial , Ossos Faciais/patologia , Traumatismos Faciais/complicações , Traumatismos Faciais/patologia , Traumatismos Faciais/cirurgia , Feminino , Granuloma/etiologia , Granuloma/patologia , Granuloma/cirurgia , Humanos , Osso Nasal/patologia , Cavidade Nasal/diagnóstico por imagem , Cavidade Nasal/patologia , Fraturas Cranianas/microbiologia , Fraturas Cranianas/cirurgia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
3.
J Glob Antimicrob Resist ; 8: 186-191, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-28213334

RESUMO

Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. Bacterial biofilms are a significant problem in clinical settings owing to their increased tolerance towards conventionally prescribed antibiotics and their propensity for selection of further antibacterial resistance. There is therefore a pressing need for the development of alternative therapeutic strategies that can improve antibiotic efficacy towards biofilms. ROS has been successful in treating chronic wounds and in clearing multidrug-resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA), and carbapenemase-producing isolates from wounds and vascular line sites. There is significant antifungal activity of ROS against planktonic and biofilm forms. Nebulised ROS has been evaluated in limited subjects to assess reductions in bioburden in chronically colonised respiratory tracts. The antibiofilm activity of ROS could have great implications for the treatment of a variety of persistent respiratory conditions. Use of ROS on internal prosthetic devices shows promise. A variety of novel delivery mechanisms are being developed to apply ROS activity to different anatomical sites.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Bactérias/efeitos dos fármacos , Infecções Bacterianas/tratamento farmacológico , Biofilmes/efeitos dos fármacos , Espécies Reativas de Oxigênio/uso terapêutico , Infecção dos Ferimentos/tratamento farmacológico , Administração Tópica , Animais , Avaliação Pré-Clínica de Medicamentos , Fungos/efeitos dos fármacos , Humanos
4.
Auris Nasus Larynx ; 43(6): 595-601, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26992272

RESUMO

Infantile middle ear capillary haemangiomas (MECH) are a rare entity with only five reported cases in the literature. At present there is no consensus regarding the management of such lesions. Extra-cutaneous haemangiomas have been successfully managed with oral propranolol but not yet reported in MECH. We present a further case and appraise the management options. At present oral propranolol has not been used in the treatment of MECH. The literature suggests that infantile MECH have a higher propensity to spontaneously involute and a greater likelihood of response to propranolol. Surgical excision is the best option in older children and adults.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Neoplasias da Orelha/terapia , Orelha Média/cirurgia , Hemangioma Capilar/terapia , Procedimentos Cirúrgicos Otológicos , Propranolol/uso terapêutico , Criança , Neoplasias da Orelha/diagnóstico por imagem , Neoplasias da Orelha/patologia , Orelha Média/diagnóstico por imagem , Orelha Média/patologia , Hemangioma Capilar/diagnóstico por imagem , Hemangioma Capilar/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Tomografia Computadorizada por Raios X , Conduta Expectante
6.
Eur Arch Otorhinolaryngol ; 272(6): 1371-6, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24532083

RESUMO

Bone-anchored hearing aids (BAHAs) are based on the principle of osseointegration, which is fundamental to implant stability and survival. Previous exposure to ionising radiation may compromise this, as evidenced in relation to dental and craniofacial implants. There is a dearth of data, however, regarding BAHA implant systems in patients with previously irradiated implant sites. We sought, therefore, to investigate implant stability and survival in such patients. Patients were identified retrospectively from our electronic BAHA database. Hospital records were reviewed for demographics; operative technique; complications; and details regarding previous irradiation. Implant stability was assessed by resonance frequency analysis (RFA), generating a numerical value-implant stability quotient (ISQ). Extrapolating from dental studies, successfully loaded implants typically have ISQs of ≥60. Readings were, therefore, interpreted with respect to this. Seven patients were identified for inclusion. Mean time between irradiation and implant insertion was 33 months (range 16-72 months), and mean time from implant insertion to RFA measurement was 41 months (range 3-96 months). Operatively, all patients underwent single-stage procedures under local anaesthesia. One patient suffered a Holger's grade 2 skin reaction, while two suffered significant skin flap failure, requiring revision procedures. The implant survival rate was 100 %. All ISQ values were >60, with a mean of 66.9 (95 % confidence interval 63.1-70.6). Our data support sufficient osseointegration of BAHA implant systems in post-irradiated patients, but highlight issues with wound healing. Contemporary soft tissue preservation operative techniques will likely overcome this, facilitating safe and efficacious BAHA insertion in this ever-increasing group of patients.


Assuntos
Interface Osso-Implante , Auxiliares de Audição , Osseointegração/efeitos da radiação , Falha de Prótese/efeitos da radiação , Radioterapia/efeitos adversos , Interface Osso-Implante/fisiopatologia , Interface Osso-Implante/efeitos da radiação , Feminino , Neoplasias de Cabeça e Pescoço/radioterapia , Neoplasias de Cabeça e Pescoço/reabilitação , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Cicatrização/efeitos da radiação
7.
Artigo em Inglês | MEDLINE | ID: mdl-21694783

RESUMO

Cochlear implantation has become established worldwide as a safe and effective method of auditory rehabilitation of selected severely and profound deaf children and adults. Over 100,000 patients have received cochlear implants worldwide with the paediatric population proving to be the main beneficiaries. The Libyan cochlear implant programme was set up in 2004. Data relating to the patients who received cochlear implantation at Tripoli Medical Centre between October 2007 and February 2010 were analysed. Implant operations were performed on 37 patients. All patients received Med-El SONATA(TI) (100) devices. Thirty-four (91.9%) of these patients were children, whilst three (8.1%) were adults. Combined, congenital hearing loss (56.8%) and perinatal/neonatal (29.7%) were the two main aetiological factors in children. Seventeen patients (45.9%) had a positive family history of deafness. Sixteen patients (43.2%) were born to blood-related parents. The overall rate of minor and major complications was 16.2%, which is comparable to previous studies.

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